A5009371458- Antimicrobial Peptides and Activities
- Peptidase Inhibition and Analysis
- Molecular Junctions and Nanostructures
- Chemical Synthesis and Analysis
- Biochemical and Structural Characterization
- Nanocluster Synthesis and Applications
- Antimicrobial agents and applications
- Quantum and electron transport phenomena
- 2D Materials and Applications
- Nonlinear Optical Materials Studies
- Surface Chemistry and Catalysis
- Nanopore and Nanochannel Transport Studies
- Innovative Educational Techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Aquaculture disease management and microbiota
- Reproductive Health and Contraception
- RNA modifications and cancer
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Plasmonic and Surface Plasmon Research
- Graphene research and applications
- Advanced biosensing and bioanalysis techniques
- Cancer-related gene regulation
- RNA Interference and Gene Delivery
- Topological Materials and Phenomena
Lanzhou University
2011-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
New York University Press
2022-2023
Cambridge University Press
2022-2023
Affiliated Hospital of Nantong University
2022
Nantong University
2022
Capital Medical University
2021
The First People’s Hospital of Lianyungang
2018-2020
Beijing Computational Science Research Center
2019-2020
Xuzhou Medical College
2018
Anticancer peptides (ACPs) are promising antitumor resources, and developing acid-activated ACPs as more effective selective drugs would represent new progress in cancer therapy. In this study, we designed a class of hybrid LK-LE by altering the charge shielding position anionic binding partner LE based on cationic ACP LK investigated their pH response, cytotoxic activity, serum stability, hoping to achieve desirable acid-activatable ACP. As expected, obtained could be activated exhibit...
Developing a straightforward and effective strategy to modify antimicrobial peptides (AMPs) is crucial in overcoming the challenges posed by their instability toxicity. Phosphorylation can reduce toxicity improve stability of AMPs. Based on these, we designed series corresponding phosphorylated forms. The results showed that all displayed reduced enhanced compared unphosphorylated counterparts. Among them, W3BipY8-P stood out as most promising peptide, exhibiting similar antibacterial...
Nonadiabatic excited state molecular dynamics underpin many photophysical and photochemical phenomena, such as exciton dynamics, charge separation transport. In this work, we present an efficient nonadiabatic (NAMD) simulation method based on time-dependent density functional tight-binding (TDDFTB) theory. Specifically, the adiabatic electronic structure, essential NAMD input, is described at TDDFTB level. The effects originating from coupled motions of electrons nuclei are treated by...
Deoxyribonucleic acid (DNA) sequencing has found wide applications in medicine including treatment of diseases, diagnosis and genetics studies. Rapid cost-effective DNA been achieved by measuring the transverse electronic conductance as a single-stranded is driven through nanojunction. With aim improving accuracy sensitivity sequencing, we investigate electron transport properties nucleobases within gold nanogaps based on first-principles quantum simulations. Considering fact that bases can...
Antimicrobial peptides (AMPs) possess strong antibacterial activity and low drug resistance, making them ideal candidates for bactericidal drugs addressing the issue of traditional antibiotic resistance. In this study, a template (G(XXKK)
Hot carriers generated from the decay of plasmon excitation can be harvested to drive a wide range physical or chemical processes. However, their generation efficiency is limited by concomitant phonon-induced relaxation processes which energy in excited transformed into heat. simulations dynamics nanoscale clusters are challenging due computational complexity involved. Here, we adopt our newly developed Trajectory Surface Hopping (TSH) nonadiabatic molecular algorithm simulate Au20 clusters,...
Tunneling electron-induced light emission in scanning tunneling microscopy (STM) has recently been explored as a novel source with tunable properties. Here, using first-principles-based atomistic simulations, we study the STM-induced luminescence of single free-base phthalocyanine (H2Pc) molecule and propose way to control frequency STM molecular junction by precisely controlling charge injection at different positions. The is found be directly related spatial distribution states thus...
Graphene nanoribbons (GNRs) with atomically precise heterojunction interfaces are exploited as nanoscale light emitting devices modulable emission frequencies. By connecting GNRs different widths and lengths, topological boundary states can be formed manipulated. Using first-principles-based atomistic simulations, we studied the luminescence properties of a STM GNR junction explored applications these sources. Taking advantage ultrahigh resolution tip, direct injection high energy carriers...
Abstract Repeated implantation failure (RIF) greatly influences pregnancy rate after assisted reproductive technologies (ART) with elusive causes. Our study aimed to explore coagulation parameters in association RIF and establish a model predict the risk of Chinese women. Coagulation parameters, including prothrombin time (PT), thrombin (TT), activated partial (APTT), D-dimer (DD), fibrin degradation products (FDP), fibrinogen (FG), platelet aggregation induced by arachidonic acid (AA)...
The m7G modification has been proven to play an important role in RNA post-transcriptional and protein translation. However, the potential of patterns assessing prognosis Skin cutaneous melanoma (SKCM) tumor microenvironment (TME) not well studied. In this study, we investigated finally identified 21 available m7G-related genes. We used hierarchical clustering (K-means) classify 743 SKCM patients into three m7G-modified subtypes named m7G/gene cluster-A, B, C. found that both cluster B gene...
Improving the cell selectivity of anticancer peptides (ACPs) is a major hurdle in their clinical utilisation. In this study, new acid-activated ACP was designed by conjugating cationic LK to its anionic binding partner peptide (LEH) via disulphide linker trigger antitumor activity at acidic pH while masking killing normal pH. Three containing different numbers glutamic acid (Glu) and histidine were engineered obtain an efficient ACP. The conjugates LK-LEH2 LK-LEH3 exhibited 6.1- 8.0-fold...
Understanding photon-electron conversion on the nanoscale is essential for future innovations in nano-optoelectronics. In this article, based nonequilibrium Green's function (NEGF) formalism, we develop a quantum-mechanical method modeling energy optoelectronic devices. The allows us to study photoinduced charge transport and electroluminescence processes realistic First, investigate properties of two-level model with two different treatments inelastic scatterings. We show regime where...
Biological probes with integrated photoluminescence and magnetism characteristics play a critical role in modern clinical diagnosis surgical protocols combining fluorescence optical imaging (FOI) magnetic resonance (MRI) technology. However, traditional semiconductors can easily generate spin splitting at the Fermi level half-metallic electronic occupation, which will sharply reduce radiation recombination efficiency of photogenerated carriers. To overcome this intrinsic contradiction, we...
As the basic course of economy and management, content macroeconomics is abstract, it involves a wide range knowledge, effect classroom teaching quality evaluation not satisfactory.There are lot problems in teaching, for example, difficult to apply practice, reform continue attract students interest, assessment methods outdated.Not clear about purpose learning, unfamiliar with macroeconomic operation lack interest led above problems.Therefore, introduction real-time multimedia data, seize...
Objective To explore the effect of simulation-based diagnosis and treatment in obstetrics gynecology teaching. Methods 62 clinical medical students five-year program, grade 2012, Xuzhou Medical University were divided into two groups randomly, 32 experimental group 30 control group. The added a course treatment, while received regular teaching. Each was examined, investigated evaluated for grades satisfaction degree. Results There no significant difference between scores writing...