A5101461191- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Bladder and Urothelial Cancer Treatments
- COVID-19 Impact on Reproduction
- Intensive Care Unit Cognitive Disorders
- Inflammasome and immune disorders
- Biomedical Research and Pathophysiology
- Spaceflight effects on biology
- Folate and B Vitamins Research
- Metabolism and Genetic Disorders
- Immune cells in cancer
- Microbial Community Ecology and Physiology
- Respiratory Support and Mechanisms
- Cancer Immunotherapy and Biomarkers
- Space Exploration and Technology
- SARS-CoV-2 detection and testing
University of California, Irvine
2022-2024
Icahn School of Medicine at Mount Sinai
2022-2024
California State Polytechnic University
2023
Hôpital Paris Saint-Joseph
2022
Sacramento VA Medical Center
2022
Tisch Hospital
2022
University of Virginia Health System
2022
Abstract Background Advancing age is a major risk factor for respiratory viral infections. The infections are often prolonged and difficult to resolve resulting hospitalizations mortality. recent COVID-19 pandemic has highlighted this as elderly subjects have emerged vulnerable populations that display increased susceptibility severity SARS-CoV-2. There an urgent need identify the probable mechanisms underlying protect against future outbreaks of such nature. Innate immunity first line...
Since the start of COVID-19 pandemic, in a short span 3 years, vaccination against SARS-CoV-2 has resulted end pandemic. Patients with inborn errors immunity (IEI) are at an increased risk for infection; however, serious illnesses and mortality, especially primary antibody deficiencies (PADs), have been lower than expected other high-risk groups. This suggests that PAD patients may mount reasonable effective response to vaccine. Several studies published regarding responses, contradictory...
Abstract Mycobacterium bovis Bacillus Calmette-Guerin (BCG) is the primary treatment for non-muscle-invasive bladder cancer (NMIBC), known to stimulate inflammatory cytokines, notably interferon (IFN)-γ. We observed that prolonged IFN-γ exposure fosters adaptive resistance in recurrent tumors, aiding immune evasion and tumor proliferation. identify HLA-E NKG2A, part of a novel NK T cell checkpoint pathway, as key mediators BCG-unresponsive NMIBC. enhances PD-L1 expression with an enrichment...
Whole-genome sequencing can be used to better understand and assess the functional abilities of microorganisms isolated from spacecraft hardware associated surfaces for planetary protection (PP) purposes. We sequenced 191 isolates 6 spaceflight missions with PP requirements identified them using Illumina-based methods matrix-assisted laser desorption ionization-time flight (MALDI-TOF) mass spectrometry.
Abstract Mycobacterium bovis Bacillus Calmette-Guerin (BCG), the first-line treatment for non-muscle invasive bladder cancer (NMIBC), promotes production of inflammatory cytokines, particularly interferon (IFN)-γ. Prolonged inflammation and IFN-γ exposure are known to cause an adaptive immune response, enabling escape proliferation by tumor cells. We investigated HLA-E NKG2A, a novel T NK cell checkpoint pathway, as driver resistance in BCG unresponsive NMIBC. observed ubiquitous all...
Journal of the American Society Nephrology 33(11S):p 692, November 2022. | DOI: 10.1681/ASN.20223311S1692a