A5086098583- Herpesvirus Infections and Treatments
- Mosquito-borne diseases and control
- Cytomegalovirus and herpesvirus research
- RNA regulation and disease
- Cellular transport and secretion
- Insect symbiosis and bacterial influences
- Toxin Mechanisms and Immunotoxins
- Vector-Borne Animal Diseases
- Autophagy in Disease and Therapy
- Plant Virus Research Studies
- T-cell and Retrovirus Studies
- Toxoplasma gondii Research Studies
Umeå University
2024-2025
Science for Life Laboratory
2025
Friedrich-Loeffler-Institut
2017-2019
ABSTRACT Flavivirus infection involves extensive remodeling of the endoplasmic reticulum (ER), which is key to both replication viral RNA genome as well assembly and release new virions. However, little known about how proteins host factors cooperatively facilitate such a vast transformation ER, this influences different steps life cycle. In study, we screened for that were enriched in close proximity tick-borne encephalitis virus (TBEV) protein NS4B found top candidates coupled trafficking...
Newly assembled herpesvirus nucleocapsids are translocated from the nucleus to cytosol by a vesicle-mediated process engaging nuclear membranes. This transport is governed conserved egress complex (NEC), consisting of alphaherpesviral pUL34 and pUL31 homologs. The NEC not only required for efficient but also sufficient vesicle formation inner membrane (INM), as well synthetic lipid bilayers. recently solved crystal structures NECs different herpesviruses revealed molecular details this...
Nuclear egress of herpesvirus capsids is mediated by the conserved nuclear complex (NEC), composed membrane-anchored pUL34 and its nucleoplasmic interaction partner, pUL31. The recently solved crystal structures NECs from different herpesviruses show a high structural similarity, with homologs building platform recruiting pUL31 to inner membrane. Both proteins possess central globular fold, while N-terminal portion forms an extension reaching around core pUL34. However, extreme N terminus...
Herpesvirus nucleocapsids leave the nucleus by a vesicle-mediated translocation mediated viral nuclear egress complex (NEC). The NEC is composed of two conserved proteins, designated pUL34 and pUL31 in alphaherpesvirus pseudorabies virus (PrV). It required for efficient sufficient vesicle formation scission from inner membrane (INM). Structure-based mutagenesis identified lysine at position 242 (K242) pUL31, located most distal part NEC, to be crucial nucleocapsid incorporation into budding...
Abstract Flavivirus infection involves extensive remodeling of the endoplasmic reticulum (ER), which is key to both replication viral RNA genome as well assembly and release new virions. Yet, little known about how proteins host factors cooperatively facilitate such a vast transformation ER, this influences different steps life cycle. In study, we screened for that interact with tick-borne encephalitis virus (TBEV) protein NS4B found top candidates were coupled trafficking between ER exit...