A5112875926- Intracranial Aneurysms: Treatment and Complications
- Cervical and Thoracic Myelopathy
- Cerebrovascular and Carotid Artery Diseases
- Spine and Intervertebral Disc Pathology
- Vascular Malformations Diagnosis and Treatment
- Chemical Synthesis and Analysis
- Intracerebral and Subarachnoid Hemorrhage Research
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Metastasis and carcinoma case studies
- Spinal Fractures and Fixation Techniques
- Esophageal and GI Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Gastrointestinal Tumor Research and Treatment
- Beetle Biology and Toxicology Studies
- Computer Graphics and Visualization Techniques
- Phytochemical compounds biological activities
- Gastroesophageal reflux and treatments
- Photonic Crystals and Applications
- Research on Leishmaniasis Studies
- Cerebral Venous Sinus Thrombosis
- Peptidase Inhibition and Analysis
- Synthesis and Reactivity of Heterocycles
- Abdominal Surgery and Complications
Osaka Red Cross Hospital
2023-2025
National Cerebral and Cardiovascular Center
2019-2024
Kyoto University
2002-2024
Tokyo University of Science
2007-2024
Japan Agency for Medical Research and Development
2021-2024
Tokyo Women's Medical University
2022
Tokyo Women's Medical University Yachiyo Medical Center
2022
Saitama International Medical Center
2022
Saitama Medical University
2022
Jikei University School of Medicine
2022
Results of C4-C7 laminoplasty with C3 laminectomy and C3-C7 were compared.To clarify prospectively whether the modified preserving semispinalis cervicis inserted into C2 could reduce axial symptoms compared conventional reattaching muscle to C2.Intraoperative damage is relevant development after laminoplasty. In laminoplasty, however, it difficult preserve insertion while opening lamina.The 40 patients (Group A) those 16 B) The cross-sectional areas cervical posterior muscles measured on...
Optically active α,β-diamino acids are prepared under asymmetric phase-transfer reaction conditions from a glycine Schiff base and N-protected imines with tartrate-derived diammonium salt (TaDiAS) as the catalyst (see scheme; Boc=tert-butoxycarbonyl). Chemoselective deprotection of N atoms allows straightforward transformations acid products to be carried out.
We describe the development of a general catalytic asymmetric Michael reaction acyclic beta-keto esters to cyclic enones, in which induction occurs at beta-position acceptors. Among various catalyst systems examined, newly developed La-NR-linked-BINOL complexes (R = H or Me) afforded best results terms reactivity and selectivity. In general, NMe ligand 2 was suitable for combination small enones esters, NH 1 bulkier substrates (steric tuning catalyst). Using La-NMe-linked-BINOL complex,...
Introduction During carotid artery stenting (CAS), safe navigation of the guiding catheter (GC) is essential for success procedures. However, in cases where stenosis or floating thrombi are located common (CCA), especially proximal lesions, advancing GC without touching lesions often difficult. We describe a preliminary experience “no-touch” technique navigating to CCA using an inner with specifically designed shape and stiffness optimized overcome tortuous anatomy. Methods retrospectively...
Abstract Background When inserting central venous catheters, inadvertent injury of major vessels is a rare yet critical complication. Direct surgery sometimes overly invasive. This report describes subclavian artery caused by cannulation dialysis catheter, successfully treated with covered stent. Case Presentation An 82‐year‐old woman acute renal failure due to sepsis required emergency dialysis. During the insertion 12‐Fr catheter into right jugular vein, pulsatile reflux was noted....
BACKGROUND It is important to differentiate arachnoid cysts from endodermal in the posterior cranial fossa because they require different surgical treatments. Arachnoid generally fenestration. Meanwhile, cysts, complete cyst resection preferred prevent recurrence. Despite use of MRI and intraoperative findings, misdiagnosis can occur. Herein, authors report a retroclival that was initially suspected be an based on pre- findings but pathologically diagnosed as postoperatively. OBSERVATIONS A...
In adult syringomyelia associated with Chiari I malformation, the spinal deformity, configuration of cerebellar tonsillar descent, syrinx, and clinical evaluation before after surgery were investigated.To investigate characteristics scoliosis in malformation.In previous studies, pediatric have been reported.In this study, 42 patients treated. All 20 years age or older. They divided into three groups: Group 1 comprising those without scoliosis, 2 composed 10 degrees more but less than...
