A5039215556- Radiopharmaceutical Chemistry and Applications
- Bone health and treatments
- Prostate Cancer Treatment and Research
- Growth Hormone and Insulin-like Growth Factors
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Cancer Research and Treatments
- MRI in cancer diagnosis
- Mesenchymal stem cell research
- FOXO transcription factor regulation
- Electrospun Nanofibers in Biomedical Applications
- Retinal Diseases and Treatments
- Hydrogels: synthesis, properties, applications
- Ovarian cancer diagnosis and treatment
- Calcium Carbonate Crystallization and Inhibition
- Muscle Physiology and Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Retinal Development and Disorders
- Cancer, Lipids, and Metabolism
- Connective Tissue Growth Factor Research
- Retinoids in leukemia and cellular processes
The University of Queensland
2024
Prostate Cancer Foundation of Australia
2016-2021
Translational Research Institute
2014-2021
Queensland University of Technology
2013-2021
Australian Regenerative Medicine Institute
2019-2021
Griffith University
2021
National Institute of Biomedical Innovation, Health and Nutrition
2014
In vitro engineering of a bone metastases model allows us to study the effects antiandrogens in advanced prostate cancer.
While stromal interactions are essential in cancer adaptation to hormonal therapies, the effects of bone stroma and androgen deprivation on progression poorly understood. Here, we tissue-engineered validated an vitro microtissue model osteoblastic metastases, used it study this microenvironment. The was established by culturing primary human osteoprogenitor cells melt electrowritten polymer scaffolds, leading a mineralized osteoblast-derived containing, 3D setting, viable cells, osteocytic...
Synthetic hydrogels selectively decorated with cell adhesion motifs are rapidly emerging as promising substrates for 3D culture. When cells grown in they experience potentially more physiologically relevant cell–cell interactions and physical cues compared traditional 2D culture on stiff surfaces. A newly developed polymer based poly(2-oxazoline)s has been used the first time to control attachment of fibroblast is discussed here its potential use particular focus cancer toward ultimate aim...
Abstract Various in vitro culture systems have been used to investigate the pathogenesis of age‐related macular degeneration (AMD). However, many still rely on oversimplified monolayer models. AMD is a complex disease, associated with pathological changes multiple structural components such as Bruch's membrane, retinal pigment epithelium (RPE), and choroidal endothelial cells. This study aims construct novel 3D coculture model using polycaprolactone (PCL)‐gelatin electrospun scaffold, human...
Androgen deprivation therapy (ADT) is the standard treatment for advanced prostate cancer (PCa), yet many patients relapse with lethal metastatic disease. With this loss of androgens, increased cell plasticity has been observed as an adaptive response to ADT. This includes gain invasive and migratory capabilities, which may contribute PCa metastasis. Hyperinsulinemia, develops a side-effect ADT, associated tumor aggressiveness faster failure. We investigated direct effects insulin in cells...
Advanced prostate cancer (PCa) is known for its high prevalence to metastasize bone, at which point it considered incurable. Despite significant effort, there no animal model capable of recapitulating the complexity PCa bone metastasis. The humanized mouse metastasis used in this study aims provide a platform assessment new drugs by human-human cell interactions relevant disease development and progression. tissue-engineered construct (hTEBC) was created within NOD-scid IL2rgnull (NSG) mice...
Abstract Insulin-like growth factor (IGF)-I binds to the ECM protein vitronectin (VN) through IGF binding proteins (IGFBPs) enhance proliferation and migration of skin keratinocytes fibroblasts. Although evidence exists for role individual components complex (IGF-I, IGFBP-3 VN), cellular functions stimulated by these together as a remains un-investigated in melanoma cells. We report here that IGF-I:IGFBP-3:VN trimeric stimulates dose-dependent increase WM35 Sk-MEL28 In 3D Matrigel ™ hydrogel...
