A5000017121- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Nuclear Receptors and Signaling
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Prion Diseases and Protein Misfolding
- Stress Responses and Cortisol
- Ubiquitin and proteasome pathways
- Caveolin-1 and cellular processes
- Computational Drug Discovery Methods
- Estrogen and related hormone effects
- Neurological disorders and treatments
- Intensive Care Unit Cognitive Disorders
- Wnt/β-catenin signaling in development and cancer
- Nicotinic Acetylcholine Receptors Study
- Mosquito-borne diseases and control
- Biochemical Analysis and Sensing Techniques
- Virology and Viral Diseases
- Anesthesia and Sedative Agents
- Venomous Animal Envenomation and Studies
- Tryptophan and brain disorders
- Anesthesia and Neurotoxicity Research
AC Camargo Hospital
2023
Universidade Federal de Minas Gerais
2014-2022
University of Ottawa
2019-2020
uOttawa Brain and Mind Research Institute
2020
MIND Research Institute
2019
Ottawa University
2019
University of Vermont
2019
The prevalence, presentation, and progression of Alzheimer's disease (AD) differ between men women, although β-amyloid (Aβ) deposition is a pathological hallmark AD in both sexes. Aβ-induced activation the neuronal glutamate receptor mGluR5 linked to progression. However, we found that exhibits distinct sex-dependent profiles. Specifically, isolated from male mouse cortical hippocampal tissues bound with high affinity Aβ oligomers, whereas female mice exhibited no such affinity. This...
Repressor element 1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a repressor and its expression regulated by the Wnt pathway through β-catenin. Metabotropic glutamate receptor 5 (mGluR5) signaling plays key role in controlling neuronal gene expression. Interestingly, REST/NRSF nuclear translocation signaling, as well mGluR5 are altered presence of mutant huntingtin. It remains unclear whether can modulate under physiological conditions this modulation...
Huntington's Disease (HD) is an autosomal-dominant neurodegenerative disorder, characterized by involuntary body movements, cognitive impairment, and psychiatric disorder. The metabotropic glutamate receptor 5 (mGluR5) plays important role in HD we have recently demonstrated that mGluR5-positive allosteric modulators (PAMs) can ameliorate pathology the phenotypic signs of a mouse model HD. In this study, investigated molecular mechanisms involved mGluR5 PAMs effect on memory. Our results...
Huntington’s disease (HD) is a neurodegenerative autosomal dominant disorder, characterized by symptoms of involuntary movement the body, loss cognitive function, psychiatric leading inevitably to death. It has been previously described that higher levels brain expression Ca v 1 channels are involved in major disorders, such as Alzheimer’s and Parkinson’s disease. Our results demonstrate bacterial artificial chromosome (BAC)-mediated transgenic mouse model (BACHD mice) at age 3 12 months...
Obesity represents a global health problem and is characterized by metabolic dysfunctions low-grade chronic inflammatory state, which can increase the risk of comorbidities, such as atherosclerosis, diabetes insulin resistance. Here we tested hypothesis that genetic deletion metabotropic glutamate receptor 5 (mGluR5) may rescue features present in BACHD mice, mouse model Huntington's disease (HD) with an obese phenotype. For that, crossed mGluR5 knockout mice (mGluR5
Abstract Glutamate receptors, including mGluR5, are involved in learning and memory impairments triggered by aging neurological diseases. However, each condition involves distinct molecular mechanisms. It is still unclear whether the mGluR5 cell signaling pathways normal brain differ from those altered due to neurodegenerative disorders. Here, we employed wild type (WT), −/− , BACHD, which a mouse model of Huntington’s Disease (HD), /BACHD mice, at ages 2, 6 12 months, distinguish...
exposure to ZIKV leads decreased number of neurons in adult mice. Female mice exposed
ABSTRACT Sex is a key modifier of the prevalence and progression Alzheimer’s disease (AD). β- Amyloid (Aβ) deposition pathological hallmark AD aberrant activation metabotropic glutamate receptor 5 (mGluR5) by Aβ has been linked to progression. We find that mGluR5 exhibits distinct sex-dependent pharmacological profiles. Specifically, endogenous from male mouse cortex hippocampus binds with high-affinity oligomers whereas, female no affinity oligomers. The binding oligomer dependent on its...
The Vel blood group antigen is carried on the short extracellular segment of 78-amino-acid-long, type II transmembrane protein SMIM1 unknown function. Here, using biochemical analysis and flow cytometry cells expressing wild-type mutant alleles SMIM1, we demonstrate that dimerization promotes cell surface display epitope. We show mediated both by an Cys77-dependent, homomeric disulfide linkage via a GxxxG helix-helix interaction motif in domain. These results provide important context for...
Sex is an important modifier of Alzheimer’s disease (AD) prevalence and progression. Aβ oligomers engage metabotropic glutamate receptor 5 (mGluR5) to mediate pathological signaling in AD. We find here, that mGluR5 intrinsically different male versus female mouse neurons, as agonist oligomer treatments inactivate a GSK3β/ZBTB16/ATG14-regulated autophagy pathway via Ser9 phosphorylation GSK3β mGluR5-dependent mechanism male, but not female, primary neuronal cultures. These observed...
Abstract Obesity represents a serious global public health problem and is characterized by low-grade chronic inflammatory state, which can increase the risk of comorbidities, such as: atherosclerosis, diabetes insulin resistance. In this study, we investigated effects genetic deletion metabotropic glutamate receptor 5 (mGluR5) on modulation obesity features in BACHD mice, mouse model Huntington´s disease. For that, crossed mGluR5 knockout mice (mGluR5 −/− ) order to obtain following groups:...