A5070362299- Bacillus and Francisella bacterial research
- Herpesvirus Infections and Treatments
- Poxvirus research and outbreaks
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Zoonotic diseases and public health
- SARS-CoV-2 detection and testing
- CRISPR and Genetic Engineering
- Antibiotic Resistance in Bacteria
- interferon and immune responses
- COVID-19 diagnosis using AI
- Mosquito-borne diseases and control
Research Institute for Tropical Medicine
2022-2024
Abstract The Omicron severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant led to a dramatic global epidemic wave following detection in South Africa November 2021. BA.1 lineage was dominant and responsible for most SARS-CoV-2 outbreaks countries around the world during December 2021–January 2022, while other lineages, including BA.2, accounted minority of isolates. Here, we describe Philippines by analysing genomic data. Our results identify presence both BA.2 lineages 2021,...
We report the first travel-related case of a possible Mpox-Varicella zoster virus (VZV) co-infection in Philippines, country that is endemic for Varicella but non-endemic Mpox. A 29-year-old Filipino, female, with travel history to Switzerland and no prior VZV infection sought consultation due rashes. She presented multiple papular, pustular, vesicular skin lesions, some umbilication irregular borders, on face, neck, trunk, inguinal area, upper extremities, right leg. also had bilateral...
ABSTRACT Co-infection with multiple SARS-CoV-2 variants, though rare, may have clinical and public health implications, including facilitating variant recombination. Early detection of co-infections is therefore crucial. In this study, we report two probable cases co-infection identified during routine genomic surveillance. Initially suspected as cross-contamination due to the presence private mutations nucleotide mixtures flagged by Nextclade bammix, samples were re-extracted resequenced...
ABSTRACT Whole genome sequencing (WGS) is used extensively in identifying SARS-CoV-2 variants. However, this method requires stringent sample acceptance criteria, long turn-around time (TAT), expensive processing and maintenance costs, highly skilled staff. Although offers comprehensive pathogen insights, a cost-effective tool with faster TAT beneficial detecting variants of concern (VOCs). Here, we single nucleotide polymorphism (SNP) RT-qPCR assay to detect the N501Y mutation banked RNA...
We report a case of 31-year-old Filipino male with travel history to several European countries in July 2022. He developed five non-tender, well-defined, umbilicated pustules erythematous borders on the upper lip, left gluteal area, bilateral knees, and ankle. Skin punch biopsy findings were suggestive viral infection. Mpox infection from Clade II (previously known as West African clade) was confirmed by detecting amplifying G2R_G, G2R_WA C3L gene targets using qPCR. Shotgun metagenomic...
The Philippines has had a rapidly growing human immunodeficiency virus (HIV) epidemic with shift in the prevalent subtype from B to CRF01_AE. However, phylodynamic history of CRF01_AE yet be reconstructed. We conducted descriptive retrospective study reconstructing HIV-1 transmissions through molecular epidemiology. Partial polymerase sequences (n = 1144) collected between 2008 and 2018 three island groups were collated Research Institute for Tropical Medicine drug resistance genotyping...
Abstract BACKGROUND Following the detection of first laboratory-confirmed Monkeypox (MPXV) infection in Philippines, guidelines on diagnosis, treatment, and prevention have been strengthened to further help healthcare providers differentiating it properly from other diseases with similar clinical presentation, one which is Varicella zoster (VZV) infection. Interestingly, co-infection has previously reported endemic countries. We then report travel-related case MPXV-VZV a country that for but...
Abstract The Omicron SARS-CoV-2 variant led to a dramatic global epidemic wave following detection in South Africa November, 2021. lineage BA.1 was dominant and responsible for most domestic outbreaks during December 2021-January 2022, whilst other lineages including BA.2 accounted the minority of isolates. Here, we describe Philippines by analysing genomic data. Our results identify presence both 2021, before cases surged January 2022. We infer that only underwent sustained transmission...
Abstract The Philippines has had a rapidly growing HIV epidemic with shift in the prevalent subtype from B to CRF01_AE. However, phylodynamic history of CRF01_AE yet be reconstructed. We conducted descriptive retrospective study reconstructing HIV-1 transmissions through molecular epidemiology. Partial polymerase sequences ( n = 1429) collected between 2008 and 2018 13 Philippine regions were collated RITM drug resistance genotyping database. Subsampling was performed on these Los Alamos...
<title>Abstract</title> <italic>Background:</italic> With the World Health Organization’s declaration of 2022 multi-country monkeypox outbreak as a Public Emergency International Concern (PHEIC), we report first confirmed case infection in Filipino with clinical presentation different from classic cases previously reported endemic countries Central and West Africa before outbreak. We describe infection's gross dermatopathological appearances on Southeast Asian brown skin. also discuss...
Abstract Background With the World Health Organization’s declaration of 2022 multi-country monkeypox outbreak as a Public Emergency International Concern (PHEIC), we report first confirmed case infection in Filipino with clinical presentation different from classic cases previously reported endemic countries Central and West Africa before outbreak. We describe infection's gross dermatopathological appearances on Southeast Asian brown skin. also discuss detailed process quantitative real-time...
<title>Abstract</title> <italic>Background:</italic> With the World Health Organization’s declaration of 2022 multi-country monkeypox outbreak as a Public Emergency International Concern (PHEIC), we report first confirmed case infection in Filipino with clinical presentation different from classic cases previously reported endemic countries Central and West Africa before outbreak. We describe infection's gross dermatopathological appearances on Southeast Asian brown skin. also discuss...