A5016390421- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Cardiac, Anesthesia and Surgical Outcomes
- Orthopaedic implants and arthroplasty
- Cerebrovascular and Carotid Artery Diseases
- Additive Manufacturing and 3D Printing Technologies
- Dental Implant Techniques and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Acute Ischemic Stroke Management
- Aortic aneurysm repair treatments
- Tissue Engineering and Regenerative Medicine
- Intensive Care Unit Cognitive Disorders
- Anatomy and Medical Technology
- Diet and metabolism studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Magnesium Alloys: Properties and Applications
- MicroRNA in disease regulation
- Dental materials and restorations
- Reproductive tract infections research
- Hemodynamic Monitoring and Therapy
- Magnesium Oxide Properties and Applications
- Effects of Vibration on Health
- Titanium Alloys Microstructure and Properties
- Nerve injury and regeneration
- Healthcare Decision-Making and Restraints
Chinese PLA General Hospital
2022-2025
Stomatology Hospital
2017-2024
Zhejiang University
2015-2024
Jinzhou Medical University
2024
Hangzhou Academy of Agricultural Sciences
2020
Indiana University School of Medicine
2015-2020
Hangzhou Xixi hospital
2015-2020
First Hospital of China Medical University
2019
China Medical University
2019
Zhejiang University Medical College Affiliated Stomatological Hospital
2017-2019
Three-dimensional (3D) printing bioactive ceramics have demonstrated alternative approaches to bone tissue repair, but an optimized materials system for improving the recruitment of host osteogenic cells into defect and enhancing targeted repair thin-wall craniomaxillofacial defects remains elusive. Herein we systematically evaluated role side-wall pore architecture in direct-ink-writing bioceramic scaffolds on mechanical properties capacity rabbit calvarial defects. The pure calcium...
Abstract Desktop three-dimensional (3D) printers (D3DPs) have become a popular tool for fabricating personalized consumer products, favored low cost, easy operation and other advantageous qualities. This study focused on the potential using D3DPs to successfully, rapidly economically print customized implants at medical clinics. An experiment was conducted D3DP-printed anterior cruciate ligament surgical implant rabbit model. A well-defined, orthogonal, porous PLA screw-like scaffold...
Implanting artificial biomaterial implants into alveolar bone defects with individual shape and appropriate mechanical strength is still a challenge. In this study, bioceramic scaffolds, which can precisely match the mandibular in macro micro, were manufactured by 3-dimensional (3D) printing technique according to computed tomography (CT) image. To evaluate stimulatory effect of material substrate on tissue regeneration situ rabbit defect model, made newly developed, mechanically strong ~10%...
Here, a novel direct ink printing method was developed to print high-strength chitosan hydrogel scaffolds without any organic solvents.
As a projection based three-dimensional printing method, digital light processing bioprinting (DLPBP) has higher resolution and is suitable for constructing finer structures to mimic tissues when compared extrusion bioprinting. However, there lack of understanding about behavior during DLPBP. Herein, photo crosslinking theory ink was established specified amount absorber added control depth. Then, standardized methodology quantitatively evaluate using different parameters. Complex...
Abstract Reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a challenge, as chronic local inflammation can largely impair healing. Here, we used magnesium silicate nanospheres (MSNs) to load microRNA-146a-5p (miR-146a) fabricate nanobiomaterial, MSN+miR-146a, which showed synergistic promoting effects on the osteogenic differentiation human dental pulp stem cells (hDPSCs). In addition, miR-146a exhibited anti-inflammatory effect mouse...
Background Perioperative stroke is a serious and potentially fatal complication following non-cardiac surgery. Thus, it important to identify the risk factors develop an effective prognostic model predict incidence of perioperative Methods findings We identified potential built using logistic regression derived from hospital registry data adult patients that underwent surgery 2008 2019 at The First Medical Center Chinese PLA General Hospital. Our was then validated records two additional...
Abstract Wollastonite (CaSiO3; CSi) ceramic is a promising bioactive material for bone defect repair due to slightly fast degradation of its porous constructs in vivo . In our previous strategy some key features CSi have been significantly improved by dilute magnesium doping regulating mechanical properties and biodegradation. Here we demonstrate that 6 ~ 14% Ca substituted Mg (CSi-Mgx, x = 6, 10, 14) can enhance the strength (>40 MPa) but not compromise biological performances 3D printed...
