A5027472206- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Parasites and Host Interactions
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Research on Leishmaniasis Studies
- Neuroscience and Neuropharmacology Research
- Immune Cell Function and Interaction
- Anesthesia and Neurotoxicity Research
- Phagocytosis and Immune Regulation
- Virology and Viral Diseases
- Antibiotic Resistance in Bacteria
- Galectins and Cancer Biology
- Bladder and Urothelial Cancer Treatments
- Toxin Mechanisms and Immunotoxins
- Biomarkers in Disease Mechanisms
- Mosquito-borne diseases and control
- Immune responses and vaccinations
- Helminth infection and control
- Inflammasome and immune disorders
- Brucella: diagnosis, epidemiology, treatment
- Atherosclerosis and Cardiovascular Diseases
- Iron Metabolism and Disorders
Universidade Federal de Minas Gerais
2015-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023-2024
Université de Tours
2023-2024
Biologie des Oiseaux et Aviculture
2024
Trinity College Dublin
2017
Infectiologie Animale et Santé Publique
2017
Abstract Bacillus Calmette-Guerin (BCG) is the only FDA approved first line therapy for patients with nonmuscle invasive bladder cancer. The purpose of this study to better understand role innate immune pathways involved in BCG immunotherapy against murine tumor. We characterized immunological profile induced by MB49 mouse urothelial carcinoma cell line. cells were not able activate an inflammatory response (TNF-α, IL-6, CXCL-10 or IFN-β) after stimulus different agonists infection, unlike...
ABSTRACT Brucella abortus is a Gram-negative bacterium that infects humans and cattle, causing chronic inflammatory disease known as brucellosis. A Th1-mediated immune response plays critical role in host control of this pathogen. Recent findings indicate contrasting roles for lipid mediators responses against infections. 5-Lipoxygenase (5-LO) an enzyme required the production leukotrienes lipoxins. To determine involvement 5-LO to B. infection, we intraperitoneally infected wild-type...
The helminth Schistosoma mansoni modulates the infected host's immune system to facilitate its own survival, by producing excretory/secretory molecules that interact with a variety of cell types including those system. Herein, we characterise S. adult male worm secretome and identify 111 proteins, 7 vaccine candidates several potential immunomodulatory activity. Amongst present in secretome, 17-19kDa protein analogous human cyclophilin A was identified. Given ability modulate regulating...
Abstract Guanylate binding proteins (GBPs) are important effector molecules of autonomous response induced by proinflammatory stimuli, mainly IFNs. The murine GBPs clustered in chromosome 3 (GBPchr3) contains the majority human homologous GBPs. Despite intense efforts, mycobacterial-promoted diseases still a major public health problem. However, combined importance GBPchr3 during mycobacterial infection has been overlooked. This study addresses influence host immunity against to elucidate...
Neutrophils can be beneficial or deleterious during tuberculosis (TB). Based on the expression of MHC-II and programmed death ligand 1 (PD-L1), we distinguished two functionally transcriptionally distinct neutrophil subsets in lungs mice infected with mycobacteria. Inflammatory [MHC-II
Cutaneous leishmaniasis (CL) caused by Leishmania (Viannia) braziliensis is associated with an inflammatory response. Granzyme (GzmB) and IL-1β play a key role in the pathology. Meglumine antimoniate (MA) first-choice drug for treatment of CL, but therapy failure observed up to 50% cases. The protein, rSm29 Schistosoma mansoni, down-modulates pro-inflammatory cytokine production. We evaluate if combination topical plus MA increases cure rate CL.
Schistosomiasis is a parasitic disease with more than 200 million people infected worldwide. The formation of granulomas around eggs trapped in the liver main cause morbidity. Therefore, aim this investigation was to characterize immunopathological response induced by recombinant (r) IPSE/alpha-1 egg protein mice. Herein, we have shown that splenocytes from mice immunized rIPSE/alpha-1 produced IFN-gamma, TNF-alpha, IL-4, IL-5 and IL-13 characterizing mixed Th1/Th2 type immune response....
The Toll-like and IL-1 family receptors play critical roles in innate adaptive immunity against intracellular pathogens. Although previous data demonstrated the importance of TLRs IL-1R signaling events for establishment an effective immune response to mycobacteria, possible function adaptor molecule IL-1R-associated kinase (IRAK)-4 this pathogen has not been addressed. In study, we determined role IRAK-4 pathways responsible controlling mycobacterial infections. This is important production...
Astrocytes have been implicated in a wide range of neurodegenerative diseases, with the literature indicating harmful or beneficial roles on case-by-case basis. On such conditions, these cells are capable secreting several inflammatory factors and also promote synapse elimination remodeling. These responses possible because they sense their surroundings via receptors, including metabotropic glutamate receptor (mGluR5). However, mGluR5 activation astrocytes under neuroinflammatory conditions...
TNF-α is essential for induction and maintenance of inflammatory responses its dysregulation associated with susceptibility to various pathogens that infect the central nervous system. Activation both microglia astrocytes leads production, which in turn triggers further activation these cells. Astrocytes have been implicated pathophysiology a wide range neurodegenerative diseases either harmful or protective roles, as cells are capable secreting several factors also promote synapse...
exposure to ZIKV leads decreased number of neurons in adult mice. Female mice exposed
Neuroinflammation, particularly astrocyte reactivity, are increasingly linked to schizophrenia (SCZ). Yet, the crosstalk between astrocytes and microglia in SCZ, especially under pro-inflammatory conditions, remains unclear. Here, we apply human induced pluripotent stem cells (hiPSCs) compare reactivity of from individuals with SCZ neurotypical controls, towards resolving how patient-derived affect microglial biology. TNF-ɑ stimulation astrocytes, relative control trigger an increase...
Abstract Neutrophils can be beneficial or deleterious during tuberculosis (TB). Based on the expression of MHC-II and programmed death ligand 1 (PD-L1), we distinguished two functionally transcriptionally distinct neutrophil subsets in lungs mice infected with mycobacteria. Inflammatory [MHC-II - , PD-L1 lo ] neutrophils produced inflammasome-dependent IL-1β response to virulent mycobacteria “accelerated” inflammation, which was highly exacerbated IFN-γR -/- mice. Regulatory + hi “brake”...
Abstract Neutrophils can be beneficial or deleterious during tuberculosis (TB). Based on the expression of MHC-II and programmed death ligand 1 (PD-L1), we distinguished two functionally transcriptionally distinct neutrophil subsets in lungs mice infected with mycobacteria. Inflammatory [MHC-II − , PD-L1 lo ] neutrophils produced inflammasome-dependent IL-1β response to virulent mycobacteria “accelerated” inflammation, which was highly exacerbated IFN-γR −/− mice. Regulatory + hi “brake”...