A5015673052- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Dietary Effects on Health
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Pelvic and Acetabular Injuries
- Spinal Fractures and Fixation Techniques
- Circadian rhythm and melatonin
- Mitochondrial Function and Pathology
- Immune cells in cancer
- Gut microbiota and health
- Diet, Metabolism, and Disease
- Cytokine Signaling Pathways and Interactions
- Osteomyelitis and Bone Disorders Research
- PI3K/AKT/mTOR signaling in cancer
- NF-κB Signaling Pathways
- CCD and CMOS Imaging Sensors
- Embedded Systems and FPGA Design
- Advanced Drug Delivery Systems
- Heat shock proteins research
- Drug Solubulity and Delivery Systems
- Endoplasmic Reticulum Stress and Disease
- ATP Synthase and ATPases Research
- S100 Proteins and Annexins
Minghsin University of Science and Technology
2025
First Affiliated Hospital of Xiamen University
2022-2024
Shanghai Institute of Nutrition and Health
2020-2023
University of Chinese Academy of Sciences
2020-2023
Newcastle University
2020
Wenzhou Medical University
2020
Putian University
2017-2018
Southern Medical University
2018
Fujian Medical University
2018
Nanfang Hospital
2018
Numerous evidence indicates that inflammation in adipose tissue is the primary cause of systemic insulin resistance induced by obesity. Obesity-associated changes circulating LPS level and hypoxia/HIF-1α activation have been proposed to be involved boosting obesity-induced inflammation. However, there poor understanding what triggers In this study, we pinpoint lactate as a key trigger mediate resistance. Specific deletion Slc16a1 encodes MCT1, transporter tissues, robustly elevates blood...
Ovarian cancers are frequently not diagnosed until advanced stages, resulting in a high case fatality rate. Because of this, more tumor markers, addition to CA125, for detecting and monitoring ovarian cancer needed. During systematic search potential biomarkers cancer, we compared the protein profiles between interstitial fluid normal ovaries, rationalizing that abnormal levels proteins may be detected peripheral blood thus serve as easily accessible markers. Here, show stress-induced...
Background Activating the Stimulator of Interferon Genes (STING) adaptor incites antitumor immunity against immunogenic tumors in mice, prompting clinical trials to test STING activators. However, signaling tumor microenvironment (TME) during development Lewis lung carcinoma (LLC) suppresses promote growth. We hypothesized that local immune balance favoring suppression also attenuates responses following activation. The purpose this study was evaluate how activation impacts mice bearing LLC...
Estrogens and tamoxifen (an antiestrogen) exert their actions by activation of estrogen receptor (ER) through genomic non-genomic mechanisms are implicated in the development endometrial cancer. Previous reports have demonstrated that estradiol induce proliferation human cancer cells GPR30 (non-genomic ER) signaling pathway. Herein, we demonstrate phosphorylation focal adhesion kinase (FAK) is involved cell migration induced estradiol, G1 (a agonist) transmembrane ER (GPR30) lines with or...
Huntington disease (HD) is a degenerative disorder caused by expanded CAG repeats in exon 1 of the huntingtin gene (HTT). Patients with late-stage HD are known to have abnormal auditory processing, but peripheral functions patients yet be thoroughly assessed. In this study, 19 (aged 40-59 years) were assessed for hearing impairment using pure-tone audiometry and assessment brainstem responses (ABRs). PTA thresholds markedly elevated patients. Consistent this, ABR also detected two mouse...
Temperature sensitive Pluronic (Plu) and pH-sensitive polyacrylic acid (PAA) were successfully mixed in different ratios to form situ gelling formulations for colon cancer therapy. The major prepared as the liquid solid suppository dosage forms. Epirubicin (Epi) was chosen a model anticancer drug. In vitro characterization vivo pharmacokinetics therapeutic efficacy of Epi six Plu/PAA evaluated. Our data indicate that Plu 14%/PAA 0.75% both suppositories possess significant cytotoxicity,...
