A5012596137- Bone Metabolism and Diseases
- Advanced Computational Techniques and Applications
- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- Rough Sets and Fuzzy Logic
- Urological Disorders and Treatments
- Extenics and Innovation Methods
- Acupuncture Treatment Research Studies
- Medical Imaging and Analysis
- Cell Adhesion Molecules Research
- Bone fractures and treatments
- NF-κB Signaling Pathways
- Traditional Chinese Medicine Studies
- Protease and Inhibitor Mechanisms
- Microtubule and mitosis dynamics
- Orthopaedic implants and arthroplasty
- Spine and Intervertebral Disc Pathology
- Medical Research and Treatments
- Railway Systems and Energy Efficiency
- Biofield Effects and Biophysics
- Plant responses to water stress
- Hippo pathway signaling and YAP/TAZ
- Paraquat toxicity studies and treatments
- Anatomy and Medical Technology
- Advanced Clustering Algorithms Research
China Medical University
2008-2024
Sun Yat-sen University
2023
Sichuan Agricultural University
2020
First Hospital of China Medical University
2011-2019
Guangdong Provincial Hospital of Traditional Chinese Medicine
2017
Jinan University
2011-2014
Health Commission of Jilin Province
2012
Second Affiliated Hospital of Guangzhou Medical University
2006-2011
Guangzhou Medical University
2006-2011
Tongji University
2010
It is known that prolonged glucocorticoid (GC) treatment results in osteoporosis. This study aimed to evaluate the protective effects of curcumin on bones rats with dexamethasone (DXM)-induced In present study, were administered DXM for 60 days induce osteoporosis, and they then treated (100 mg/kg/day) a further days. H&E staining was used observe pathological changes femurs. Serum osteocalcin levels collagen-type I fragments (CTX) examined as bone metabolism markers. The revealed attenuated...
Summary Curcumin, an active component of the rhizomes Curcumin longa L ., possesses broad anti‐inflammation and anti‐cancer properties. was previously reported to be capable protecting ovariectomized rats against osteoporosis. However, effect curcumin on glucocorticoid‐induced osteoporosis ( GIO ) is not yet clear. The present study investigated effects dexamethasone (Dex)‐induced in vivo Dex‐induced osteoblast apoptosis vitro . rat model induced by subcutaneous injection Dex for 60 days...
Glucocorticoid (GC)-induced osteoporosis (GIO) is one of the most common secondary and iatrogenic forms osteoporosis. GCs are widely used in clinical therapy play a key role normal regulation bone remodeling. However, prolonged high-dose administration results occurrence osteoporosis, which partially due to dysfunction apoptosis osteoblasts osteocytes. The aim present study was investigate effects gastrodin, natural bioactive compound isolated from traditional Chinese herbal agent Gastrodia...
Breast cancer is a threat to the health of women, and metastasis breast cells plays an important role in deterioration cancer. MicroRNAs play critical tumorigenesis development MicroRNA-148a (miR-148a) associated with growth tumor cells. In present study, we investigated miR-148a migration as well underlying mechanism. MiR-148a was found inhibit proliferation To further explore mechanism through which its antitumor role, matrix metalloproteinase-13 (MMP-13) identified target by western blot...
// DongZhi Cen 1, * , Li Xu 2, Ningna Zhiguang Chen Lu Wang Shuqin Zhou Biao Chun ling Liu 3 Zaiyi Tingting Luo 4 1 Department of Radiation Oncology and Nuclear Medicine, The Third Affiliated Hospital Guangzhou Medical University, Guangzhou, 510150, Guangdong Province, People’s Republic China 2 Provincial Traditional Chinese Medicine Hospital, Province 510120, P.R. Radiology, General Academy Sciences, 510080, People's Ultrasound, Shenzhen, Shenzhen 518112, These authors contributed...
Puerarin is an active component of Pueraria lobata, which a commonly used Chinese herbal medicine for the treatment osteoporosis. The present study aimed to evaluate osteoprotective effect puerarin on glucocorticoid (GC)‑induced apoptosis osteoblasts in vitro. effects dexamethasone (DEX)‑induced cell were assessed using enzyme‑linked immunosorbent assay and terminal deoxynucleotidyl transferase dUTP nick‑end labeling assay, found that viability hFOB1.19 cells was significantly increased...
Bone remodeling is a vital physiological process of healthy bone tissue in humans. It characterized by the formation osteoblasts and its resorption osteoclasts, resorbed osteoclasts replaced through differentiation activity osteoblasts. Imbalances this lead to pathological conditions, including osteoporosis. Intermedin (IMD) as newly discovered peptide calcitonin (CT) family peptides, which shares similar functions with CT, gene‑related amylin resorption. However, mechanism underlying effect...
Stray current corrosion (SCC) is one of the most severe forms electrochemical corrosion. In paper, mechanism and character stray from DC electric traction systems its influence upon buried pipe were briefly introduced. The testing methods equipments reviewed. A new system for monitoring current, based virtual instrument, was put forward. proposed has some advantages such as real-time display, frequency control, automatic data storage. pipe-soil potentials a gas pipeline, located in...
In order to provide scientific and empirical evidence for the clinical application of polyaxial self-locking anatomical plate, 80 human tibias from healthy adults were scanned by spiral CT their three-dimensional images reconstructed using surface shaded display (SSD) method. Firstly, based on geometric data distal tibia, a plate tibia was designed constructed. Biomechanical tests then performed applying axial loading, 4-point bending, torsion loading fracture fixation models fresh cadaver...
Substantial advances have been made in understanding the role of partial PDZ and LIM domain family's proteins skeletal-related diseases. Yet, little is known about effect Domain 1 (Pdlim1) on osteogenesis fracture repair. This study aimed to investigate whether direct gene delivery using an adenovirus vector carrying Pdlim1 (Ad-oePdlim1) or encoding shRNA-Pdlim1 (Ad-shPdlim1) could affect osteogenic activity preosteoblastic MC3T3-E1 cells vitro, influence healing mice vivo. We found that...
Abstract Background Centromere protein F (CENPF) is a key component of the kinetochore complex involved in mitosis, cell differentiation and cellular response to stresses. However, alteration CENPF endoplasmic reticulum (ER) stress has not been well described. In present study, we investigate regulation ER stress. Methods Quantitative real-time polymerase chain reaction western blotting were used determine expression under Luciferase activity analysis was performed promoter regions...
Abstract Osteogenic differentiation is important for fracture healing. Microfibrial‐associated glycoprotein 2 (MAGP2) found to function as a proangiogenic regulator in bone formation; however, its role osteogenic during repair not clear. Here, mouse model of critical‐sized femur was constructed, and the adenovirus expressing MAGP2 delivered into site. Mice with overexpression exhibited increased mineral density volume fraction (BV/TV) at Day 14 postfracture. Within 7 days postfracture,...