A5023023968- DNA Repair Mechanisms
- Bioinformatics and Genomic Networks
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- Immune cells in cancer
- Cancer Risks and Factors
- PI3K/AKT/mTOR signaling in cancer
- Glioma Diagnosis and Treatment
- Medical and Agricultural Research Studies
- DNA and Nucleic Acid Chemistry
- Nutrition, Genetics, and Disease
- Studies on Chitinases and Chitosanases
- Microbial Natural Products and Biosynthesis
- Brain Metastases and Treatment
- Tryptophan and brain disorders
- Mycobacterium research and diagnosis
- Immune responses and vaccinations
- Microbial Metabolism and Applications
- Genomics and Rare Diseases
- Protein Kinase Regulation and GTPase Signaling
Sechenov University
2021-2024
Moscow Institute of Physics and Technology
2023-2024
Endocrinology Research Center
2024
Krasnoyarsk Regional Clinical Hospital
2016-2020
The evolution of protein-coding genes has both structural and regulatory components. first can be assessed by measuring the ratio non-synonymous to synonymous nucleotide substitutions. second component measured as normalized proportion transposable elements that are used elements. For time, we characterized in parallel evolutionary profiles for 10,890 human 2972 molecular pathways. We observed a ~0.1 correlation between metrics at gene level, which appeared much higher (~0.4) pathway level....
Dual inhibitors of HER2 and EGFR, such as lapatinib, have shown significant efficacy for the therapy HER2-positive breast cancer. Previous experiments showed that in cell cultures, lapatinib was significantly reduced by exposure to human serum epidermal growth factor (EGF). At proteomic transcriptomic levels, we examined changes cancer line SK-BR-3 profiles upon treatment with either alone or combination EGF. Proteomic profiling revealed 350 differentially expressed proteins (DEPs) response...
Glioblastoma (GBM) is the most aggressive and lethal central nervous system (CNS) tumor. The treatment strategy mainly surgery and/or radiation therapy, both combined with adjuvant temozolomide (TMZ) chemotherapy. Historically, methylation of
The aim of present study was to investigate the relationship between phenotypic features monocytes and intensity "respiratory burst" in patients with renal cell carcinoma (RCC). A total 73 RCC (Т3N0М0, clear type) participated study. Phenotyping blood performed by flow cytometry. level determined using spontaneous zymosan-induced luminol- lucigenin-dependent chemiluminescence. Suffficient changes structure were identified peripheral patients. Alterations monocytic subpopulations...
Background: pathogen heterogeneity and complexity are the main obstacles for schizophrenia autism spectrum disorders (ASD) differential diagnosis in children. The role of oxidative stress molecular mechanisms pathogenesis is beyond doubt. Free radicals that accumulate during can cause modifications formation breaks сell-free DNA (cfDNA) nuclear blood cells. To date, it has been proven 8-hydroxy-2’- deoxyguanosine (8-OHdG) be considered as an biomarker. However, still unclear how pronounced...
Aim. Study of the molecular and genetic features MRSA, causative agents purulent diseases at cancer patients. Materials methods. In work were used - bacteriological method, methods (PCR, M-PCR, sequencing). Results. MRSA share among staphylococcal infections patients in 2003 2007 has made 37,6%, 2010 2015 increased up to 51,3%. At a research allocated MRS A ] strains, have established, existence two main clones: ST239/spa3(t037)/SCCmecIIIA ST8/ . spal(t008)/SCCmecIVc. Representatives clones...
The aim of our study was to investigate the relationship between phenotype and «respiratory burst» activity neutrophilic granulocytes in patients with renal cancer. included 73 cell carcinoma (T3N0M0, clear-cell type) before surgical treatment at age 40-55 years. diagnosis renal cancer histologically verified all patients. Fifty healthy age-matched persons were involved as a control group. Phenotyping blood performed by flow cytometry. respiratory burst evaluated using spontaneous...
The TERT gene encodes the reverse transcriptase subunit of telomerase and is normally transcriptionally suppressed in differentiated human cells but reactivated cancers where its expression frequently associated with poor survival prognosis. Here we experimentally assessed RNA sequencing patterns transcription 1039 cancer samples 27 tumor types. We observed a bimodal distribution ∼27% did not express rest showed bell-shaped distribution. Expression strongly correlated 1443 genes including...
The differential ratio of nonsynonymous to synonymous nucleotide substitutions (dN/dS) is a common measure the rate structural evolution in proteincoding genes. In addition, we recently suggested that proportion transposable elements gene promoters host functional genomic sites serves as marker regulatory Such regions may include transcription factor binding and modified histone loci.
The metabolism of zinc and manganese plays a pivotal role in cancer progression by mediating cell growth metastasis. SLC30A family proteins
Inorganic polyphosphates and respective metabolic pathways enzymes are important factors for yeast active growth in unfavorable conditions. However, particular proteins of polyphosphate metabolism remain poorly explored this context. Here we report biochemical transcriptomic characterization the CRN/PPN2 strain (derived from Ppn1-lacking CRN strain) overexpressing studied Ppn2 polyphosphatase. We showed that overexpression significantly reduced lag phase alkaline medium presumably due to...
The problem of microbial antibiotic resistance and investigation its underlying mechanisms is paramount importance for all fields clinical medicine, including oncology. aim the study was to examine major pathogens causing purulent-inflammatory complications in cancer patients. Materials methods. In 2012—2015 there conducted a prospective examination 184 patients, 67 patients at Department Surgery no. 1 117 Intensive Care Unit Krasnoyarsk Regional Clinical Oncology Center named after A.I....