Optisch aktive α,β-Diaminosäuren konnten in einer asymmetrischen Phasentransferreaktion aus Glycin-Schiff-Base und N-geschützten Iminen mit einem von Tartrat abgeleiteten Diammoniumsalz (TaDiAS) als Phasentransferkatalysator hergestellt werden (siehe Schema; Boc=tert-Butoxycarbonyl). Die chemoselektive Entschützung der N-Atome ermöglicht einfach weitere Umsetzungen α,β-Diaminosäuren.
AGS62P1 is an antibody drug conjugate (ADC) composed of a human IgG1κ monoclonal against FLT3 (FMS-like tyrosine kinase 3) with p-acetyl phenylalanine (pAF) residue inserted at position 124 each heavy chain linked to the proprietary microtubule disrupting agent AGL-0182-30 via alkoxyamine linker that forms oxime upon conjugation antibody. currently in Phase I clinical trials for acute myelogenous leukemia (AML). The identified primary metabolite oxime-linked ADC presented first time....
Ossification of the posterior longitudinal ligament spine (OPLL) is characterized by ectopic bone formation in spinal ligaments, and mechanical stress has been suggested to play an important role progression OPLL. To identify genes that participate OPLL, differential display reverse transcription-polymerase chain reaction (RT-PCR) method was used. A 283-base pair cDNA fragment corresponding prostaglandin I<sub>2</sub> (PGI<sub>2</sub>) synthase highly expressed OPLL cells compared with...
The radical and superoxide scavenging activities of oxidized matairesinols were examined. It could be assumed that the free benzylic position was important for higher activity. different level activity observed between 7′-oxomatairesinol (Mat 2) 7-oxomatairesinol 3). 8-hydroxymatairesinol lower than matairesinol 1). also demonstrated first time. is pKa value phenol in affected this
Abstract Subarachnoid hemorrhage being the rupture of intracranial aneurysm (IA) as a major cause has quite poor prognosis, despite modern technical advances. Thereby, mechanisms underlying lesions should be clarified. Recently, we and others have clarified formation vasa vasorum in IA presumably for inflammatory cells to infiltrate potential histopathological alternation leading rupture. In present study, origin arteries located at brain surface using 3D-immunohistochemistry with tissue...
In the research on application of an optical modulator used for information communication, materials having a large Pockels effect, refractive index change proportional to electric-field, are required. It is known that interfacial water surface transparent oxide electrodes has giant coefficient, which order magnitude larger than solid crystals practically used. important know coefficient not only surface, but also metal understand mechanism effect water. However, method yet been established...
Abstract Growing evidence has suggested that inflammatory responses promote the progression of saccular intracranial aneurysms (IAs). However, a biomarker predicting yet to be established. This study aimed identify novel molecules upregulated during using previously established rat aneurysm model. In this model, are induced at surgically created common carotid artery (CCA) bifurcation. Based on sequential morphological data, observation periods after surgical manipulations were defined as...
Age-related changes in proteoglycans of human ligamentum flavum were studied using specimens obtained from patients divided into four age groups. The pratenglycans ware purified by ion-exchange and gel-filtration chromatography. A low-molecular-weight proteoglycan with the same molecular size was present all each Conversely, high-molecular-weight increased advancing age. Properties sugar chains, glycosaminoglycans, these cellulose acetate membrane electrophoresis chondroitinase digestion, It...
OBJECTIVE Growing intracranial aneurysms (IAs) are prone to rupture. Previous cross-sectional studies using postrupture morphology have shown the morphological or hemodynamic features related IA Yet, which differences of prerupture status can predict growth and rupture smaller IAs remains unknown. The purpose this longitudinal study was investigate effects environment on at middle cerebral artery (MCA) bifurcations during follow-up period. METHODS One hundred two patients with MCA M1–2...
Gastric neuroendocrine carcinomas are rare and have a poor prognosis, the diagnostic criteria for this disease recently changed. We herein report case of sporadic gastric carcinoma. A 75-year-old man was referred to our hospital with epigastric pain. Endoscopic examination revealed localized ulcerative lesion (diameter, 4 cm) at upper stomach. The diagnosis on biopsy Total gastrectomy D2 lymphadenectomy, splenectomy, cholecystectomy performed. Pathologically, tumor infiltrated subserosal...