Abstract Statins, the first‐line medication for dyslipidemia, are linked to an increased risk of type 2 diabetes. But exactly how statins cause diabetes is yet unknown. In this study, a developed short‐term statin therapy on hyperlipidemia mice show that hepatic insulin resistance statin‐induced Statin raises expression progesterone and adiponectin receptor 9 (PAQR9) in liver, which inhibits signaling through degradation protein phosphatase, Mg 2+ /Mn dependent 1 (PPM1 α ) activate ERK...
During inflammation or tissue injury, pro-inflammatory mediators attract migratory monocytes to inflammatory sites and monocyte-to-macrophage differentiation occurs activate macrophages. We report here that PAQR11, a member of the progesterone AdipoQ receptor family, regulates in vitro vivo. Paqr11 gene was highly induced during differentiation. Knockdown deletion inhibited monocyte but had little effect on macrophage polarization. Mechanistically, PAQR11 promoted cell survival as apoptosis...
Background/Aims: The mechanistic target of rapamycin (mTOR) signaling pathway is essential for angiogenesis and embryonic development. DEP domain-containing mTOR-interacting protein (DEPTOR) an mTOR binding that functions to inhibit the In vitro experiments suggest DEPTOR crucial vascular endothelial cell (EC) activation angiogenic responses. However, knowledge effects on in vivo limited. This study aimed determine role tissue elucidate molecular mechanisms. Methods: Cre/loxP conditional...
The cycle of feeding and fasting is fundamental to life closely coordinated with changes metabolic programs. During extended starvation, ketogenesis coupled fatty acid oxidation in the liver supplies ketone bodies extrahepatic tissues as major form fuel. In this study, we demonstrated that PAQR9, a member progesterone adipoQ receptor family, has regulatory role on hepatic ketogenesis. We analyzed phenotype Paqr9-deleted mice. also used biochemical methods investigate interaction PAQR9 PPARα...
Time-restricted feeding (TRF) is an emerging dietary intervention that improves metabolic disorders such as obesity, insulin resistance and dyslipidemia. Inflammatory bowel disease (IBD) a chronic inflammatory disorder affecting the gastrointestinal tract, where nutrition plays important role in its pathogenesis. Although numerous strategies of nutritional have been reported, whether TRF can improve IBD has elusive. In this study, we investigated effect two cycles 7-day dextran sulfate...
Fat storage and mobilization in adipose tissue play a central role energy metabolism are directly linked to the development of obesity. Upon starvation, fat is mobilized from by lipolysis, process which triglycerides hydrolyzed free fatty acids be used as an source skeletal muscles other tissues. However, how lipolysis activated starvation not fully known. In this study, we demonstrate that PAQR11, member progesterone AdipoQ receptor family, regulates starvation-mediated lipolysis....
Protein quality control is crucial for maintaining cellular homeostasis and its dysfunction closely linked to human diseases. The post-translational protein machinery mainly composed of BCL-2-associated athanogene 6 (BAG6) responsible triage mislocalized membrane proteins (MLPs). However, it unknown how the BAG6-mediated degradation MLPs regulated. We report here that PAQR9, a member Progesterone AdipoQ receptor (PAQR) family, able modulate MLPs. Analysis with mass spectrometry identified...
The monocarboxylate transporter 1 (MCT1), encoded by gene Slc16a1, is a proton-coupled for lactate and other monocarboxylates. MCT1-mediated transport was recently found to regulate various biological functions. However, how MCT1 in the intestine modulate physiology pathophysiology of body unclear. In this study, we generated mouse model with specific deletion Slc16a1 intestinal epithelium (Slc16a1 IKO mice) investigated functions gut. When fed high-fat diet, male mice had improvement...
Dietary restriction has a profound effect in altering immune system and promoting metabolic health aging. However, how dietary impacts erythroid is largely unknown. We found that short-term caloric (CR) stimulates expression of KLF1, master regulator development, the spleen mouse, thus explored potential CR on erythropoiesis. analyzed effects intermittent continuous for different lengths time parameters peripheral blood profiles bone marrow C57BL/6 mice. next assessed types affect...