Abstract Diffusion-weighted magnetic resonance imaging (DW-MRI) was used to evaluate the effects of single-agent and combination treatment regimens in a spheroid-based animal model ovarian cancer. Ovarian tumour xenografts grown non-obese diabetic/severe-combined-immunodeficiency (NOD/SCID) mice were treated with carboplatin or paclitaxel, carboplatin/paclitaxel chemotherapy regimens. After 4 weeks treatment, tumours extracted underwent DW-MRI, mechanical testing, immunohistochemical gene...
Pearls are highly prized biomineralized gemstones produced by molluscs. The appearance and mineralogy of cultured pearls can vary markedly, greatly affecting their commercial value. To begin to understand the role pearl sacs—organs that form in host oysters from explanted mantle tissues surround synthesize pearls—we undertook transcriptomic analyses identify genes differentially expressed sacs producing with different surface structural characteristics. Our results indicate gene expression...
The development of safe and efficient delivery systems for targeted controlled release therapeutic agents has become a major focus in pharmacotherapy. colon is one organ that serves as an optimal site the absorption protein peptide drugs, offering significant potential both localized systemic therapies. However, effective drug challenged by need to protect these drugs from premature maintain their stability across varying pH levels gastrointestinal tract. In this study, we introduce, first...
Abstract We provide proof-of-concept evidence for a new class of therapeutics that target growth factor:extracellular matrix (GF:ECM) interactions the management breast cancer. Insulin-like factor-I (IGF-I) forms multiprotein complexes with IGF-binding proteins (IGFBP) and ECM protein vitronectin (VN), stimulates survival, migration invasion cancer cells. For first time we physical IGFBP-3:VN in patient tissues; these were predominantly localized to tumor cell clusters stroma surrounding...
Event Abstract Back to An advanced bioengineered 3D model mimicking prostate cancer-induced bone metastasis microenvironment Ali Shokoohmand1, 2, Nathalie Bock1, Judith A. Clements1, 2 and Dietmar W. Hutmacher1, 3, 4 1 Queensland University of Technology (QUT), Institute Health Biomedical Innovation, Australia QUT, Australian Prostate Cancer Research Centre – Queensland, 3 Technical Munich (TUM), for Advanced Study, Germany Georgia Technology, George W Woodruff School Mechanical Engineering,...
Event Abstract Back to A bioengineered 3D approach mimic the tumor-stroma microenvironment of ovarian cancer Ali Shokoohmand1, 2, Daniela Loessner1, Boris M. Holzapfel1, Ferdinand Wagner1, Jeremy Baldwin1, Anja Rockstroh2, Viktor Magdolen3, Judith A. Clements1, 2 and Dietmar W. Hutmacher1, 4, 5 1 Queensland University Technology (QUT), Institute Health Biomedical Innovation, Australia QUT, Australian Prostate Cancer Research Centre–Queensland, 3 Technical Munich (TUM), Clinical Unit,...
Event Abstract Back to A novel three-dimensional trilayer for studying early changes in age-related macular degeneration Ali Shokoohmand1, 2, June E. Jeon1, Christina Theodoropoulos1, Dietmar W. Hutmacher1, 3, 4 and Beatrix Feigl1, 5 1 Queensland University of Technology (QUT), Institute Health Biomedical Innovation, Australia 2 QUT, Australian Prostate Cancer Research Centre – Queensland, 3 Technical Munich (TUM), Advanced Study, Germany Georgia Technology, George W Woodruff School...
<p>Supplementary Fig. S1: Tissue microarray VN:IGFBP-3 PLA immunoreactivity and patient information; Supplementary S2: VN peptide array amino acid sequence S3: IGFBP-3 S4: of HMLER-FOXC2 primary tumour xenografts; S5: Single channel images in situ PLA; S6: IGF-II-induced cell signalling MCF-7 breast cancer cells; S7: Breast migration measured using the xCELLigence assay; S8: Optimisation ligand binding to its subsequent immunodetection; S9: Identification sites on information from...