A5093283681- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Pluripotent Stem Cells Research
- Renal Transplantation Outcomes and Treatments
- Tracheal and airway disorders
- Tumors and Oncological Cases
- Immune cells in cancer
- Congenital Diaphragmatic Hernia Studies
- Liver physiology and pathology
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
Icahn School of Medicine at Mount Sinai
2023-2024
Abstract The induction of tissue-specific vessels in vitro living tissue systems remains challenging. Here, we directly differentiated human pluripotent stem cells into CD32b + putative liver sinusoidal progenitors (iLSEP) by dictating developmental pathways. By devising an inverted multilayered air-liquid interface (IMALI) culture, hepatic endoderm, septum mesenchyme, arterial and quadruple self-organized to generate sustain hepatocyte-like neighbored divergent endothelial subsets composed...
Abstract Mycobacterium bovis Bacillus Calmette-Guerin (BCG) is the primary treatment for non-muscle-invasive bladder cancer (NMIBC), known to stimulate inflammatory cytokines, notably interferon (IFN)-γ. We observed that prolonged IFN-γ exposure fosters adaptive resistance in recurrent tumors, aiding immune evasion and tumor proliferation. identify HLA-E NKG2A, part of a novel NK T cell checkpoint pathway, as key mediators BCG-unresponsive NMIBC. enhances PD-L1 expression with an enrichment...
Objectives Tracheal transplantation is an ideal option for the reconstruction of long‐segment circumferential tracheal defects. Our group performed first successful vascularized single‐staged in January 2021. Although a rigid biocompatible structure necessary functioning replacement, importance ciliated epithelium, which allows critical mucociliary clearance, now being appreciated. Here, we examined histological changes human transplant from serial endoscopic biopsies. Methods Biopsies...