Using artificial biomaterials in bone regenerative medicine for highly efficient osteoconduction into the defect to decrease healing time is still a challenge. In this research, magnesium (Mg)-doped wollastonite (∼10% Mg was substituted calcium (Ca) β-CaSiO3) (CSi-Mg10) bioceramic scaffolds with ultrahigh mechanical strength were fabricated using ceramic ink writing three dimensional (3D) printing. To evaluate potential of other additives on new regeneration efficiency, β-tricalcium...
Nucleus pulposus (NP) degeneration is the major cause of degenerative disc disease (DDD). This condition cannot be treated or attenuated by traditional open minimally invasive surgical options. However, a combination stem cells, growth factors (GFs) and biomaterials present viable option for regeneration. Injectable act as carriers controlled release GFs deliver cells to target tissues through approach. In this study, injectable gelatin methacryloyl microspheres (GMs) with controllable,...
A 3D cell culture has developed rapidly in recent years, as cells growing on a flat substrate static environment are far from achieving an vivo status. Currently, researchers have also gradually realized that to achieve morphology, structure, and physiological functions vitro, should be capable of simulating key features environment, including the interaction cell–cell, cell–extracellular matrix (ECM), cell–organ interactions. Herein, development system related following three perspectives...
Abstract Background Postoperative cognitive impairment are common neural complications in older surgical patients and exacerbate the burden of medical care on families society. Methods A total 140 who were scheduled for elective orthopaedic surgery or pancreatic with general anaesthesia randomly assigned to Group S I a 1:1 allocation. Patients received intranasal administration 400 μL normal saline 40 IU/400 insulin, respectively, once daily from 5 minutes before induction until 3 days...
Abstract Background Postoperative delirium (POD) is more prevalent among elderly patients with type 2 diabetes mellitus (T2DM). Insulin resistance (IR) can be assessed using the triglyceride-glucose (TyG) index, a novel biomarker. This study aims to investigate predictive potential of TyG index for POD in T2DM. Materials and methods Elderly (≥ 65) T2DM who underwent non-neurosurgery non-cardiac surgery were enrolled. Univariate multivariate logistic regression analyses conducted assess...
The regeneration and repair of damaged load-bearing segmental bones require considerable mechanical strength for the artificial implants. ideal biomaterials should also facilitate production porous implants with high bioactivity desirable stimulating new bone growth. Here we developed a mechanically strong, highly bioactive dilute magnesium-doped wollastonite (CaSiO3-Mg; CSi-Mg) scaffold by robocasting technique. sintered scaffolds had interconnected pores 350 µm in size over 50% porosity...
Abstract Background The prognostic nutritional index (PNI) is a indicator and predictor of various diseases. However it unclear whether PNI can be perioperative ischemic stroke. This study aims to evaluate the association preoperative stroke in patients undergoing non-cardiac surgery. Methods retrospective cohort included who underwent noncardiac surgery between January 2008 August 2019. were divided into ≥ 38.8 < groups according cut-off value PNI. Univariate multivariate logistic...
Well-organized orientation of cells and anisotropic extracellular matrix (ECM) are crucial in engineering biomimetic tissues, such as muscles, arteries, nervous system, so on. This strategy, however, is only beginning to be explored. Here, we demonstrated a light-induced cell alignment harvest for sheets (ACS) technology using light-responsive TiO2 nanodots film (TNF) photo-cross-linkable gelatin methacrylate (GelMA). Cell initial behaviors on TNF might controlled by micropatterns distinct...
Some Ca-Mg-silicate ceramics have been widely investigated to be highly bioactive and biodegradable, whereas their osteogenic potential especially biomechanical response in the early stage vivo are scarcely demonstrated. Herein, osteogenesis capacity mechanical evolution of akermanite (Ca2MgSi2O7) porous materials manufactured by ceramic ink writing three-dimensional printing technique were systematically a critical size femur defect model, comparison with clinically available β-tricalcium...
Osteomyelitis, caused by purulent bacteria invading bone tissue, often occurs in long bones and seriously affects the physical mental health working ability of patients; it can even endanger life. However, due to cavity structure, osteomyelitis tends occur inside thus lacks an effective treatment; anti-inflammatory treatment repair defects are necessary. Here, we developed injectable hydrogel microspheres loaded with naringin marrow mesenchymal stem cells, which have osteogenic properties....
Body mass index (BMI) serves as a global metric for assessing obesity and overall health status. However, the impact of BMI, treated continuous variable, on risk perioperative stroke remains poorly understood. This retrospective cohort study aimed to elucidate association between BMI ischemic in patients undergoing non-cardiovascular surgery.
To investigate the association between coronary heart disease (CHD) and risk of perioperative ischemic stroke in patients undergoing noncardiac surgery.