A5072385531- Morphological variations and asymmetry
- Molecular Biology Techniques and Applications
- Genetic Associations and Epidemiology
- Gene expression and cancer classification
- Evolutionary Psychology and Human Behavior
- Epigenetics and DNA Methylation
- dental development and anomalies
- Craniofacial Disorders and Treatments
- melanin and skin pigmentation
- Genetic and phenotypic traits in livestock
- Forensic and Genetic Research
- Air Quality and Health Impacts
- Face recognition and analysis
- Cleft Lip and Palate Research
- Ocular Disorders and Treatments
- Alcohol Consumption and Health Effects
- Bioinformatics and Genomic Networks
- Cannabis and Cannabinoid Research
- Substance Abuse Treatment and Outcomes
- Advanced MRI Techniques and Applications
- Genetic Syndromes and Imprinting
- Race, Genetics, and Society
- AI in cancer detection
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
RTI International
2022-2025
Research Triangle Park Foundation
2025
National Institute of Environmental Health Sciences
2021-2024
National Institutes of Health
2021-2024
Stanford University
2022
Pennsylvania State University
2017-2021
KU Leuven
2019
Clemson University
2016
Wildfowl & Wetlands Trust
2016
University College London
2015
Dense surface registration, commonly used in computer science, could aid the biological sciences accurate and comprehensive quantification of phenotypes. However, few toolboxes exist that are openly available, non-expert friendly, validated a way relevant to biologists. Here, we report customizable toolbox for reproducible high-throughput dense phenotyping 3D images, specifically geared towards use. Given target image, template is first oriented, repositioned, scaled during rigid...
BackgroundSmoking impacts DNA methylation, but data are lacking on smoking-related differential methylation by sex or dietary intake, recent smoking cessation (<1 year), persistence of from in utero exposure, and effects environmental tobacco smoke (ETS).MethodsWe meta-analysed up to 15,014 adults across 5 cohorts with measured blood using Illumina's EPIC array for current (2560 exposed), quit < 1 year (500 (286 ETS exposure (676 exposed). We also evaluated the interaction diet (fibre,...
Facial recognition from DNA refers to the identification or verification of unidentified biological material against facial images with known identity. One approach establish identity is predict face DNA, and subsequently match images. However, phenotyping human remains challenging. Here, another proof concept biometric authentication established by using multiple face-to-DNA classifiers, each classifying given faces a DNA-encoded aspect (sex, genomic background, individual genetic loci),...
Recent studies have called into question the idea that facial masculinity is a condition-dependent male ornament indicates immunocompetence in humans. We add to this growing body of research by calculating an objective measure masculinity/femininity using 3D images large sample (n = 1,233) people European ancestry. show positively correlated with adult height both males and females. However, scales growth similarly females, suggesting not exclusively ornament, as ornaments are typically more...
BACKGROUND: Pesticide exposure is associated with many long-term health outcomes; the potential underlying mechanisms are not well established for most associations.Epigenetic modifications, such as DNA methylation, may contribute.Individual pesticides be specific methylation patterns but no epigenome-wide association study (EWAS) has evaluated in relation to individual pesticides.OBJECTIVES: We conducted an EWAS of several pesticide active ingredients.METHODS: The Agricultural Lung Health...
Many factors influence human facial morphology, including genetics, age, nutrition, biomechanical forces, and endocrine factors. Moreover, features clearly differ between males females, these differences are driven primarily by the of sex hormones during growth development. Specific genetic variants known to circulating hormone levels in humans, which we hypothesize, turn, affect features. In this study, investigated effects testosterone-related on morphology. We tested 32 across 22...
Perfect bilateral symmetry is the optimal outcome of development traits in absence developmental perturbations. Any random perturbation this perfect symmetrical state called Fluctuating Asymmetry (FA). Many studies have been conducted on FA as an indicator Developmental Instability (DI) and its possible link with stress individual quality general attractiveness, health level masculinity or femininity humans. Most human facial asymmetry use 2D pictures a limited number landmarks. We developed...
