A5041524260- dental development and anomalies
- Molecular Biology Techniques and Applications
- Gene expression and cancer classification
- Craniofacial Disorders and Treatments
- Morphological variations and asymmetry
- Forensic and Genetic Research
- melanin and skin pigmentation
- Cleft Lip and Palate Research
- Skin Protection and Aging
- Genetic Associations and Epidemiology
- Race, Genetics, and Society
- Identification and Quantification in Food
- Traditional Chinese Medicine Studies
- Biblical Studies and Interpretation
- Global Educational Reforms and Inequalities
- Hair Growth and Disorders
- Nutrition, Genetics, and Disease
- Retinoids in leukemia and cellular processes
- Education and Communication Studies
- E-Learning and Knowledge Management
- Hong Kong and Taiwan Politics
- Bioinformatics and Genomic Networks
- Genetic diversity and population structure
- Impact of Technology on Adolescents
- Genomic variations and chromosomal abnormalities
University of Indianapolis
2019-2023
Indiana University – Purdue University Indianapolis
2019-2023
Indiana University Indianapolis
2023
The analysis of contemporary genomic data typically operates on one-dimensional phenotypic measurements (e.g. standing height). Here we report a data-driven, family-informed strategy to facial phenotyping that searches for biologically relevant traits and reduces multivariate 3D shape variability into amendable univariate measurements, while preserving its structurally complex nature. We performed biometric identification siblings in sample 424 children, defining 1,048 sib-shared traits....
Facial morphology is highly variable, both within and among human populations, a sizable portion of this variation attributable to genetics. Previous genome scans have revealed more than 100 genetic loci associated with different aspects normal-range facial variation. Most these been detected in Europeans, few studies focusing on other ancestral groups. Consequently, the degree which traits share common basis across diverse sets humans remains largely unknown. We therefore investigated an...
Unaffected relatives of individuals with non-syndromic cleft lip or without palate (NSCL/P) show distinctive facial features. The presence this endophenotype is potentially an expression underlying genetic susceptibility to NSCL/P in the larger unselected population. To explore hypothesis, we first partitioned face into 63 partially overlapping regions representing global-to-local morphology and then defined endophenotypic traits by contrasting 3D images from 264 unaffected parents versus...
Genome imputation, admixture resolution and genome-wide association analyses are timely computationally intensive processes with many composite requisite steps. Analysis time increases further when building installing the run programs required for these analyses. For scientists that may not be as versed in programing language, but want to perform operations hands on, there is a lengthy learning curve utilize vast number of available In an effort streamline entire process easy-to-use steps...
Abstract Estimates of individual-level genomic ancestry are routinely used in human genetics, and related fields. The analysis population structure can yield insights terms modern ancient populations, allowing us to address questions regarding admixture, the numbers identities parental source populations. Unrecognized is also an important confounder correct for genome-wide association studies. However, it remains challenging work with heterogeneous datasets from multiple studies collected by...
Abstract Accurate inference of genomic ancestry is critically important in human genetics, epidemiology, and related fields. Geneticists today have access to multiple heterogeneous population-based datasets from studies collected under different protocols. Therefore, joint analyses these require robust consistent ancestry, where a common strategy yield an space generated by reference dataset. However, such sensitive batch artefacts introduced In this work, we propose novel genome-wide...
Abstract The human face is complex and multipartite, characterization of its genetic architecture remains intriguingly challenging. Applying GWAS to multivariate shape phenotypes, we identified 203 genomic regions associated with normal-range facial variation, 117 which are novel. enriched for both genes relevant craniofacial limb morphogenesis enhancer activity in cranial neural crest cells tissues. Genetic variants grouped by their contribution similar aspects variation show high...
Abstract The cranial vault – the portion of skull surrounding brain and cerebellum is highly variable, clinically relevant, heritable, yet its genetic architecture remains poorly understood. Here, we conducted a joint multi-ancestry admixed multivariate GWAS on 3D shape extracted from magnetic resonance images 6,772 children ABCD study cohort, identifying 30 genome-wide significant loci replicating 20 these signals in 16,947 additional individuals UK Biobank. This was enriched for components...
ABSTRACT Evidence from both model organisms and clinical genetics suggests close coordination between the developing brain face 1–8 , but it remains unknown whether this developmental link extends to genetic variation that drives normal-range diversity of shape. Here, we performed a multivariate genome-wide association study cortical surface morphology in 19,644 European-ancestry individuals identified 472 genomic loci influencing shape at multiple levels. We discovered substantial overlap...