A5101354563- Glycosylation and Glycoproteins Research
- vaccines and immunoinformatics approaches
- RNA and protein synthesis mechanisms
- Biochemical and Molecular Research
- Viral Infections and Vectors
- Immune Response and Inflammation
- Machine Learning in Bioinformatics
- Virology and Viral Diseases
Ministry of Agriculture and Rural Affairs
2024
China Agricultural University
2024
Bats serve as reservoirs for numerous zoonotic viruses, yet they typically remain asymptomatic owing to their unique immune system. Of particular significance is the MHC-I in bats, which plays crucial role anti-viral response and exhibits polymorphic amino acid (AA) insertions. This study demonstrated that both 5AA 3AA insertions enhance thermal stability of bat complex enrich diversity bound peptides terms quantity length distribution, by stabilizing 3
Abstract Predicting MHC-II restricted epitopes across species used to be challenging, but Alphafold (AF) may provide a structure-based pan-prediction solution. In this study, we established the new tool AF-pred with clear standard for quantitative prediction results. Compared sequence-based tools heavily trained human ligandome, does not show advantage in predicting binding patterns of HLA-II has far better performance other animals’ MHC-II. Using recently resolved bat structures, analyzed...