A5004509093- Glaucoma and retinal disorders
- PARP inhibition in cancer therapy
- Chemotherapy-induced cardiotoxicity and mitigation
- Lung Cancer Treatments and Mutations
- Corneal Surgery and Treatments
- Childhood Cancer Survivors' Quality of Life
- Cancer Treatment and Pharmacology
- Lung Cancer Research Studies
University of Alabama at Birmingham
2023-2025
University of Illinois Chicago
1998
BACKGROUND: Anthracyclines induce cardiotoxicity via DNA double-strand breaks and reactive oxygen species formation, resulting in cardiomyocyte dysfunction. The role of damage response/repair (DDR) genes anthracycline-induced cardiomyopathy remains unstudied. METHODS: We conducted a gene-based pathway-based analysis to examine the main effect gene-anthracycline interaction between DDR cardiomyopathy. A discovery performed with matched case-control set anthracycline-exposed non-Hispanic White...
The trabecular meshwork (TM) is a specialized eye tissue essential for regulation of the aqueous humor outflow and control intraocular pressure. Disturbances TM cells may lead to elevated pressure glaucoma. This study assessed dexamethasone effects on levels extracellular matrix proteins their integrin receptors in bovine cells. Instillation glucocorticoids such as known result ocular hypertension. histologic changes induced resemble those seen Examination glucocorticoid therefore provide...
Background Anthracycline‐induced cardiomyopathy is a leading cause of premature death in childhood cancer survivors, presenting need to understand the underlying pathogenesis. We sought examine differential blood‐based mRNA expression profiles anthracycline‐exposed survivors with and without cardiomyopathy. Methods Results designed matched case‐control study (Children's Oncology Group‐ALTE03N1) sequencing on total RNA from peripheral blood 40 (cases) 64 (controls). DESeq2 identified...