A5112531001- Prion Diseases and Protein Misfolding
- Neurological diseases and metabolism
- Alzheimer's disease research and treatments
- Environmental Toxicology and Ecotoxicology
- Animal testing and alternatives
- Pharmacogenetics and Drug Metabolism
- Parasitic infections in humans and animals
- Agricultural and Food Production Studies
- Pharmacological Effects and Assays
- Global Health and Epidemiology
- Maternal and Neonatal Healthcare
- Neurogenesis and neuroplasticity mechanisms
- Parasites and Host Interactions
- Contact Dermatitis and Allergies
- Insect behavior and control techniques
- Genetic Syndromes and Imprinting
- Congenital Anomalies and Fetal Surgery
- Plant and soil sciences
- Plant and animal studies
- Amyotrophic Lateral Sclerosis Research
- Global Maternal and Child Health
- Health and Lifestyle Studies
- Nuclear Receptors and Signaling
- Genetic Neurodegenerative Diseases
Universidad Católica de Oriente
2023
Centro Nacional de Microbiologia
2022
Instituto de Salud Carlos III
2022
Institute for Bioengineering of Catalonia
2016-2020
Biomedical Research Networking Center on Neurodegenerative Diseases
2016-2020
Universitat de Barcelona
2016-2020
Universitat Autònoma de Barcelona
2016
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016
Centro de Investigación Biomédica en Red de Salud Mental
2016
Universidad de Antioquia
2013
The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of β-amyloid. Their interaction is mandatory for neurotoxic effects β-amyloid oligomers. In this study, we aimed explore whether protein participates in spreading α-synuclein. Results demonstrate that Prnp expression not α-synuclein spreading. However, although pathological can take place absence expanded faster PrPC-overexpressing mice. addition, binds strongly on PrPC-expressing cells, suggesting role...
The term 'prion-like' is used to define some misfolded protein species that propagate intercellularly, triggering aggregation in recipient cells. For cell binding, both direct plasma membrane interaction and receptors have been described for particular amyloids. In this respect, emerging evidence demonstrates several β-sheet enriched proteins can bind the cellular prion (PrPC). Among other interactions, physiological relevance of binding between β-amyloid PrPC has a relevant focus numerous...
Reelin is an extracellular glycoprotein that modulates neuronal function and synaptic plasticity in the adult brain. Decreased levels of activity have been postulated as a key factor during neurodegeneration Alzheimer’s disease (AD) aging. Thus, changes full-length fragments revealed cerebrospinal fluid (CSF) post-mortem brains samples AD patients with respect to non-AD patients. However, conflicting studies reported decreased or unchanged compared control (nND) cases CSF samples. In...
Neurocysticercosis (NCC), and cystic echinococcosis (CE) are two neglected diseases caused by cestodes, co-endemic in many areas of the world. Imaging studies serological tests used diagnosis both parasitic diseases, but cross-reactions may confound results latter. The novel multiplex bead-based assay with recombinant antigens has been reported to increases diagnostic accuracy techniques. We set-up an immunoassay based on platform (MBA), using rT24H (against Cysticercus cellulosae, causing...
Objetivo: caracterizar sociodemográfica y clínicamente la mortalidad perinatal neonatal tardía en el municipio de Rionegro entre 2018 2021. Material métodos: estudio cuantitativo, descriptivo transversal que incluyó 67 registros muertes reportadas sistema vigilancia salud pública del municipio. Se incluyeron variables sociodemográficas, antecedentes obstétricos parto, datos clínicos los bebés principales causas muerte. calcularon medidas descriptivas según distribución las cuantitativas...