A5086749128- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- vaccines and immunoinformatics approaches
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- COVID-19 and healthcare impacts
- RNA and protein synthesis mechanisms
- COVID-19 Impact on Reproduction
- RNA Interference and Gene Delivery
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Respiratory viral infections research
- Advanced biosensing and bioanalysis techniques
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Viral Infections and Immunology Research
- Extracellular vesicles in disease
- Diabetes Treatment and Management
- Animal Virus Infections Studies
- Long-Term Effects of COVID-19
- Hemoglobinopathies and Related Disorders
- Natural Antidiabetic Agents Studies
- Viral gastroenteritis research and epidemiology
- Inflammatory Biomarkers in Disease Prognosis
- Diet and metabolism studies
King Saud University
2021-2025
University of Bristol
2020-2022
University of Oxford
2020
Abstract As the global burden of SARS-CoV-2 infections escalates, so does evolution viral variants with increased transmissibility and pathology. In addition to this entrenched diversity, RNA viruses can also display genetic diversity within single infected hosts co-existing evolving differently in distinct cell types. The BriSΔ variant, originally identified as a subpopulation from isolate hCoV-19/England/02/2020, comprises spike an eight amino-acid deletion encompassing furin recognition...
Abstract Background ChAdOx1 nCoV-19 is a recombinant adenovirus vaccine against SARS-CoV-2 that has passed phase III clinical trials and now in use across the globe. Although replication-defective normal cells, 28 kbp of genes delivered to cell nucleus alongside S glycoprotein gene. Methods We used direct RNA sequencing analyse transcript expression from genome human MRC-5 A549 lines are non-permissive for vector replication permissive line, HEK293. In addition, we quantitative proteomics...
For centuries, plants and their components have been harnessed for therapeutic purposes, with Ammi visnaga L. (Khella) being no exception to this rich tradition. While existing studies shed light on the cytotoxic antimicrobial properties of seed extracts, there remains a noticeable gap in research about antimicrobial, antioxidant, anticancer potential root extracts. This study seeks address by systematically examining methanol extracts derived from roots A. comparing effects those...
The SARS-CoV-2 virus has a complex transcriptome characterised by multiple, nested subgenomic RNAsused to express structural and accessory proteins. Long-read sequencing technologies such as nanopore direct RNA can recover full-length transcripts, greatly simplifying the assembly of structurally RNAs. However, these techniques do not detect 5' cap, thus preventing reliable identification quantification full-length, coding transcript models. Here we used Nanopore ReCappable Sequencing...
BACKGROUND: Hyperuricemia is linked to an increased risk of various chronic diseases, but data on the prevalence and association hyperuricemia with liver function in Saudi Arabia are scarce. OBJECTIVES: Evaluate prevalence, association, measures population. DESIGN: Retrospective, cross-sectional analysis SETTING: Database large portion population PATIENTS AND METHODS: Laboratory data, age, gender studied subjects were collected from Al Borg Diagnostics. Subjects stratified, based their uric...
Background: Obesity and type 2 diabetes (T2D) pose global health problems that continue to rise. A chronic low-grade inflammation activation of the immune system are well established in both conditions. The presence these factors can predict disease development progression. Emerging evidence suggests platelet–high density lipoprotein ratio (PHR) is a potential inflammatory marker. purpose this study was investigate relationship between PHR T2D among obese patients. Methods: 203 patients with...
Rosmarinus officinalis L. has been widely used as a spice to enhance the shelf-life of food for centuries. While existing research in literature suggests that primary antibacterial component this plant is its essential oil (EO), there lack comparative studies employing both vitro and silico approaches evaluate antimicrobial, antioxidant, anticancer, antidiabetic properties R. leaf EO (ROLEO) methanolic extract (ROLME). The present study investigates bioactive components biological activities...
