A5078922736- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- Cervical Cancer and HPV Research
- Ethics in Clinical Research
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- HIV/AIDS drug development and treatment
- Adolescent Sexual and Reproductive Health
- Diverse Scientific Research Studies
- Syphilis Diagnosis and Treatment
- COVID-19 Pandemic Impacts
- HIV/AIDS oral health manifestations
- HIV/AIDS Impact and Responses
- Chronic Lymphocytic Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Neonatal Health and Biochemistry
- COVID-19 epidemiological studies
- HIV-related health complications and treatments
- Sex work and related issues
- Hematological disorders and diagnostics
Erasmus MC
2020-2025
Erasmus University Rotterdam
2021-2022
Leiden University Medical Center
2021
Structured abstract for full paper Background After recovery from COVID-19, most patients have anti-SARS-CoV-2 neutralizing antibodies. Their convalescent plasma could be an inexpensive and widely available treatment COVID-19. Methods The Convalescent-plasma-for-COVID (ConCOVID) study was a randomized trial comparing with standard of care therapy in hospitalized COVID-19 the Netherlands. Patients were 1:1 received 300ml antibody titers at least 1:80. primary endpoint day-60 mortality key...
Abstract In a randomized clinical trial of 86 hospitalized COVID-19 patients comparing standard care to treatment with 300mL convalescent plasma containing high titers neutralizing SARS-CoV-2 antibodies, no overall benefit was observed. Using comprehensive translational approach, we unravel the virological and immunological responses following disentangle which may should be focus future studies. Convalescent is safe, does not improve survival, has effect on disease course, nor enhance viral...
Undiagnosed HIV infection is a prominent clinical issue throughout Europe that requires the continuous attention of all healthcare professionals and policymakers to prevent missed testing opportunities late diagnosis. This systematic review aimed evaluate interventions increase rates case detection in European hospitals. Out 4598 articles identified, 29 studies fulfilled selection criteria. Most were conducted single Western capital cities, only one study was from Eastern Europe. The main...
To study the effect of interferon-α2 auto-antibodies (IFN-α2 Abs) on clinical and virological outcomes in critically ill COVID-19 patients risk IFN-α2 Abs transfer during convalescent plasma treatment.
The potential benefit of convalescent plasma (CP) therapy for coronavirus disease 2019 (COVID-19) is highest when administered early after symptom onset. Our objective was to determine the effectiveness CP in improving course COVID-19 among high-risk outpatients.A multicentre, double-blind randomized trial conducted comparing 300 mL with non-CP. Patients were ≥50 years, symptomatic <8 days, had confirmed RT-PCR or antigen test result and at least one risk factor severe COVID-19. primary...
Develop and validate a strategy to improve HIV testing rates using teams. A prospective clinical trial was conducted from January 2020 July 2023 in two Dutch university hospitals. The intervention involved implementing teams provide peer awareness, education, feedback physicians treating patients ≥18 years newly diagnosed with indicator conditions. primary outcome the rate. Secondary outcomes included by specialty, prevalence, reasons for withholding testing. Of 313,666 registered diagnoses,...
Twenty-five B-cell-depleted patients (24 following anti-CD19/20 therapy) diagnosed with coronavirus disease 2019 had been symptomatic for a median of 26 days but remained antibody negative. All were treated convalescent plasma high neutralizing titers. Twenty-one (84%) recovered, indicating the potential therapeutic effects this therapy in particular population.
Chronic kidney disease (CKD) is an important sequela of hematopoietic stem cell transplantation (HSCT), but data regarding CKD after pediatric HSCT are limited. In this single center cohort study, we evaluated the estimated glomerular filtration rate (eGFR) dynamics, proteinuria and hypertension in first decade assessed risk factors for 216 survivors, transplanted 2002-2012. The eGFR decreased from a median 148 to 116 ml/min/1.73 m2 between pre-HSCT ten years post-HSCT. (KDIGO stages G2 or...
Abstract During COVID-19 lockdown, the in-hospital number of HIV indicator conditions decreased disproportionally compared with other non–COVID-19 diseases, which was accompanied by reduced testing rates, and proportion positive tests, new referrals, more late presentation after lockdown cessation, indicating a significantly impacted care continuum.
