A5100658772- Antimicrobial Peptides and Activities
- Organic Electronics and Photovoltaics
- Organic Light-Emitting Diodes Research
- Biochemical and Structural Characterization
- Magnetic properties of thin films
- Chemical Synthesis and Analysis
- Conducting polymers and applications
- Luminescence and Fluorescent Materials
- Perovskite Materials and Applications
- Cancer-related molecular mechanisms research
- Heusler alloys: electronic and magnetic properties
- Physics of Superconductivity and Magnetism
- 2D Materials and Applications
- Environmental Toxicology and Ecotoxicology
- Nanowire Synthesis and Applications
- Antimicrobial agents and applications
- Topological Materials and Phenomena
- Ferroptosis and cancer prognosis
- Opinion Dynamics and Social Influence
- Complex Network Analysis Techniques
- Terahertz technology and applications
- Insect and Pesticide Research
- Aerodynamics and Fluid Dynamics Research
- Genomics, phytochemicals, and oxidative stress
- Magneto-Optical Properties and Applications
Fudan University
2019-2025
Northeast Normal University
2025
Lanzhou University
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Peking University Cancer Hospital
2023
Peking University
2023
Xi'an University of Architecture and Technology
2022
Zhejiang Normal University
2018-2019
Jilin University
2005-2017
Jilin Medical University
2015-2017
The development and progression of hepatocellular carcinoma (HCC) are dependent on its local microenvironment. Hypoxia inflammation two critical factors that shape the HCC microenvironment; however, interplay between involvement cancer cells under such conditions remain poorly understood. We found tumor‐associated macrophages, primary proinflammatory within tumors, secreted more interleukin 1β (IL‐1β) moderate hypoxic due to increased stability hypoxia inducible factor 1α (HIF‐1α). Under...
Influence maximization problem aims to identify the most influential individuals so as help in developing effective viral marketing strategies over social networks. Previous studies mainly focus on designing efficient algorithms or heuristics a static network. As matter of fact, real-world networks keep evolving time and recalculation upon changed network inevitably leads long running time. In this paper, we propose an incremental approach, IncInf, which can efficiently locate top-<mml:math...
Two AIE-type emitters that can realize efficient deep-blue OLEDs with the CIE coordinates matching well standard blue-light coordinate of (0.14, 0.08) have been designed and synthesized.
The emergence of multidrug-resistant bacteria has major issues for treating bacterial pneumonia. Currently, anoplin (GLLKRIKTLL-NH2) is a natural antimicrobial candidate derived from wasp venom. In this study, series new peptide (AMP) analogues were designed and synthesized. relationship between their biological activities positive charge, hydrophobicity, amphipathicity, secondary structure are described. characteristic shared by these peptides that positively charged amino acids hydrophobic...
The ongoing emergence of antibiotic-resistant pathogens had been dramatically stimulating and accelerating the need for new drugs. PE2 is a kind cyclic lipopeptide with broad-spectrum antimicrobial activity. Herein, its structure–activity relationship was systematically investigated by employing 4 analogues 23 linear first time. screened 26 27 bearing different fatty acyls at N-termini Tyr residue 9th position superior potency compared to showed equivalent activity PE2. Notably, exhibited...
Antimicrobial peptides (AMPs) have emerged as promising agents to combat the antibiotic resistance crisis due their rapid bactericidal activity and low propensity for drug resistance. However, AMPs face challenges in terms of balancing enhanced antimicrobial efficacy with increased toxicity during modification processes. In this study, de novo d-type β-hairpin are designed. The conformational transformation self-assembling peptide
A novel multifunctional 1,6-bis(2-hydroxyphenyl)pyridine boron bis(4-n-butyl-phenyl)phenyleneamine compound in which the hole-transporting (HT), electron-transporting (ET), and emitting (EM) components are integrated into a single molecule was synthesized used as an material to fabricate efficient single-layer electroluminescent device.