Abstract Background Alcohol use disorder (AUD) has a profound public health impact. However, understanding of the molecular mechanisms underlying development and progression AUD remain limited. Here, we interrogate AUD-associated DNA methylation (DNAm) changes within across addiction-relevant brain regions: nucleus accumbens (NAc) dorsolateral prefrontal cortex (DLPFC). Methods Illumina HumanMethylation EPIC array data from 119 decedents European ancestry (61 cases, 58 controls) were...
As technology advances and collaborations grow, our ability to finely quantify explore morphological variation in 3D structures can enable important discoveries insights into clinical, evolutionary, genetic questions. However, it is critical understand the relative contribution of potential sources error under study. In this study, we isolated level facial images attributable four sources, using 3dMDface Vectra H1 camera systems. When two systems are used separately image human participants,...
The analysis of contemporary genomic data typically operates on one-dimensional phenotypic measurements (e.g. standing height). Here we report a data-driven, family-informed strategy to facial phenotyping that searches for biologically relevant traits and reduces multivariate 3D shape variability into amendable univariate measurements, while preserving its structurally complex nature. We performed biometric identification siblings in sample 424 children, defining 1,048 sib-shared traits....
Objectives: Orofacial clefting is one of the most prevalent craniofacial malformations. Previous research has demonstrated that unaffected relatives patients with non-syndromic cleft lip with/without palate (NSCL/P) show distinctive facial features, which can be an expression underlying NSCL/P susceptibility genes. These results support hypothesis genes involved in occurrence a also play role normal development. In this study, we investigated influence genetic variants associated on...
Facial morphology is highly variable, both within and among human populations, a sizable portion of this variation attributable to genetics. Previous genome scans have revealed more than 100 genetic loci associated with different aspects normal-range facial variation. Most these been detected in Europeans, few studies focusing on other ancestral groups. Consequently, the degree which traits share common basis across diverse sets humans remains largely unknown. We therefore investigated an...
Unaffected relatives of individuals with non-syndromic cleft lip or without palate (NSCL/P) show distinctive facial features. The presence this endophenotype is potentially an expression underlying genetic susceptibility to NSCL/P in the larger unselected population. To explore hypothesis, we first partitioned face into 63 partially overlapping regions representing global-to-local morphology and then defined endophenotypic traits by contrasting 3D images from 264 unaffected parents versus...
Medically unexplained symptoms (MUS) are not only common and distressing, but also typically poorly managed in general medical settings. Those suffering from these problems tend to incur significantly higher health costs than the population. There many effective treatments for different MUS; almost entirely based on cognitive-behavioural approaches. However, wide range of treatment protocols be ‘syndrome specific’. As such, they do generalise well terms training application, making them...
Homologous recombination (HR) is a template-driven repair pathway that mends DNA double-stranded breaks (DSBs), and thus helps to maintain genome stability. The RAD51 recombinase facilitates joint formation during HR, but accomplish this task, must be loaded onto the single-stranded DNA. DSS1, candidate gene for split hand/split foot syndrome, provides ability recognize RPA-coated ssDNA tumor suppressor BRCA2, which complexed with RAD51. Together BRCA2-DSS1 displace RPA load ssDNA. In...
Background: In low- and middle-income countries, burning biomass indoors for cooking or heating has been associated with poorer lung function. high-income wood, a form of biomass, is commonly used in rural areas increasing prevalence. However, these settings the potential impact chronic indoor woodsmoke exposure on pulmonary function little studied. Objective: We evaluated association residential wood case–control study asthma nested within U.S. cohort. Methods: Using sample weighted...
Many studies have suggested that developmental instability (DI) could lead to asymmetric development, otherwise known as fluctuating asymmetry (FA). Several attempts unravel the biological meaning of FA been made, yet main step in estimating is remove effects directional (DA), which defined average bilateral at population level. Here, we demonstrate a multivariate context conventional method DA correction does not adequately compensate for other dimensions asymmetry. This appears be due...
Abstract Estimates of individual-level genomic ancestry are routinely used in human genetics, and related fields. The analysis population structure can yield insights terms modern ancient populations, allowing us to address questions regarding admixture, the numbers identities parental source populations. Unrecognized is also an important confounder correct for genome-wide association studies. However, it remains challenging work with heterogeneous datasets from multiple studies collected by...