BackgroundAdequate identification and testing of people at risk for HIV is fundamental the care continuum. A key strategy to improve timely indicator condition (IC) guided testing.AimTo evaluate uptake recommendations in IC-specific guidelines European countries.MethodsBetween 2019 2021, experts reviewed guideline databases identify all national 62 ICs. The proportion IC recommending was reported, stratified by subgroup (HIV IC, country, eastern/western Europe, achievement 90-90-90 goals...
Abstract People with HIV continue to experience stigma. Quantitative data on stigma perpetrated by healthcare providers of hospitals providing care in high-income countries are limited. The aim this study is investigate factors associated Dutch settings from the providers’ perspective. We conducted a cross-sectional using questionnaire ‘Measuring Stigma and Discrimination Among Health Facility Staff – Monitoring Tool for Global Indicators’ assess among (n = 405) two academic hospitals....
Abstract Background Convalescent plasma (CP) for hospitalized patients with COVID-19 has not demonstrated clear benefits. However, data on outpatients early symptoms are scarce. We aimed to assess whether treatment CP administered during the first 7 days of reduced disease progression or risk hospitalization outpatients. Methods Two double-blind randomized trials ( NCT04621123 , NCT04589949 ) were merged pooling starting when <20% their predefined sample size had been recruited. A...
Abstract Convalescent plasma could be an inexpensive and widely available treatment for COVID-19 patients but reports on effectiveness are inconclusive. We collected convalescent from donors with high titers of neutralizing anti-SARS-CoV-2 antibodies effectively blocking SARS-CoV-2 infection in vitro. In a randomized clinical trial 86 patients, no overall benefit 300 mL was found hospitalized the Netherlands. Using comprehensive translational approach, we unraveled virological immunological...
Abstract Background Confirming the efficacy of dolutegravir/lamivudine in clinical practice solidifies recommendations on its use. Methods Prospective cohort study (DUALING) 24 human immunodeficiency virus (HIV) treatment centers Netherlands. HIV RNA–suppressed cases were triple-drug antiretroviral regimens without prior virological failure or resistance and started dolutegravir/lamivudine. Cases 1:2 matched to controls by use dolutegravir-based regimens, age, sex, transmission route, CD4+...
Cervical cancer and its precursor are labeled as HIV indicator conditions, justifying the recommendation of testing for all patients. This study aimed to assess acceptance patients' gynecologists' perceptions on in patients with cervical dysplasia at colposcopy outpatient clinic hospitals Netherlands.
Abstract Background HIV indicator condition-guided testing is recommended by guidelines to identify undiagnosed infections. However, general practitioners (GPs) frequently see patients for conditions without them HIV. The aim of this study was evaluate whether implementing teams, using trained GP ambassadors, promoted local practices in urban centers the Netherlands. Methods We conducted a prospective implementation between May 2021 and March 2023. Patients ≥ 18 years newly diagnosed with...
Background: After SARS-CoV-2 reached the Netherlands in February 2020, rapid interventions were taken to mitigate viral spread and optimise care for COVID-19 patients. Lockdowns downscaling of regular healthcare practices necessary. The effect these on HIV are uncertain. We assessed impact nationwide lockdown March May during first wave diagnosis linkage care.Methods: An observational study was conducted at Erasmus MC, a regional reference tertiary hospital Netherlands. All patients ≥ 18...
<h3>Introduction/Background*</h3> Cervical dysplasia is an HIV indicator condition and according international recommendations testing strongly advised in women with cervical dysplasia, because the risk of undiagnosed thought to be >0.1%. Therefore test should offered all dysplasia. There no literature about opinion Gynaecologist on screening patients <h3>Methodology</h3> We sent online questionnaire gynecologist South West Netherlands investigate 1) what they know this issue, 2) their...
Abstract Purpose: To study the effect of Interferon-α auto-antibodies (IFN-α Abs) on clinical and virological outcomes in critically ill COVID-19 patients risk IFN-α Abs transfer during convalescent plasma treatment. Methods: Sera from cases other respiratory illness were tested for IFN-αAbs by ELISA bioassay. Abslevels compared between critically, severely moderately groups both acute stages. Longitudinal analyses performed to determine whether levels change after transfusion. Results:...