A5018419865- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Gold and Silver Nanoparticles Synthesis and Applications
- Plasmonic and Surface Plasmon Research
- SARS-CoV-2 detection and testing
- Advanced Biosensing Techniques and Applications
- SARS-CoV-2 and COVID-19 Research
- RNA Interference and Gene Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- Quantum Dots Synthesis And Properties
- Bacteriophages and microbial interactions
- Electrowetting and Microfluidic Technologies
- Spectroscopy Techniques in Biomedical and Chemical Research
- ATP Synthase and ATPases Research
- Nanopore and Nanochannel Transport Studies
- Surface Roughness and Optical Measurements
- Optical Coatings and Gratings
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Near-Field Optical Microscopy
- Microfluidic and Capillary Electrophoresis Applications
- Electron and X-Ray Spectroscopy Techniques
- Microfluidic and Bio-sensing Technologies
- Cancer, Stress, Anesthesia, and Immune Response
- Optical Polarization and Ellipsometry
Huazhong University of Science and Technology
2020-2024
Intel (United States)
2019
University of Illinois Urbana-Champaign
2016
University of California, Berkeley
2004-2007
University of California, San Francisco
2005
University of Toledo
2002
We present novel gold nanophotonic crescent moon structures with a sub-10 nm sharp edge, which can enhance local electromagnetic field at the edge area. The formation of unconventional structure is accomplished by using sacrificial nanosphere template and conventional thin film deposition method, allows an effective batch nanofabrication precise controls nanostructure shapes. Unique multiple scattering peaks are observed in single nanocrescent dark-field white light illumination. A 785...
Combining immune checkpoint blockade (ICB) therapy with photodynamic (PDT) holds great potential in treating immunologically "cold" tumors, but photo-generated reactive oxygen species (ROS) can inevitably damage co-administered ICB antibodies, hence hampering the therapeutic outcome. Here we create a ROS-responsive hydrogel to realize sustained co-delivery of photosensitizers and antibodies. During PDT, skeleton poly(deca-4,6-diynedioic acid) (PDDA) protects antibodies by scavenging harmful...
Abstract Developing plasmonic biosensors that are low‐cost, portable, and relatively simple to operate remains challenging. Herein, a novel metasurface plasmon‐etch immunosensor is described, namely nanozyme‐linked immunosorbent surface plasmon resonance biosensor, for the ultrasensitive specific detection of cancer biomarkers. Gold‐silver composite nano cup array chip artificial nanozyme‐labeled antibody used in two‐way sandwich analyte detection. Changes biosensor's absorption spectrum...
We report a tunable microdoublet lens capable of creating dual modes biconvex or meniscus lens. The consists liquid-filled and solid negative It can be tuned either by changing the shape into bi-convex filling media with different refractive index. micro-fabrication is based on photopolymer microdispensing elastomer micromolding methods. provide solution for minimizing optical aberrations maximizing tunability focal length field view controlling variable fixed curvatures.
Abstract Considering the improved detection of biological analytes for affinity analysis is highly desirable, a metasurface plasmon resonance (Meta‐SPR)‐based imaging system, incorporating localized SPR sensing platform with different microfluidic systems and employing simple bright‐field imaging, established in this study. This system enables low‐level analyte concentration analysis, ranging from 100 p m to n , real‐time removal nonspecific binding signals within same device field view....
Abstract A robust serological test is required to detect neutralizing antibodies (NAbs) against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). nanomaterial‐coupled metasurface plasmon resonance (MetaSPR) biosensor developed for rapid multiplexing quantitative tests of the half maximal inhibitory concentration (IC50) value SARS‐CoV‐2 NAbs in human sera. This applied a MetaSPR competitive or surrogate virus neutralization (MSPR VNT) used quantifying NAb‐mediated blockage...
