A5036653777- Mathematical Analysis and Transform Methods
- Neurogenetic and Muscular Disorders Research
- RNA Research and Splicing
- Numerical methods in inverse problems
- RNA regulation and disease
- Amyotrophic Lateral Sclerosis Research
- Hereditary Neurological Disorders
- biodegradable polymer synthesis and properties
- RNA modifications and cancer
- Image and Signal Denoising Methods
- Sparse and Compressive Sensing Techniques
- Quantum Mechanics and Non-Hermitian Physics
- Advanced Mathematical Modeling in Engineering
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Quantum chaos and dynamical systems
- Glycosylation and Glycoproteins Research
- Stability and Controllability of Differential Equations
- Ubiquitin and proteasome pathways
- HER2/EGFR in Cancer Research
- RNA Interference and Gene Delivery
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Analytic and geometric function theory
- Multiple Myeloma Research and Treatments
Centro di Riferimento Oncologico
2023-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2025
International Centre for Genetic Engineering and Biotechnology
2019-2024
Multiple myeloma (MM) is an incurable hematological disease characterized by the uncontrolled growth of plasma cells primarily in bone marrow. Although its treatment consists administration combined therapy regimens mainly based on immunomodulators and proteosome inhibitors, MM remains incurable, most patients suffer from relapsed/refractory with poor prognosis survival. The robust results achieved immunotherapy targeting MM-associated antigens CD38 CD319 (also known as SLAMF7) have drawn...
Introduction The functionalization of nanoparticles (NPs) with an antiCD19 targeting mechanism represents a promising approach for the selective delivery drugs and nucleic acids into normal tumor B cells. This strategy has advantage minimizing off-target effects by restricting gene to desired cell population. However, nanoplatform must guarantee both local production protein safety treatment allow effective therapy reduced systemic toxicity. Methods In order ensure acids, we developed...
In this paper we prove an optimal estimate for the norm of wavelet localization operators with Cauchy and weight functions that satisfy two constraints on different Lebesgue norms. We multiple regimes arise according to ratio these norms: if belongs a fixed interval (which depends exponents) then both are active, while outside one constraint is inactive. Furthermore, characterize functions.
Spinal Muscular Atrophy results from loss-of-function mutations in SMN1 but correcting aberrant splicing of SMN2 offers hope a cure. However, current splice therapy requires repeated infusions and is expensive. We previously rescued SMA mice by promoting the inclusion defective exon with germline expression Exon-Specific U1 snRNAs (ExspeU1). Here we tested viral delivery ExspeU1s encoded adeno-associated virus AAV9. Strikingly increased 7 SMN protein levels phenotype mild severe mice. In...
The elucidation of aberrant splicing mechanisms, frequently associated with disease has led to the development RNA therapeutics based on U1snRNA, which is involved in 5′ splice site (5′ss) recognition. Studies cellular models have demonstrated that engineered U1snRNAs can rescue different mutation types. However, assessment their correction potential vivo limited by scarcity animal targetable defects. Here, we challenged U1snRNA FAH5961SB mouse model hepatic fumarylacetoacetate hydrolase...
Aging progressively modifies the physiological balance of organism increasing susceptibility to both genetic and sporadic neurodegenerative diseases. These changes include epigenetic chromatin remodeling events that may modify transcription levels disease-causing genes affecting neuronal survival. However, how these interconnect is not well understood. Here, we found Su(var)3-9 causes increased methylation histone H3K9 in promoter region TDP-43, most frequently altered factor amyotrophic...
In this paper we study the Hilbert-Schmidt norm of time-frequency localization operators $L_{\Omega} \colon L^2(\mathbb{R}^d) \rightarrow L^2(\mathbb{R}^d)$, with Gaussian window, associated a subset $\Omega\subset\mathbb{R}^{2d}$ finite measure. We prove, in particular, that $L_\Omega$ is maximized, among all subsets $\Omega$ given measure, when ball and there are no other extremizers. Actually, main result quantitative version estimate, sharp exponent. A similar problem addressed for...
Familial Dysautonomia (FD) is a rare disease caused by ELP1 exon 20 skipping. Here we clarify the role of RNA Polymerase II (RNAPII) and chromatin on this splicing event. A slow RNAPII mutant chromatin-modifying chemicals that reduce rate elongation induce skipping whereas create more relaxed inclusion. In brain mouse transgenic for human FD-ELP1 observed gene an age-dependent decrease in density profile was most pronounced alternative exon, robust increase repressive marks H3K27me3 H3K9me3...
Lieb and Solovej proved that, for the symmetric $SU(N)$ representations, corresponding Wehrl-type entropy is minimized by coherent states. However, uniqueness of minimizers remained an open problem when $N\geq 3$. In this note we complete proof Wehrl conjecture such showing that states are, in fact, only minimizers. We also provide application to maximum concentration holomorphic polynomials.
Abstract Aging progressively modifies the physiological balance of organism increasing susceptibility to both genetic and sporadic neurodegenerative diseases. These changes include epigenetic chromatin remodeling events that may modify gene transcription. However, how aging interconnects with disease-causing genes is not well known. Here, we found Su(var)3-9 causes increased methylation histone H3K9 in promoter region TDP-43, most frequently altered factor amyotrophic lateral sclerosis...
In this paper we provide an optimal estimate for the operator norm of time-frequency localization operators with Gaussian window $L_{F,\varphi} : L^2(\mathbb{R}^d) \rightarrow L^2(\mathbb{R}^d)$, under assumption that $F \in L^p(\mathbb{R}^{2d}) \cap L^q(\mathbb{R}^{2d})$ some $p$ and $q$ in $(1,+\infty)$. We are also able to characterize weight functions, whose shape turns out depend on ratio $\|F\|_q / \|F\|_p$. Roughly speaking, if is "sufficiently large" or small" functions certain...