The emergence of multidrug-resistant bacteria has dramatically increased the lethality, level resistance, and difficulty treatment. In this study, a series new antimicrobial peptides (AMPs) based on β-hairpin structure with template (XY)2RRRF(YX)2-NH2 (X: hydrophobic amino acids; Y: cationic acids) were synthesized; surprisingly, almost all have strong antibacterial activity negligible hemolytic toxicity. Particularly, therapeutic index (TI) values F(RI)2R F(KW)2K reached up to 115.9 70.7,...
Cervical cancer poses a substantial threat to women's health, underscoring the necessity for effective therapeutic agents with low toxicity that specifically target cells. As progresses, increased glucose consumption causes scarcity in tumor microenvironment (TME). Consequently, it is imperative identify pharmacological capable of effectively killing cells under conditions availability within TME. Previous studies showed Gboxin, small molecule, inhibited glioblastoma (GBM) growth by...
The formation of large polarons resulting from the Fröhlich coupling photogenerated carriers with polarized crystal lattice is considered crucial in shaping outstanding optoelectronic properties hybrid organic-inorganic perovskite crystals. Until now, initial polaron dynamics after photoexcitation have remained elusive system. Here, based on terahertz time-domain spectroscopy and optical-pump probe, we access nature interplay between photoexcited unbound charge optical phonons MAPbBr
Nonselective toxicity of antimicrobial peptides (AMPs) needs to be solved urgently for their application. Temporin-PE (T-PE, FLPIVAKLLSGLL-NH2), an AMP extracted from skin secretions frogs, has high and specific activity against Gram-positive bacteria. To improve the performance T-PE, a series T-PE analogues were designed synthesized by glutamic acid full-scan, then key positions replaced with lysine. Finally, E11K4K10, highest therapeutic indicial AMP, was screened out. E11K4K10 not easy...
By using blue-emissive diboron complexes with bis-spiro structures as emitting layers, the most efficient blue OLEDs based on four-coordinate organoboron compounds have been achieved.
Two phenanthro[9,10-<italic>d</italic>]imidazole (PI) derivatives, DPAA-PPI and<italic>t</italic>BuDPAA-PPI, were synthesized. The non-doped OLEDs with and<italic>t</italic>BuDPAA-PPI as emitters displayed very low driving voltages, high brightness and maximum external quantum efficiencies (EQE) of 5.2% 4.1%, respectively.
Developing a straightforward and effective strategy to modify antimicrobial peptides (AMPs) is crucial in overcoming the challenges posed by their instability toxicity. Phosphorylation can reduce toxicity improve stability of AMPs. Based on these, we designed series corresponding phosphorylated forms. The results showed that all displayed reduced enhanced compared unphosphorylated counterparts. Among them, W3BipY8-P stood out as most promising peptide, exhibiting similar antibacterial...
Two iridium complexes with N^C^N-coordinated terdentate ligands exhibit high PE and EQE values of 35.5 lm W<sup>−1</sup> & 15.8% for blue-green emission, 47.4 16.7% green emission <italic>via</italic> direct charge recombination on both dopant emitters in the bipolar host–dopant systems.
A spintronic terahertz (THz) emitter based on rare-earth-transition-metal ferrimagnetic alloys has drawn wide attention due to its prominent THz emission signals at a magnetic compensated state. Here, spectroscopy is performed in layered ferrimagnetic/nonmagnetic structure of Ta/Tbx(FeCo)1–x/Pt investigate the impact magnetization and spin polarization radiation. Composition temperature-dependent are observed by an inverse Hall effect. The variation amplitude approximately follows in-plane...
In this study, significant modulations of perpendicular magnetic anisotropy, spin–orbit torque (SOT) efficiency (ξSH), and damping have been achieved in Pt/Co/Ta films after inserting an insulating NiO underlayer. As the thickness (tNiO) varies from 0 to 2 nm, ξSH exhibits a nonmonotonic variation trend, initially increasing then decreasing reaching maximum value at tNiO = 1 nm. The SOT is as high 0.60, nearly twice large that sample without NiO. Based on dependencies effective anisotropy...