A5085264458- Gene expression and cancer classification
- Forensic and Genetic Research
- Genetic Associations and Epidemiology
- Genomics and Phylogenetic Studies
- Morphological variations and asymmetry
- dental development and anomalies
- Forensic Anthropology and Bioarchaeology Studies
- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
- Algorithms and Data Compression
- Biometric Identification and Security
- Dental Radiography and Imaging
- Genetic and phenotypic traits in livestock
- Face recognition and analysis
- Congenital limb and hand anomalies
- Linguistics and Cultural Studies
- melanin and skin pigmentation
- Face and Expression Recognition
- Molecular Biology Techniques and Applications
- Genetic diversity and population structure
- Bayesian Methods and Mixture Models
- Identification and Quantification in Food
- Metabolomics and Mass Spectrometry Studies
- Genomic variations and chromosomal abnormalities
- Oropharyngeal Anatomy and Pathologies
Indiana University – Purdue University Indianapolis
2019-2025
University of Pittsburgh
2024-2025
Indiana University Indianapolis
2023-2025
University of Indianapolis
2019-2023
Abstract Large-scale GWAS studies have uncovered hundreds of genomic loci linked to facial and brain shape variation, but only tens associated with cranial vault shape, a largely overlooked aspect the craniofacial complex. Surrounding neocortex, plays central role during development understanding its genetics are pivotal for conditions. Experimental biology prior genetic generated wealth knowledge that presents opportunities aid further discovery efforts. Here, we use conditional FDR method...
ABSTRACT Automatic dense 3D surface registration is a powerful technique for comprehensive shape analysis that has found successful application in human craniofacial morphology research, particularly within the mandibular and cranial vault regions. However, notable gap exists when exploring frontal aspect of skull, largely due to intricate unique nature its anatomy. To better examine this region, study introduces simplified single-surface bone mask comprising 9,999 quasi-landmarks, which can...
Automatic dense 3D surface registration is a powerful technique for comprehensive shape analysis that has found successful application in human craniofacial morphology research, particularly within the mandibular and cranial vault regions. However, notable gap exists when exploring frontal aspect of skull, largely due to intricate unique nature its anatomy. To better examine this region, study introduces simplified single-surface bone mask comprising 6707 quasi-landmarks, which can aid...
Abstract Estimates of individual-level genomic ancestry are routinely used in human genetics, and related fields. The analysis population structure can yield insights terms modern ancient populations, allowing us to address questions regarding admixture, the numbers identities parental source populations. Unrecognized is also an important confounder correct for genome-wide association studies. However, it remains challenging work with heterogeneous datasets from multiple studies collected by...
Facial landmark placement is a key step in many biomedical and biometrics applications. This paper presents computational method that efficiently performs automatic 3D facial based on training images containing manually placed anthropological landmarks. After face registration by an iterative closest point (ICP) technique, visual analytics approach taken to generate local geometric patterns for individual points. These individualized are derived interactively user's initial pattern...
Abstract Analysis of population structure and genomic ancestry remains an important topic in human genetics bioinformatics. Commonly used methods require high-quality genotype data to ensure accurate inference. However, practice, laboratory artifacts outliers are often present the data. Moreover, existing typically affected by presence related individuals dataset. In this work, we propose a novel hybrid method, called SAE-IBS, which combines strengths traditional matrix decomposition-based...
Facial ancestry can be described as variation that exists in facial features are shared amongst members of a population due to environmental and genetic effects. Even within Europe, faces vary among subregions may lead confounding association studies if unaccounted for. Genetic use principal components (PCs) describe circumvent this issue. Yet the phenotypic effect these PCs on face has yet described, phenotype-based alternatives compared. In anthropological studies, consensus utilized they...
Abstract Background Processing raw genomic data for downstream applications such as imputation, association studies, and modeling requires numerous third-party bioinformatics software tools. It is highly time-consuming resource-intensive with computational demands storage limitations that pose significant challenges increase cost. The use of tools independent one another, in a disjointed stepwise fashion, increases the difficulty sets forth higher error rates because fragmented job...
Abstract The cranial vault – the portion of skull surrounding brain and cerebellum is highly variable, clinically relevant, heritable, yet its genetic architecture remains poorly understood. Here, we conducted a joint multi-ancestry admixed multivariate GWAS on 3D shape extracted from magnetic resonance images 6,772 children ABCD study cohort, identifying 30 genome-wide significant loci replicating 20 these signals in 16,947 additional individuals UK Biobank. This was enriched for components...
Abstract The capability to infer biogeographic ancestry with curated panels of informative markers (AIMs) is a critical component DNA intelligence. There are many AIM that resolve population differentiation at continental level. Of late, several studies have directed marker discovery the Middle East because difficulties for this region amongst populations in Eurasia. process has remained largely unchanged, except most recent additions whole-genome sequence (WGS) data repositories which now...
Torus Palatinus (TP) is a common trait with an unclear aetiology. Although prior studies suggest hereditary component, the genetic factors that influence TP risk remain unknown. The purpose of this study to identify variants associated TP.
Abstract Background Analysis of population structure and genomic ancestry remains an important topic in human genetics bioinformatics. Commonly used methods require high-quality genotype data to ensure accurate inference. However, practice, laboratory artifacts outliers are often present the data. Moreover, existing typically affected by presence related individuals dataset. Results In this work, we propose a novel hybrid method, called SAE-IBS, which combines strengths traditional matrix...
Abstract Background Processing raw genomic data for downstream applications such as imputation, association studies, and modeling requires numerous third-party bioinformatics software tools. It is highly time-consuming resource-intensive with computational demands storage limitations that pose significant challenges increase cost. The use of tools independent one another, in a disjointed stepwise fashion, increases the difficulty sets forth higher error rates because fragmented job...