A5065178979- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- HIV Research and Treatment
- Immune cells in cancer
- CAR-T cell therapy research
- Single-cell and spatial transcriptomics
- Phagocytosis and Immune Regulation
- interferon and immune responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Animal Disease Management and Epidemiology
- Herpesvirus Infections and Treatments
- Cancer Immunotherapy and Biomarkers
Servier (France)
2024
Université Paris Sciences et Lettres
2021-2023
Inserm
2017-2023
Institut Curie
2021-2023
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2017-2019
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2017-2019
Université Paris-Sud
2017-2018
Infectious Disease Models and Innovative Therapies
2017-2018
Abstract In inflamed tissues, monocytes differentiate into macrophages (mo-Macs) or dendritic cells (mo-DCs). chronic nonresolving inflammation, mo-DCs are major drivers of pathogenic events. Manipulating monocyte differentiation would therefore be an attractive therapeutic strategy. However, how the balance mo-DC versus mo-Mac fate commitment is regulated not clear. present study, we show that transcriptional repressors ETV3 and ETV6 control human mo-DCs. inhibit interferon (IFN)-stimulated...
Macrophages play a central role in tissue homeostasis and host defense. However, the properties of human macrophages non-diseased tissues remain poorly understood. Here, we characterized tonsil identified three subsets with distinct phenotype, transcriptome, life cycle, function. CD36hi were related to monocytes, while CD36lo showed features embryonic origin CD36int had mixed profile. scRNA-seq on non-human primate tonsils that monocyte recruitment did not pre-exist an immune challenge....
Dendritic cells (DC), which are involved in orchestrating early immune responses against pathogens, dysregulated their function by HIV infection. This dysregulation likely contributes to tip the balance toward viral persistence. Different DC subpopulations, including classical (cDCs) and plasmacytoid (pDCs) dendritic cells, subjected concomitant inflammatory immunoregulatory events during infection, hampers precise characterization of regulation through approaches. Here, we carried out mass...
Improving the selectivity and effectiveness of drugs represents a crucial issue for future therapeutic developments in immuno-oncology. Traditional bulk transcriptomics faces limitations this context early phase target discovery as resulting gene expression levels represent average measure from multiple cell populations. Alternatively, single RNA sequencing can dive into unique populations transcriptome, facilitating identification specific targets. Here, we generated Tumor-Infiltrating...
CD32a has been proposed as a specific marker of latently HIV-infected CD4+ T cells. However, was recently found to be expressed on cells healthy donors, leading controversy the relevance this in HIV persistence. Here, we used mass cytometry characterize landscape and variation abundance CD32a+ during infection. To end, analyzed primary infection before after effective combination antiretroviral therapy (cART) donors. We that include heterogeneous subsets are differentially affected by Our...
Abstract Improving the selectivity and effectiveness of drugs represents a crucial issue for future therapeutic developments in immuno-oncology. Traditional bulk transcriptomics faces limitations this context early phase target discovery as resulting gene expression levels represent average measure from multiple cell populations. Alternatively, single RNA sequencing can dive into unique populations transcriptome, facilitating identification specific targets. Here, we generated...