The coronavirus disease 2019 (COVID-19) vaccines have been developed to help prevent the spread of virus infections. COVID-19 vaccines, including Pfizer, Moderna, and AstraZeneca, undergone rigorous testing demonstrated both safety effectiveness. Extensive evidence supports their effectiveness in preventing severe illness, hospitalization, mortality associated with infection. administration can directly affect hematological biochemical parameters, reported cases showing an association...
Abstract Background: ChAdOx1 nCoV-19 is a recombinant adenovirus vaccine candidate against SARS-CoV-2. Although replication defective in normal cells, 28kbp of genes are delivered to the cell nucleus alongside SARS-CoV-2 S glycoprotein gene. Methods: We used direct RNA sequencing analyse transcript expression from genome human MRC-5 and A549 lines that non-permissive for vector permissive line, HEK293. In addition, we quantitative proteomics study over time proteome phosphoproteome MRC5...
Abstract Background The impact of COVID-19 infection on the blood system remains to be investigated, especially with those encountering hematological malignancies. It was found that a high proportion cancer patients are at an elevated risk infection. Leukemic often suppressed and immunocompromised, which would pathology following Therefore, this research aims bring valuable insight into mechanism by influences biochemical parameters acute leukemia. Methods This retrospective investigation...
Abstract Background The current study is a retrospective designed to evaluate changes in complete blood count and coagulation parameters adult coronavirus disease 2019 (COVID-19) patients at prominent Saudi tertiary center predict severity mortality. Methods cohort consisted of 74 800 divided into four groups based on COVID-19 test the patient’s sex: 35 985 female negative group, 23 278 male 8846 positive group 6691 group. Results Patients with demonstrated decreased white cell counts...
Background: Obesity is a growing global health concern, often accompanied by dyslipidemia, contributing to cardiovascular risk. Understanding the patterns of dyslipidemia in different glycemic states crucial for targeted interventions. This study compares normoglycemic and prediabetic obesity improve clinical management strategies. Methods: The analyzed complete lipid profiles 138 subjects, comparing medians, prevalence, diagnostic performance, risk assessment each parameter across 54...
Glucose-6-phosphate dehydrogenase (G6PD) insufficiency is a common enzymatic defect worldwide; it affects over 400 million people and associated with various disorders. Recent research suggests that G6PD-deficient cells are susceptible to infection by human coronaviruses, as the G6PD enzyme involved in metabolism of oxidative stress, which may enhance COVID-19 mortality. This retrospective study aimed examine effect on patients deficiency comparing laboratory parameters alone, those both...
Abstract SARS-CoV-2 has been proposed to encode ORF10 as the 3’ terminal gene in viral genome. However, potential role and even existence of a functional product subject debate. There are significant structural features genomic RNA that could, by themselves, explain retention nucleotide sequences without need for protein product. To explore this question further we made two recombinant viruses, firstly control virus (WT) based on genome sequence original Wuhan isolate with inclusion early...
The global COVID-19 pandemic has strained healthcare systems around the globe, necessitating extensive research into variables that affect patient outcomes. This study examines relationships between key haematology parameters, duration of hospital stay (LOS), and mortality rates in cases paediatric patients. Researchers analyse independent (COVID-19 status, age, sex) dependent (mortality, LOS, coagulation WBC count, RBC parameters) using multivariate regression models. Although R-square...
Abstract As the global burden of SARS-CoV-2 infections escalates, so does evolution viral variants which is particular concern due to their potential for increased transmissibility and pathology. In addition this entrenched variant diversity in circulation, RNA viruses can also display genetic within single infected hosts with co-existing evolving differently distinct cell types. The BriSΔ variant, originally identified as a subpopulation by passaging isolate hCoV-19/England/02/2020,...
Abstract The SARS-CoV-2 virus has a complex transcriptome characterised by multiple, nested sub genomic RNAs used to express structural and accessory proteins. Long-read sequencing technologies such as nanopore direct RNA can recover full-length transcripts, greatly simplifying the assembly of structurally RNAs. However, these techniques do not detect 5′ cap, thus preventing reliable identification quantification full-length, coding transcript models. Here we Nanopore ReCappable Sequencing...