A5030836487- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Metabolomics and Mass Spectrometry Studies
- Environmental DNA in Biodiversity Studies
- Plant Pathogens and Resistance
- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Tryptophan and brain disorders
- Genomics and Rare Diseases
- Genomics and Phylogenetic Studies
Sechenov University
2023-2024
Engelhardt Institute of Molecular Biology
2023-2024
International Tomography Center
2023
The evolution of protein-coding genes has both structural and regulatory components. first can be assessed by measuring the ratio non-synonymous to synonymous nucleotide substitutions. second component measured as normalized proportion transposable elements that are used elements. For time, we characterized in parallel evolutionary profiles for 10,890 human 2972 molecular pathways. We observed a ~0.1 correlation between metrics at gene level, which appeared much higher (~0.4) pathway level....
Alzheimer's disease (AD) is the most common type of dementia in elderly. Incomplete knowledge about pathogenesis this determines absence medications for treatment AD today. Animal models can provide necessary to understand mechanisms biochemical processes occurring body health and disease.
RNA polymerase II (POL II) is responsible for the transcription of messenger RNAs (mRNAs) and long non-coding (lncRNAs). Previously, we have shown evolutionary invariance structural features DNA in POL core promoters precursors mRNAs. In this work, analyzed lncRNAs Homo sapiens Mus musculus genomes. Structural analysis nucleotide sequences positions -50, +30 bp relation to TSS extremely heterogeneous 3D structure that includes two singular regions - hexanucleotide "INR" around octanucleotide...
RNA polymerase III (Pol III) transcribes tRNA genes using type II promoters. The internal control regions contain a Box A and B, which are recognized by TFIIIC. 5'-flanking of clearly play role in the regulation transcription, but consensus sequences it have been found only some plants