A5065668694- Antimicrobial Peptides and Activities
- Chemical Synthesis and Analysis
- Biochemical and Structural Characterization
- Pharmacological Effects of Natural Compounds
- Peptidase Inhibition and Analysis
- Antimicrobial agents and applications
- Neuropeptides and Animal Physiology
- Probiotics and Fermented Foods
- RNA Interference and Gene Delivery
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Advanced biosensing and bioanalysis techniques
- Advanced Drug Delivery Systems
- Insect and Pesticide Research
- Synthetic Organic Chemistry Methods
- Supramolecular Self-Assembly in Materials
- Bioactive Compounds and Antitumor Agents
- Asymmetric Synthesis and Catalysis
- Pediatric health and respiratory diseases
- Bacteriophages and microbial interactions
- Polydiacetylene-based materials and applications
- Toxin Mechanisms and Immunotoxins
- Immune Response and Inflammation
- Antibiotic Resistance in Bacteria
- Aquaculture disease management and microbiota
Lanzhou University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Academy of Medical Sciences
2023
Macau University of Science and Technology
2020-2022
State Institute for Drug Control
2006
Lanzhou City University
2004
An organocatalytic Michael–Michael cascade for the enantioselective construction of spirocyclopentane bioxindoles was developed in moderate to good yield with diastereoselectivities and excellent enantioselectivities. The straightforward process, catalyzed by a bifunctional chiral squaramide catalyst, serves as powerful tool potentially biological four contiguous centers, which two are spiro all-carbon quaternary centers on single cyclopentane ring.
The emergence of multidrug-resistant bacteria has major issues for treating bacterial pneumonia. Currently, anoplin (GLLKRIKTLL-NH2) is a natural antimicrobial candidate derived from wasp venom. In this study, series new peptide (AMP) analogues were designed and synthesized. relationship between their biological activities positive charge, hydrophobicity, amphipathicity, secondary structure are described. characteristic shared by these peptides that positively charged amino acids hydrophobic...
The ongoing emergence of antibiotic-resistant pathogens had been dramatically stimulating and accelerating the need for new drugs. PE2 is a kind cyclic lipopeptide with broad-spectrum antimicrobial activity. Herein, its structure–activity relationship was systematically investigated by employing 4 analogues 23 linear first time. screened 26 27 bearing different fatty acyls at N-termini Tyr residue 9th position superior potency compared to showed equivalent activity PE2. Notably, exhibited...
Antimicrobial peptides (AMPs) have emerged as promising agents to combat the antibiotic resistance crisis due their rapid bactericidal activity and low propensity for drug resistance. However, AMPs face challenges in terms of balancing enhanced antimicrobial efficacy with increased toxicity during modification processes. In this study, de novo d-type β-hairpin are designed. The conformational transformation self-assembling peptide
Background Hyperlipidemia and its complications are among the most harmful of diseases with a worldwide impact, which creates an urgent imperative to find safe effective drugs for treatment. HG is mainly composed two kinds traditional Chinese medicines (TCM), Hong-Qu gypenosides. Previously, ingredients mixture by gypenosides (HG) were widely used purposes lipid-lowering, antiatherosclerosis effects, maintaining cardiovascular health in China. The purpose this study was determine whether...
The emergence of multidrug-resistant bacteria has dramatically increased the lethality, level resistance, and difficulty treatment. In this study, a series new antimicrobial peptides (AMPs) based on β-hairpin structure with template (XY)2RRRF(YX)2-NH2 (X: hydrophobic amino acids; Y: cationic acids) were synthesized; surprisingly, almost all have strong antibacterial activity negligible hemolytic toxicity. Particularly, therapeutic index (TI) values F(RI)2R F(KW)2K reached up to 115.9 70.7,...
ABSTRACT Background: The clinical manifestations of intrahepatic cholangiocarcinoma (ICC) are non-specific, and only a small number patients eligible for surgical resection at the time diagnosis, limiting treatment options. Anticancer peptides (ACPs) exhibit strong inhibitory activity against tumour cell lines, minimal side effects, easily modified optimised, have low production costs. These attributes make ACPs prospect applications. Simultaneously, development patient-derived...
This work aimed to investigate the hepatoprotective effect of total flavonoids from Glycyrrhiza uralensis. The main compounds in licorice (LTF) were isolated uralensis and their content LTF more than 60%. Hepatoprotective effects investigated three kinds hepatic injury mice model induced by high-fat emulsion, Chinese liquor tetrachloromethane. Serum ALT, AST ALP levels MDA, TG, cholesterol, hydroxyproline reduced LTF. Simultaneously, SOD glutathione increased These results suggested that can...
With the aim of tackling increasingly serious antimicrobial resistance and improving clinical potential AMPs, a facile de novo strategy was adopted in this study, series new peptides comprising repeating unit (WRX)n (X represents I, L, F, W, K; n = 2, 3, 4, or 5) amidation at C-terminus were designed. Most newly designed exhibited broad range excellent activities against various bacteria, especially difficult-to-kill multidrug-resistant bacteria isolates. Among (WRK)4 (WRK)5, with 4 5 WRK,...
Nonselective toxicity of antimicrobial peptides (AMPs) needs to be solved urgently for their application. Temporin-PE (T-PE, FLPIVAKLLSGLL-NH2), an AMP extracted from skin secretions frogs, has high and specific activity against Gram-positive bacteria. To improve the performance T-PE, a series T-PE analogues were designed synthesized by glutamic acid full-scan, then key positions replaced with lysine. Finally, E11K4K10, highest therapeutic indicial AMP, was screened out. E11K4K10 not easy...