A5029764507- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- CAR-T cell therapy research
Vita-Salute San Raffaele University
2023-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2024-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2024-2025
CD4+ T cells play a critical role in supporting antiviral humoral and cellular immune responses. Although these responses often coexist, one can sometimes dominate at the expense of other. For instance, lymphocytic choriomeningitis virus (LCMV) induces strong response but generates suboptimal neutralizing antibody (nAb) response, hindering viral clearance enabling persistent infection. Recent findings indicate that this skewed preference toward immunity is determined already during...
Abstract CD4 + T cells play a critical role in antiviral humoral and cellular immune responses. We have previously reported that subcutaneous lymphocytic choriomeningitis virus (s.c. LCMV) infection is characterized by stark compartmentalization of cells, leading to strong H 1 cell polarization but virtually absent follicular helper (T FH ) key drivers immunity. Here, we investigate the mechanisms responsible for this impaired differentiation. show T-bet induced LCMV encompass subset...
Abstract T DC are hematopoietic cells that combine dendritic cell (DC) and conventional T‐cell markers functional properties. They were identified in secondary lymphoid organs (SLOs) of naïve mice as expressing CD11c, major histocompatibility molecules (MHC)‐II, the receptor (TCR). Despite thorough characterization, a physiological role for remains to be determined. Unfortunately, using CD11c marker has caveat its upregulation on different cells, including upon activation. Here, we took...
Abstract T DC are hematopoietic cells that combine dendritic cell (DC) and conventional markers functional properties. They were identified in secondary lymphoid organs (SLOs) of naïve mice as expressing CD11c, major histocompatibility molecule (MHC)-II, the receptor (TCR) β chain. Despite thorough characterization to their potential properties, a physiological role for remains be determined. Unfortunately, using CD11c marker has caveat its upregulation on different cells, including upon...
Abstract Although humoral and cellular immunity upon viral infections usually co-exist, sometimes one of the two responses emerges as dominant is responsible for most antiviral activity. For example, vesicular stomatitis virus (VSV) infection induces early potent neutralizing antibody (nAb) responses, whereas lymphocytic choriomeningitis (LCMV) strong but weak nAb responses. Recent work from our laboratory has shown that unbalance observed also at level CD4 T cells with subcutaneous VSV...