Artemisia annua L. has gained increasing attention for its anticancer activity. However, beside artemisinin, less is known about the possible bioactive ingredients of and respective herbal preparations. We hypothesized that, in addition to preparations might contain multiple with potential activity.MDA-MB-231 triple negative human breast cancer (TNBC) cells along other treatment resistant, metastatic cell lines were used investigate vitro vivo efficacy an extract marketed as a preparation,...

Pentacyclic triterpenic acids from oleogum resins of Boswellia species are considerable therapeutic interest. Yet, their pharmaceutical development is hampered by uncertainties regarding botanical identification and the complexity acid mixtures. Here, a highly sensitive, selective, accurate method for simultaneous quantification eight boswellic lupeolic high-performance liquid chromatography with tandem mass spectrometry detection (HPLC-MS/MS) was developed. The applied to comparative...

For centuries, frankincense extracts have been commonly used in traditional medicine, and more recently, complementary medicine. Therefore, constituents such as boswellic lupeolic acids are of considerable therapeutic interest. Sixteen nutraceuticals were characterized by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS), revealing major differences acid compositions total contents, which varied from 0.4% to 35.7%. Frankincense significantly inhibited the...

This paper describes the evaluation of human-robot-interaction (HRI) related to future use a humanoid robotic system as interface in intelligent home environments. The core motivation was enhance user interaction between smart systems and senior users by introducing humanoid, mobile socially assistive robot interface. To what extend older accept autonomous is central research topic covered this paper. evaluate question performed together with 16 people within "Living Lab Schwechat" Austria...

Social play is a key factor in children's positive development. Children with different interactional styles, such as neurodivergent children, face challenges to create opportunities for playing peers practice and acquire complex social skills, putting their emotional wellbeing at risk. We report on the design of technologies that aim scaffold support, non-normative ways, co-located heterogeneous, neurodiverse groups children aged 6 8. In three case studies we describe participatory...

Enabled by web and mobile technologies, there has been an explosion of interest in the sharing economy peer-to-peer exchange, with much high profile attention given to monetised exchanges such as AirBnB Uber. However are also many other initiatives, time banking, that focus on smaller, more local communities do not involve monetisation exchanges. While is a growing body literature elaborating participation motivation services well analysing organisers’ roles, little discussed about work...

This paper disseminates work from the European Give&Take project, which aims at co-designing service sharing among senior citizens based on a mobile and distributed platform. With this project as frame, authors' addresses methodological considerations of participation in co-design for ageing. Based notions design culture, communities everyday practice situated elderliness authors present accounts two countries, discuss issues related to mobilizing they have manifested themselves...

OBJECTIVE: In western countries, the number of people who have dementia rises continuously. Approximately 80% live at home, supported by their relatives, but burden these informal caregivers is high. We developed Android application DEA to support them.

Children and designers have divergent, sometimes contradictory notions of what "design" means. Unrestricted by the lens adulthood shackles formal creative education, children ask unexpected questions, draw unlikely conclusions, a different experience creation. How do we recognise, address adapt to these differences creativity, how can successfully from them in our design process? In this paper, describe tensions participatory (PD) sessions conducted, focusing on needs strengths their role as...

Digital tools and services are becoming the standard for delivery of health care, especially hastened by restrictions needs during COVID-19 pandemic. While early experiences with telemedicine have been a foundation modern day digital tool development, use co-creation, user meta dialogue, follow up often short few. This represents powerful potential designing upcoming multi-level platform. requires, however, equity in literacy, which is not case. Rather than seeing effect or impact as outcome...

Purpose Problems with handwriting are a common referral to occupational therapy in children and often associated inadequate pen grip tip pressure. Technologies providing immediate feedback on applied forces currently not available. Therefore, the aim was identify user's perspectives optimal functionality of pressure-sensitive an integrated system.Methods To ensure that product meets requirements users, user needs paediatric therapists, elementary or special education teachers were collected...

Frankincense is an oleogum resin from Boswellia trees of the Burseraceae family. The contains 15–20 % triterpenic acids, including therapeutically active boswellic acids [1]. Extracts resins obtained serrata have been traditionally used in Indian folk medicine (Ayurveda) for treatment various chronic inflammatory diseases such as rheumatoid arthritis. Furthermore, are known to possess anticancer efficacy against human cancer types, e.g. gliomas, prostate cancer, or leukemia [2–4]. aim...

Way-finding pillars for tourists aid them in navigating an unknown area. The show nearby points of interest, offer information about public transport and provide a scale the neighbourhood. Through series studies with locals, we establish their different needs. In this space, developed Mappy, mobile application which augments enhances way-finding added digital layer. Mappy opens up opportunities reappropriation of, engagement with, pillars. Seeing beyond initial use case by involving diverse...

Quadruped robots are proliferating in industrial environments where they carry sensor suites and serve as autonomous inspection platforms. Despite the advantages of legged over their wheeled counterparts on rough uneven terrain, still yet to be able reliably negotiate ubiquitous features infrastructure: ladders. Inability traverse ladders prevents quadrupeds from inspecting dangerous locations, puts humans harm's way, reduces site productivity. In this paper, we learn quadrupedal ladder...

For most of human history there existed a well-educated and innovative elite whereas mass education, market R&D, high growth are phenomena the modern period. In order to explain these we propose an innovation-driven model for very long run in which individual-specific return education is conceptualized as compound cognitive ability family background. This allows us establish locally stable steady state at background determines whether individual experiences determined by ability. Compulsory...

Since lack of movement constitutes a risk factor for dementia, increasing mobility older adults is important. We present three technological prototypes, which gear towards mobility, while considering issues such as privacy, autonomy, daily routines, accessibility and shared responsibility, raised in series workshops. An expert review the prototypes especially highlights importance privacy autonomy need holistic perspective when designing technology with dementia well their relatives other caregivers.

This paper addresses methodological considerations of participation in design for ageing. Based on the notions culture, communities everyday practice and situated elderliness we present accounts from two settings discuss issues related to mobilizing senior citizens co-design work.

‘Robots in healthcare’ is a very trending topic. This paper gives an overview of currently and commonly used methods to gather user needs requirements research projects the field assistive robotics. Common strategies between authors are presented as well examples exceptions, which can help future researchers find suitable for their own work. Typical problems discussed partial solutions proposed.

The field of “AAL Robotics”, combining AAL and robotics as disciplines, has not yet been precisely defined does present accepted structures concepts that would allow to communicate unequivocally its methods, projects, approaches. paper presents a method defining categorizing robots the resulting classes with regard activities they assist. classification is useful in it able cover breadth field, but more fine-grained description functionalities will be needed further...