Y Li

ORCID: 0009-0005-9694-486X
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About
Contact & Profiles
Research Areas
  • Marine and coastal ecosystems
  • Ocean Acidification Effects and Responses
  • Neuropeptides and Animal Physiology
  • Algal biology and biofuel production
  • Receptor Mechanisms and Signaling
  • RNA modifications and cancer
  • MicroRNA in disease regulation
  • Inflammatory mediators and NSAID effects
  • Marine Biology and Ecology Research
  • Protein Tyrosine Phosphatases

Xiamen University
2014-2024

MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 515:73-81 (2014) - DOI: https://doi.org/10.3354/meps11026 Physiological and biochemical responses of diatoms projected ocean changes Juntian Xu1,2, Kunshan Gao1,*, Yahe Li1, David A. Hutchins3 1State Key Laboratory Environmental Science, Xiamen University (Xiang-An campus, ZhouLongQuan A1-211), Xiamen, Fujian...

10.3354/meps11026 article EN Marine Ecology Progress Series 2014-09-15

Abstract Tyrosine phosphatase protein Shp2 is a potential therapeutic target for obesity. However, the mechanism of during adipogenesis not fully understood. The present study investigated role in terminal differentiation preadipocytes. results showed that suppressed adipocyte 3T3-L1 cells; overexpression reduced lipid droplet production cells, whereas knockdown increased cells. Furthermore, inhibition activity also enhanced differentiation. Interestingly, expression was specifically...

10.1038/cddiscovery.2016.51 article EN cc-by Cell Death Discovery 2016-07-04

Prostaglandin D2 receptor 2 (DP2) is an important anti-inflammatory and antiallergic drug target. While inactive DP2 structures are known, its activation mechanisms biased signaling remain unclear. Here, we report cryo-EM of apo DP2–Gi complex, a complex bound to the endogenous ligand D (PGD ), indomethacin, arrestin-biased ligand, at resolutions 2.5 Å, 2.8Å, 2.3 respectively. These reveal distinct binding pose PGD indomethacin provide key insights into transducer coupling. Combining...

10.1073/pnas.2403304121 article EN cc-by-nc-nd Proceedings of the National Academy of Sciences 2024-12-12

Abstract. Ocean Acidification (OA) is known to affect various aspects of the physiological performance diatoms, but there little information on underlining molecular mechanisms involved. Here, we show that in model diatom Phaeodactylum tricornutum expression genes related light harvesting, carbon acquisition and carboxylation, nitrite assimilation ATP synthesis are modulated by OA. Growth photosynthetic fixation were enhanced elevated CO2 (1000 μatm) under both constant indoor fluctuating...

10.5194/bgd-12-15809-2015 article EN cc-by 2015-09-24
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