A5103013972- Immune Response and Inflammation
- Blood disorders and treatments
- Neutropenia and Cancer Infections
- Acute Myeloid Leukemia Research
- Erythrocyte Function and Pathophysiology
- Hematological disorders and diagnostics
- Acute Lymphoblastic Leukemia research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Virus-based gene therapy research
- Lipoproteins and Cardiovascular Health
- Birth, Development, and Health
- Telomeres, Telomerase, and Senescence
- Hemoglobinopathies and Related Disorders
- Glycosylation and Glycoproteins Research
- Genetic Associations and Epidemiology
- Blood properties and coagulation
- Immune cells in cancer
- Genomic variations and chromosomal abnormalities
- Chemokine receptors and signaling
- Multiple Myeloma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Pregnancy and preeclampsia studies
- Inflammatory mediators and NSAID effects
University of Cambridge
2023-2024
Aquinas College
2024
Papworth Hospital
2024
Flinders Medical Centre
1993-2016
Flinders University
1993-2016
University of South Australia
1998
Royal Prince Alfred Hospital
1998
The University of Adelaide
1974-1976
Michell Instruments (France)
1974
Royal Adelaide Hospital
1974
To study the regulation of granulopoiesis, we measured effect endotoxin on peripheral leukocyte counts and colony-stimulating factor (CSF) in serum CF1 mice. The granulocyte level fell from 612 ± 69 (mean S.E.M.) to 147 20 per cubic millimeter within 45 minutes intraperitoneal injection 5 μg Salmonella typhosa endotoxin. In control animals, CSF 0.1 ml stimulated growth 0.56 0.4 vitro myeloid colonies 105 cells. Forty-five after activity had increased 7.7 6.1 cells; two hours it was 29.6 10...
Abstract Background and Aims Low birth weight is a common pregnancy complication, which has been associated with higher risk of cardiometabolic disease in later life. Prior Mendelian randomization (MR) studies exploring this question do not distinguish the mechanistic contributions variants that directly influence through foetal genome (direct effects), vs. influencing indirectly by causing an adverse intrauterine environment (indirect maternal effects). In study, MR was used to assess...
An animal model of a human periodic disease, cyclical neutropenia, was produced in five nine dogs by administration constant daily dose cyclophosphamide so as to cause mild bone-marrow depression. That this would occur predicted computer which granulopoiesis regarded being controlled two feedback loops, one regulating rate production and the other release neutrophils. Cyclical neutropenia does not appear be specific entity, its periodicity, extension possibly that diseases, may due action...
Current guidelines advise against the use of lipid-lowering drugs during pregnancy. This is based only on previous observational evidence demonstrating an association between statin and congenital malformations, which increasingly controversial. In absence clinical trial data, we aimed to drug-target Mendelian randomization model potential impact fetal LDL-lowering, overall through PCSK9 drug targets, malformations. Instrumental variants influencing LDL levels PCSK9-inhibitor targets were...
The effect of oral administration chloramphenicol was studied in normal mice and having residual marrow damage. In the concentration used drug had no detectable on but caused a progressive fall numbers pluripotential stem cells granulocytic progenitor bearing However, taken from such were more sensitive than to vitro action chloramphenicol. results suggest that unrecognized damage can be an aetiological factor failure due idiosyncrasy.
Abstract Previous studies showed that after 5 μg of Salmonella typhosa endotoxin there was an increase in colony stimulating factor temporally related to a fall murine marrow vitro forming cells (CFC). This followed by differentiation along the granulocytic pathway. The present peripheral blood CFC fell approximately 50% at one hour, rose level ten fold control six hours and then returned values 48 hours. There progressive number splenic from 24 72 endotoxin. These data imply migration...
In at least six of 11 normal dogs serial measurement reticulocyte counts showed oscillation with a period approximately 14 days. The phase could be altered by bleeding followed retransfusion. observations suggest that canine erythropoiesis is an example physiological rhythm which has its origin in homeostatic control.
SUMMARY Oscillation of the platelet count was found in 4 11 normal individuals. This finding suggests that production at least some individuals is controlled by a negative feedback circuit containing time delay. type known to be capable stable oscillation. The periods oscillation were between 21 35 days and are similar those cyclical thrombocytopenia. These previous findings suggest many physiological parameters might oscillatory due action homeostasis. Periodic disease could then result...
This study aims to explore characteristics and clinical outcomes of patients with congenital heart disease (CHD) in the European Registry for Patients Mechanical Circulatory Support (EUROMACS).
Summary Consideration of some general features controlled biological systems and examination a particular system, granulo‐poiesis, suggest that feedback control may be responsible for many physiological rhythms the periodic observed in number diseases.
Marrow or blood cells from 35 patients with uncontrolled acute myeloblastic leukemia its varients were cultured in vitro. In 28 of the there was sufficient growth to enable be examined morphologically after 9–12 days. 4 which developed indistinguishable normal granulocytes, but remaining 24 leukemic blasts into qualitatively abnormal showing a variable amount somewhat disorganized differentiation. These results are disagreement previous reports and favor clonal theory nature leukemia.
SUMMARY Two patients with polycythæmia vera were studied in order to determine whether blood‐cell cycles present. Neutrophil and platelet found one a reticulocyte cycle the other. The findings suggest that control of cell production by marrow is partly retained vera. In contrast chronic granulocytic leukæmia, no evidence was for slowed cellular maturation.
Observer error in the assessment of marrow hypocellularity was studied by examining histological sections from 37 mice having normal or reduced cellularity and comparing estimated with a previously measured value. For marrows mild moderately subjective estimate almost valueless both terms accuracy reproducibility. Only severely hypocellular marrows, less than 17% normal, could be recognized as being abnormal some degree
BACKGROUND: Preeclampsia is a leading cause of maternal and perinatal morbidity mortality. However, the current understanding its underlying biological pathways remains limited. METHODS: In this study, we performed cross-platform proteome- transcriptome-wide genetic analysis aimed at evaluating causal relevance >2000 circulating proteins with preeclampsia, supported by data on expression over 15 000 genes across 36 tissues leveraging large-scale preeclampsia association from women...