Abstract Non‐invasive biosensors have attracted attention for their potential to obtain continuous, real‐time physiological information through measurements of biochemical markers, such as one the most important—glucose, in biological fluids. Although some optical sensing materials are used non‐invasive devices continuous glucose monitoring (CGM), surface or localized plasmon material seldom applied CGM owing modest sensitivity and bulk apparatus. Herein, a metasurface (MGMSPR) biosensor...
Abstract A fast and reliable method for the detection of molecular interactions in real‐time is necessary drug screening control infections or diseases. Therefore, this study aims to develop a high‐throughput portable nanoplasmonic platform. This done by integrating nanocup array‐enhanced surface plasmon resonance (NanoSPR) sensor with standard 96‐well plate simple eight‐pillar device, which can offer rapid label‐free interaction analysis highly sensitive binding kinetics screening. To...
African swine fever (ASF) is one of the most serious transnational diseases in world. The case fatality rate susceptible pigs up to 100%. Currently, no commercial vaccine available, so prevention and control ASF mainly relies on early diagnosis culling infected pigs. As virus continues evolve, develop, diversify, nucleic acid testing becomes less efficient. Here, we developed a method for rapid direct optical measurement (ASFV) antibody vitro. This one-step procedure requires nearly sample...
Based on numerical studies of apertured metallic nanocavity structures, we describe a new intra-particle plasmonic interaction pathway that couples the plasmon resonance modes aperture edge and cavity. In contrast to inter-particle coupling schemes require precisely arrayed nanoparticles, this scheme achieves tunability in wavelength using single standalone nanostructure. addition, when is made sharp, it functions dually as tip amplifies its near-field producing local filed enhancement...
Real-time in situ detection of active proteases is crucial for early-stage cancer screening and cell signaling pathway study; however, it difficult to achieve using fluorescence or radioactive probes at volumes below 1 nL. Here we demonstrated a hybrid optical probe by incorporating nanocrescent particle peptides with artificial tag molecules. We performed proof-of-concept study prostate specific antigen (PSA), one the most prominent markers, serine protease present patients' seminal fluid...
In this investigation, a polarization-based imaging system is developed and described that measures the two-dimensional effective backscattering Mueller matrix of sample in near real-time. As well known, can provide considerable information on makeup optical characteristics also directly describes how transforms an incident light beam. The ability to measure biological sample, therefore, composition as potential reveal significant structural normally would not be visible through standard...
A multispectral microscopy imaging system is developed for the single-particle scattering spectroscopy of many individual plasmonic nanostructures simultaneously. The dispenses with need mechanical scanning sample stage and thus enables high-speed plasmon resonance nanostructure arrays. darkfield intensity images nanoplasmonic structures at wavelengths are acquired a spectral resolution 2 nm in wavelength range from 500 to 800 nm, frame rate seconds/wavelength. processed afterwards every...
The authors observed strong fluorescence (FL) enhancement from CdSe quantum dots (QDs) partially encapsulated in a smooth Au film with subwavelength apertures. So far, the of QDs placed on metallic surfaces has been mostly quenched unless surface was roughened nanoscale. pocketed QD FL emitted through nanoaperture exhibited up to fivefold when compared those plain or glass surfaces. depends strongly thickness and becomes maximized at 50nm. This study shows that dependence may be closely...
Public health concerns have been raised by numerous reports of severe acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2) and its variations infecting a range animals. Wildlife reservoirs may facilitate the evolution viral types capable causing human infection in future. Therefore, epidemiological monitoring animals close contact with humans is necessary. Yet, symptoms are not obvious most animals, which leads to short nucleic acid test‐detection period limits application this method...
Au nanoparticles have distinctive absorption spectra whose peak position or particle plasmon resonance wavelength is highly sensitive to molecule adsorption on their surfaces. Spherical are surface-modified by amino-functionalized self-assembly-monolayer and used as optical probes in the fluorescence-label-free spectroscopic detection of sub-nanomole oligonucleotides. Time-resolved studies immobilization hybridization oligonucleotides surface were carried out. By measuring shift colloidal...