A5101774866- Virus-based gene therapy research
- Animal Virus Infections Studies
- Nuclear Structure and Function
- RNA Research and Splicing
- Viral gastroenteritis research and epidemiology
- Cellular transport and secretion
- Alzheimer's disease research and treatments
- Plant tissue culture and regeneration
- Bacteriophages and microbial interactions
- Plant Stress Responses and Tolerance
- Calcium signaling and nucleotide metabolism
- Herpesvirus Infections and Treatments
- Plant Molecular Biology Research
- Plant and animal studies
- Poxvirus research and outbreaks
- Nanocomposite Films for Food Packaging
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Blood properties and coagulation
- DNA Repair Mechanisms
- Phytochemical compounds biological activities
- Microbial Metabolism and Applications
- Bioactive natural compounds
- Plant Micronutrient Interactions and Effects
- Endoplasmic Reticulum Stress and Disease
Guangxi University
2024-2025
Columbia University
2019-2024
Ruijin Hospital
2023
Shanghai Jiao Tong University
2023
The First People's Hospital of Changde
2023
Columbia University Irving Medical Center
2018
Harbin Institute of Technology
2018
Hebei Agricultural University
2014
University of Toronto
2014
Chinese Academy of Medical Sciences & Peking Union Medical College
2013
Application of reverse transcription (RT)-PCR to detect small round-structured viruses (SRSVs) from fecal specimens patients with gastroenteritis has been insensitive because the tremendous sequence heterogeneity between strains. We have designed two RT-PCR primer sets (G-1 and G-2) based on nucleotide diversity in RNA polymerase gene SRSVs belonging distinct genogroups represented by Norwalk virus (primers G-1) Snow Mountain agent G-2). All 22 SRSV strains examined that had classified...
Rapid identification and differentiation of orthopoxviruses by PCR were achieved with primers based on genome sequences encoding the hemagglutinin (HA) protein, an infected-cell membrane antigen that distinguishes from other poxvirus genera. The initial step used a primer pair consensus for amplifying HA DNA fragment three known North American (raccoonpox, skunkpox, volepox viruses), second virtually entire open reading frame Eurasian-African (variola, vaccinia, cowpox, monkeypox, camelpox,...
Abstract Abiotic stress impairs plant growth and development, thereby causing low yield inferior quality of crops. Increasing studies reported that strigolactones (SL) are hormones enhance resistance by regulating physiological processes gene expressions. In this review, we introduce the response regulatory role SL in salt, drought, light, heat, cold cadmium stresses plants. This review also discusses how alleviate damage abiotic plants, furthermore, introducing mechanisms enhancing at...
BACKGROUND: Mutations in LMNA encoding nuclear envelope proteins lamin A/C cause dilated cardiomyopathy. Activation of the AKT/mTOR (RAC-α serine/threonine-protein kinase/mammalian target rapamycin) pathway is implicated as a potential pathophysiologic mechanism. The aim this study was to assess whether pharmacological inhibition mTOR signaling has beneficial effects on heart function and prolongs survival mouse model disease, after onset failure. METHODS: We treated male Lmna H222P/H222P...
Cold stress, as an environmental factor that seriously restricts the growth, production and survival of plants, has received extensive attention in recent years. Nitric oxide (NO), important bioactive molecule, emerged a research focus domain alleviating plant cold damage. In this review, role NO enhancing tolerance its underlying mechanisms, including interactions with signaling molecules, are discussed more extensively, novel directions prospects proposed according to existing gaps....
SUMMARY Determining the causes and evolution of reproductive barriers to gene flow between populations, speciation, is key understanding origin diversity in nature. Many species manifest hybrid breakdown when they intercross, characterized by increasingly exacerbated problems later generations hybrids. Recently, Caenorhabditis nematodes have emerged as a genetic model for studying here we investigate nature remanei C . latens We quantify partial F 1 inviability extensive 2 inviability; ∼75%...
Atrial fibrillation (AF) is an age-related disease, while telomeres play a central role in aging. But the relationship between AF and telomere length (LTL) still controversial. This study aims to examine potential causal association LTL by using Mendelian randomization (MR).Bidirectional two-sample MR, expression protein quantitative trait loci (eQTL pQTL)-based MR were performed genetic variants from United Kingdom Biobank, FinnGen, meta-analysis study, which comprised nearly 1 million...
