A5039404161- Management of metastatic bone disease
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Tissue Engineering and Regenerative Medicine
- Congenital Diaphragmatic Hernia Studies
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Lung Cancer Treatments and Mutations
- Medical Imaging and Analysis
University of Michigan
2022-2025
Objectives: To determine if piecemeal separation surgery, in conjunction with smaller treatment volumes utilized spine stereotactic radiation therapy (S-SBRT), increased the risk of adjacent level progression (ALP). Methods: We performed a retrospective analysis prospectively maintained database adult oncologic patients who underwent SBRT to at University Michigan from 2010 2021. compared ALP undergoing had pretreatment surgery those did not. Results: Four hundred and ninety-eight sites were...
As cancer therapies have improved, spinal metastases are increasingly common. Resulting complications a significant impact on patient's quality of life. Optimal methods surveillance and avoidance neurologic deficits understudied. This study compares the clinical course patients who initially presented to emergency department (ED) versus multidisciplinary spine oncology clinic underwent stereotactic body radiation therapy (SBRT) secondary progression/presentation metastatic disease.We...
Abstract Introduction: Predicting response to therapy for each patient’s tumor is critical improving long-term outcomes muscle-invasive bladder cancer (MIBC). Our objective establish ex vivo patient-derived organoid (PDO) models that are representative of patients’ tumors and determine potential efficacy standard-of-care curated experimental therapies. Methods: Tumor material was prospectively collected from consented patients with generate short-term PDO models, which were screened against...
Organs are composed of diverse cell types that change across space and time during development. To interrogate this diversity, we micro-dissected developing human lungs along the proximal-distal axis late pseudoglandular stage generated an integrated analysis single-nucleus sequencing spatial transcriptomics, creating a cellularly-resolved atlas lung. These rich datasets revealed positional niches cellular heterogeneity axis, including identification unique population TP63+ basal cells,...
Spinal metastases can be contained in the bone or have epidural spread. Whether extent of involvement changes tumor response to therapy is unknown. The decision when treat disease progression with focal radiation without surgery vs. systemic debated. present study compared outcomes and local control after stereotactic body (SBRT) between patients spine localized (Bilsky 0) mild spread 1). A retrospective analysis a prospectively maintained database adult oncological who underwent SBRT at...
Abstract Introduction: Bladder cancer (BC) is the most frequent urinary system in US. Neoadjuvant chemotherapy before cystectomy for muscle-invasive BC standard management, though absolute survival benefit small, with many patients progressing during chemotherapy. Identifying therapies a high probability of specific activity against each patient’s tumor remains critical need. Methods: Following informed consent, from undergoing transurethral resection bladder or cystectomy, 1+ gram was...
Abstract As cancer therapies have improved, survival has increased. Spine metastases are becoming more common in the course of oncologic disease. Complications arising from these a significant impact on patient quality life and optimal method to follow patients avoid deficits not yet been adequately studied. The purpose this study was identify characteristics subgroup with metastatic spinal Retrospective analysis oncological ( > 18 years) who underwent stereotactic body radiation...