A5106418280- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Circular RNAs in diseases
- Cancer Research and Treatments
- Extracellular vesicles in disease
- Renal and related cancers
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
Baotou Medical College
2024-2025
Inner Mongolia University of Science and Technology
2024-2025
Shandong Maternal and Child Health Hospital
2024
Fudan University Shanghai Cancer Center
2023-2024
Shanghai Medical College of Fudan University
2023-2024
MARCH8, an E3 ubiquitin ligase, plays a crucial role in regulating various cellular processes such as protein degradation and signaling pathways is implicated the development spread of pancreatic cancer. Analysis cancer tissues compared to adjacent normal showed decrease miRNA-30d-5p levels increase OIP5-AS1 MARCH8 levels, confirmed by qRT-PCR Western blot analysis. The dual-luciferase reporter assay demonstrated binding relationship between miRNA-30d-5p, well PACN-1 cells, derived from...
The role E3 ubiquitin ligase membrane-associated RING-CH 8 (MARCH8) has not been studied in pancreatic cancer.Pancreatic cancer cell lines and the normal cells were tested vitro studies male athymic nude mice vivo studies. Measuring viability by Cell Counting Kit-8 assay (CCK8), 5-ethynyl-2'- deoxyuridine (Edu) staining, colony formation assay. Wound healing was implemented for migration Transwell performed invasion to evaluate histological status hematoxylin eosin staining detect protein...
The response of gastric cancer (GC) patients to first-line programmed cell death 1 (PD-1) blockade and S-1 plus oxaliplatin (SOX) chemotherapy varies considerably, the underlying mechanisms driving this variability remain elusive. Exosomal microRNAs (miRNAs or miRs) have emerged as potential biomarkers for efficacy prediction due their roles in GC biology stable expression serum. In study, we aimed identify predict patients' anti-PD-1 therapy further elucidate by which these exosomal miRNAs...
Gastric cancer has a high incidence rate worldwide; it is particularly important to determine the therapeutic efficacy of available treatments and prognosis gastric due its insidious onset lack specific symptoms in early stage (most patients are diagnosed middle or late stage). Recent studies have revealed that altered expression microRNAs plays pivotal role immune checkpoints various cellular processes cancer. miRNAs gradually become biomarkers targets because their specificity sensitivity....