A5047600624- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Corrosion Behavior and Inhibition
- Smart Materials for Construction
- Osteoarthritis Treatment and Mechanisms
- Concrete Corrosion and Durability
- Electrophoretic Deposition in Materials Science
- Gas Sensing Nanomaterials and Sensors
- Bone Tissue Engineering Materials
- TiO2 Photocatalysis and Solar Cells
- Extracellular vesicles in disease
- Cardiac Imaging and Diagnostics
- Cardiac Arrest and Resuscitation
- Analytical Chemistry and Sensors
- Water Quality Monitoring and Analysis
- Orthopaedic implants and arthroplasty
- Metal and Thin Film Mechanics
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Anodic Oxide Films and Nanostructures
- Hydrogen embrittlement and corrosion behaviors in metals
- Electrocatalysts for Energy Conversion
- Cardiovascular Function and Risk Factors
Ruijin Hospital
2014-2025
Shanghai Jiao Tong University
2014-2025
Zhejiang University
2021-2024
Second Affiliated Hospital of Zhejiang University
2021-2024
Zhejiang Lab
2022-2024
Fujian Provincial Hospital
2021-2024
Fujian Medical University
2021-2024
Zhejiang University Medical College Affiliated Stomatological Hospital
2021-2023
Blood Center of Zhejiang Province
2021
Rigshospitalet
2017
This study aimed to evaluate the long-term efficacy and clinical outcomes of catheter ablation performed with cryoballoon (CRYO) in comparison robotic magnetic navigation (RMN) patients persistent atrial fibrillation (PersAF). A total 200 symptomatic PersAF were prospectively enrolled non-randomly assigned (1:1) CRYO or RMN guided-ablation group undergoing pulmonary vein isolation (PVI) additional linear if necessary then followed up over 5 years. The primary endpoint was freedom from...
A novel porous nano hydroxyapatite (HA) coating has been prepared on commercially pure titanium substrate by a modified electrochemical deposition method. The physico-chemical and biological properties of the were characterized SEM, XRD, FTIR, Raman, in vitro cell culture test respectively. SEM patterns show uniform microporous morphology consisting wirelike crystals at nanometer scale. It is suggested that under controlled conditions, primary HA nanowires grow self-assemble to construct an...
The involvement of chondrocyte ferroptosis in the development osteoarthritis (OA) has been observed, and Sarsasapogenin (Sar) therapeutic promise a variety inflammatory diseases. This study investigates potential influence Sar on mechanism ferroptotic cell death progression osteoarthritic cartilage degradation. An vivo medial meniscus destabilization (DMM)-induced OA animal model as well an vitro examination chondrocytes microenvironment induced by interleukin-1β (IL-1β) exposure were...
Biological performance of artificial implant materials is closely related to their surface characteristics, such as microtopography, and composition. Therefore, convenient fabrication with a cell-friendly structure suitable composition was great significance for current tissue engineering. In this work, titanate nanotubular were successfully fabricated through simple chemical treatment. Immersion test in simulated body fluid vitro cell culture used evaluate the biological treated samples....
Competitive endogenous RNAs (ceRNAs), as a newly identified regulating mechanism, have been demonstrated to play crucial role in various human diseases. An increasing number of recent studies revealed that circular (circRNAs) can function ceRNAs. However, little is known about the circFAM160A2 pathological process osteoarthritis (OA). This study first examine circFAM160A2‐miR‐505‐3p‐SIRT3 axis progression. miR‐505‐3p was selected from interaction microRNA (miRNA) microarray comparing...
Abstract Background Atrial fibrillation (AF) is the most common cardiac heterogeneous rhythm disorder. It represents a major cause of mortality and morbidity, mainly related to embolic events heart failure. Mechanisms AF are complex remain incompletely understood. Recent evidence suggests exosomes membrane-coated objects released by many cell-types. Their presence in body fluids variable surface composition content render them attractive as mechanism for potential biomarkers. However, serum...
Tendinopathy is a disabling musculoskeletal disease, the pathological process of which tightly associated with inflammation. Spironolactone (SP) has been widely used as diuretic in clinical practice. Recently, SP shown anti-inflammatory features several diseases. Tendon-derived stem cells (TDSCs), subset cell type from tendon tissue possessing clonogenic capacity, play vital role tendinopathy. In present study, protective effect on TDSCs was demonstrated under simulated tendinopathy conditions both
Osteoarthritis (OA) is one of the most common chronic musculoskeletal disorder worldwide, representing a major source disability, pain and socioeconomic burden. Yet effective pharmaceutical treatments applied in clinical works are merely symptomatic management with uncertainty around their long-term safety efficacy, namely no drugs currently capable modulating biological progression OA. Here, we identified potent anti-inflammatory as well anti-oxidative properties Nitidine Chloride (NitC),...