Background Low back pain (LBP) is a common condition and leading cause of health function loss worldwide. This study assessed the impact occupational factors on LBP using Mendelian Randomization (MR) method, controlling for confounding variables. Methods Based publicly available genome-wide association studies (GWAS), two-sample univariate multivariate MR analyses were performed to assess causal effect LBP. We used inverse variance weighted (IVW) method sensitivity generate total results...
Striking similarities between vaccinia virus hemagglutinin (VVHA) and proteins belonging to the Ig superfamily clearly indicate that VVHA, a 315-amino acid glycoprotein expressed on surface of infected cells, is novel viral protein can be added expanding list superfamily. Its deduced amino sequence contains one Ig-like domain at NH2 terminus, followed by two tandem repeating units hydrophobic region, suggestive membrane spanning. The results offer an opportunity for further study probable...
There are controversies on the pathophysiological alteration in patients with atrial fibrillation (AF) undergoing pulmonary vein isolation using different energy sources.We evaluated changes plasma proteins acute phase post-ablation receiving cryoballoon ablation, radiofrequency balloon or ablation.Blood samples from eight healthy controls and 24 AF were taken day of admission, 1, 2 analyzed by Olink proximity extension assay. Proteins identified performed enrichment analysis....
Influenza B virus is a cause of substantial morbidity and mortality in humans current vaccination strategies antiviral drugs only provide limited protection. Here, we report the evaluation small interfering RNA (siRNA) for repression viral replication cultured cells as well chicken embryos. Several siRNAs targeting conserved regions (in chemically synthesized or plasmid-encoded forms) were found to effectively block influenza virus. The offer broad protection over several strains...
Background Human adenoviruses (HAdVs) have been implicated as important agents in a wide range of human illnesses. To date, 58 distinct HAdV serotypes identified and can be grouped into six species. For the immunological diagnosis adenoviruses, hexon protein, structural has used. The potential other proteins not fully addressed. Methodology/Principal Findings In this study, nonstructural antigenic DNA binding protein (DBP) adenovirus 5 35 (Ad5, Ad35) - was using immunoproteomic technology....
Laser Induce Fluorescence (LIF) is a widely used new telemetry technology. It obtains information about oil spill and film thickness by analyzing the characteristics of stimulated fluorescence has an important application in field rapid analysis water composition. A set LIF detection system for marine pollution designed this paper, which uses 355nm high-energy pulsed laser as excitation light source. high-sensitivity image intensifier detector. The upper machine sends digital signal through...
Abstract Emerging studies implicate Tau as an essential mediator of neuronal atrophy and cognitive impairment in Alzheimer’s disease (AD), yet the factors that precipitate dysfunction AD are poorly understood. Chronic environmental stress elevated glucocorticoids (GC), major hormones, associated with increased risk AD, have been shown to trigger intracellular accumulation downstream Tau-dependent dysfunction. However, mechanisms through which GC disrupt clearance degradation neurons remain...
<p>Metacore pathway analysis of Nanostring gene expression data.</p>
<div>Abstract<p>Prostate cancer is common in countries with affluent dietary patterns and represents a heterogeneous collection of subtypes varying behavior. Reductionist strategies focusing on individual nutrients or foods have not clearly defined risk factors. We developed mechanisms-based upon inflammation chronic insulin hypersecretion, processes that are hypothesized to impact prostate carcinogenesis. In the Prostate, Lung, Colorectal, Ovarian cohort, we calculated empirical...
Objectives: To assess whether inhibition of cardiotoxic signaling pathways can prolong survival and improve cardiovascular function in a mouse model cardiomyopathy caused by lamin A/C gene (LMNA) mutation. Background: Mutations LMNA cause dilated arrhythmia. Activation the AKT serine/threonine kinase (AKT)/mechanistic target rapamycin (mTOR) pathway is implicated as potential pathophysiologic mechanism. Initial preclinical studies suggest targeting mTOR may increase survival, though have had...