Abstract Background Early recurrence (ER) after catheter ablation for atrial fibrillation (AF) has been considered as a common phenomenon but its mechanism and implication in long-term outcome not fully elucidated. We aimed to clarify the relation between post-ablation inflammation ER cryoballoon (CBA) or radio-frequency (RFA) evaluate clinical significance of ER. Methods A total 154 patients with paroxysmal AF undergoing were consecutively recruited, including 90 RFA (RF group) 64 CBA (CB...
Abstract In this study, a novel nano‐micro structured octacalcium phosphate/protein (OCP/protein) composite coating has been successfully constructed on titanium substrate by using an electrochemically induced deposition technique. The structure and composition of the were investigated XRD, XPS, SEM FTIR. It is shown that consists OCP protein with highly ordered hierarchically porous in scale, similar to naturalbone structure. nanoindentation experiment proves good mechanical property for...
Introduction: Some studies have shown that the defibrillation threshold (DFT) differs between short-duration ventricular fibrillation (SDVF, <1 minute) and long-duration (LDVF > 1 minute). The goal of this study is to evaluate effects acute intravenous amiodarone on SDVF-DFT LDVF-DFT its possible mechanism as well. Methods: Twelve open-chest dogs were randomly divided into 2 groups (control group, normal saline, 10 mL·kg−1·h−1 maintenance, n = 6; loading dose mg/kg over minutes, maintenance...
Introduction: Currently, numerous ablation techniques are available for atrial fibrillation (AF), in addition to manual radio frequency ablation. The aim of this prospective, non-randomized concurrent controlled trial was compare the mid-term efficacy and procedural outcomes persistent AF (PerAF) using cryoballoon (CB) robotic magnetic navigation (RMN). Methods: Two hundred PerAF patients were assigned, a 1:1 ratio, undergo catheter RMN (RMN group) or CB (CB group). primary endpoint freedom...
Abstract Background Osteoarthritis (OA) is a debilitating disease that inflicts intractable pain, major problem humanity faces, especially in aging populations. Stem cells have been used the treatment of many chronic diseases, including OA. Cartilage progenitor/stem (CPSCs) are type stem with ability to self- renew and differentiate. They hold promising future for understanding progression OA its treatment. Previous studies reported relationship between mitochondrial dynamics mesenchymal...
Background As a valuable blood glucose measurement, HemoglobinA1c (HbA1c) is of great clinical value for diabetes. However, in previous observational studies, studies on its effect bone mineral density (BMD) have different results. This study aimed to use Mendelian randomization (MR) assess the HbA1c and fracture risk, try further explore whether this association was achieved through glycemic or non-glycemic factors. Methods Take measurement as exposure, BMD estimated from quantitative heel...
Abstract Autophagy and cytoskeleton integrity of chondrocytes are a considered as major factors in the progression osteoarthritis (OA) involving excessive chondrocyte apoptosis senescence. Nesfatin-1, an adipokine, has been reported to be closely related cell autophagy malfunction. Our previous study found that nesfatin-1 was highly correlated with OA progress patient, expression rises knee articular tissue, serum chondrocytes. In current study, we aimed explore therapeutic effect on its...
Abstract Background There have been advancements of sophisticated mapping systems used for ablation procedures over the last decade. Utilization these novel in combination with remote magnetic navigation (RMN) needs to be established. We investigated new EnSite Precision system (St. Jude Medical, Inc., St. Paul, MN, USA), which collects data checking field stability and is built on an open platform, allowing physicians choose diagnostic catheters. address its compatibility RMN. Objective To...
The objective of this study was to assess the impact steerable sheaths compared with fixed-curve on procedural outcomes atrial fibrillation (AF) ablation guided by robotic magnetic navigation (RMN).In retrospective case-control study, 110 patients scheduled for AF catheter were enrolled and divided into two groups. Fifty-five (paroxysmal, 70%) treated RMN-guided utilizing a sheath another 55 ablated RMN using sheath. Clinical characteristics similar between Compared group, group procedure...
Myeloperoxidase (MPO), released by activated neutrophils, is significantly increased in atrial fibrillation (AF). MPO may play a role the progression of and further involved AF recurrence after catheter ablation. We compared plasma levels paroxysmal persistent explored their ablation.Plasma were measured consecutive patients with (n = 225) 106). Samples collected from femoral vein during ablation all included followed up to (56.31 [40.33-73.51] vs. 64.11 [48.65-81.11] ng/ml, p < 0.001)....
To investigate the immunology shared mechanisms underlying chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2DM) examine impact of anti-diabetic drugs on acute exacerbation COPD (AECOPD). We analyzed GSE76925, GSE76894, GSE37768, GSE25724 to identify differentially expressed genes. Hub-genes were identified through protein–protein interaction network analysis evaluated by receiver operating characteristic curve. CXCL12 emerged as a robust biomarker, its correlation...