A5102964145- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Natural product bioactivities and synthesis
- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- Circular RNAs in diseases
- Hip disorders and treatments
- Protease and Inhibitor Mechanisms
- Total Knee Arthroplasty Outcomes
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Knee injuries and reconstruction techniques
- Laser Applications in Dentistry and Medicine
- Sports injuries and prevention
- Ferroptosis and cancer prognosis
- Dental Implant Techniques and Outcomes
- Chemokine receptors and signaling
- Endoplasmic Reticulum Stress and Disease
- Macrophage Migration Inhibitory Factor
- Nuclear Receptors and Signaling
- Caveolin-1 and cellular processes
- Extracellular vesicles in disease
Second Affiliated Hospital of Zhejiang University
2016-2025
Tongji University
2025
Zhejiang University
2015-2024
Zhejiang Lab
2024
Beijing University of Chemical Technology
2024
Blood Center of Zhejiang Province
2021
Zhejiang University Medical College Affiliated Stomatological Hospital
2021
Institute of Zoology
2019
Chinese Academy of Sciences
2019
Indiana University School of Medicine
2015-2016
Abstract Desktop three-dimensional (3D) printers (D3DPs) have become a popular tool for fabricating personalized consumer products, favored low cost, easy operation and other advantageous qualities. This study focused on the potential using D3DPs to successfully, rapidly economically print customized implants at medical clinics. An experiment was conducted D3DP-printed anterior cruciate ligament surgical implant rabbit model. A well-defined, orthogonal, porous PLA screw-like scaffold...
Introduction: Osteoarthritis (OA) is the most prevalent joint disorder in elderly population, and inflammatory mediators like IL-1βwere thought to play central roles its development. Schisandrin B, main active component derived from Schisandra chinensis , exhibited antioxidative antiinflammatory properties. Methods: In present study, protective effect underlying mechanism of B on OA was investigated vivo vitro. Results: The results showed that decreased IL-1β-induced upregulation matrix...
Abstract Wollastonite (CaSiO3; CSi) ceramic is a promising bioactive material for bone defect repair due to slightly fast degradation of its porous constructs in vivo . In our previous strategy some key features CSi have been significantly improved by dilute magnesium doping regulating mechanical properties and biodegradation. Here we demonstrate that 6 ~ 14% Ca substituted Mg (CSi-Mgx, x = 6, 10, 14) can enhance the strength (>40 MPa) but not compromise biological performances 3D printed...
Metabolic disorders and inflammation of chondrocytes are major pathological changes in aging cells osteoarthritis (OA). Recent studies demonstrated age-related mitochondrial dysfunction may be a key contributing factor the development OA. Mitofusin 2 (MFN2) is regulator fusion, cell metabolism, autophagy apoptosis. This study was performed to ascertain whether MFN2 involved OA.Metabolic measurements were taken rat between different ages (3-week, 5-month, 12-month). activity detected both...
The regeneration and repair of damaged load-bearing segmental bones require considerable mechanical strength for the artificial implants. ideal biomaterials should also facilitate production porous implants with high bioactivity desirable stimulating new bone growth. Here we developed a mechanically strong, highly bioactive dilute magnesium-doped wollastonite (CaSiO3-Mg; CSi-Mg) scaffold by robocasting technique. sintered scaffolds had interconnected pores 350 µm in size over 50% porosity...
Osteoarthritis (OA) is a chronic degenerative joint disease, related to the overexpression of matrix metalloproteinases (MMPs), disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS), inflammation, chondrocyte apoptosis. Nesfatin-1 an adipokine, which plays important role in development OA, especially obese people. In present study, cartilage degradation apoptosis observed OA patients was evaluated. Furthermore, anti-inflammatory anti-apoptotic effects nesfatin-1, its...
Long-term chronic inflammation after Achilles tendon injury is critical for tendinopathy. Platelet-rich plasma (PRP) injection, which a common method treating tendinopathy, has positive effects on repair. In addition, tendon-derived stem cells (TDSCs), are located in tendons, play major role maintaining tissue homeostasis and postinjury this study, injectable gelatine methacryloyl (GelMA) microparticles containing PRP laden with TDSCs (PRP-TDSC-GM) were prepared by projection-based 3D...
Some Ca-Mg-silicate ceramics have been widely investigated to be highly bioactive and biodegradable, whereas their osteogenic potential especially biomechanical response in the early stage vivo are scarcely demonstrated. Herein, osteogenesis capacity mechanical evolution of akermanite (Ca2MgSi2O7) porous materials manufactured by ceramic ink writing three-dimensional printing technique were systematically a critical size femur defect model, comparison with clinically available β-tricalcium...
Abstract Diabetes mellitus (DM) is one of the prominent risk factors for pathological development and progression tendinopathy. One feature DM‐related changes in tendinopathy accumulation advanced glycation end products (AGEs) affected tendons. Pioglitazone (Pio), a peroxisome proliferator‐activated receptor γ agonist, performs protective effect against AGEs. The present study aimed to investigate pathogenetic role AGEs on tendon‐derived stem cells (TDSCs) determine Pio AGEs‐induced TDSC...
Osteoarthritis (OA) is the most prevalent joint disease and uncontrolled inflammation now recognized to play vital roles in OA development. The orphan nuclear receptor 4A1(NR4A1) a key negative regulator of inflammatory responses but its role osteoarthritis remains unclear. In present study, we found that NR4A1 expression was elevated human cartilage vitro model, which could be blocked by NF-κB signal inhibitor JSH23. overexpression inhibited, whereas knockdown enhanced IL-1β induced COX-2,...
NR4A3 is a member of nuclear receptor subfamily 4, which an important regulator cellular function and inflammation. In this study, high expression in human osteoarthritis (OA) cartilage was firstly observed. To explore the relationship between OA, we used lentivirus overexpression system to simulate its study role OA. Additionally, siRNA-mediated knockdown confirm findings experiments. The results showed stimulatory effect IL-1β on matrix-degrading enzyme such as MMP-3, 9, INOS COX-2...
Tendinopathy is a common musculoskeletal disorder, mainly affects the athletes and aged people. Tumor necrosis factor-α (TNF-α) plays an initiator role in tendinopathy. Tectorigenin extract component of Belam-canda Chinesis, which performs anti-inflammatory anti-apoptosis effects. The present study stablished to investigate tectorigenin against pathogenetic effects TNF-α on tendon-derived stem cells (TDSCs) vivo vitro. findings indicated that able induce TDSC inflammation, apoptosis...
Heterotopic ossification (HO) is a pathological condition involved in tendinopathy. Adipokines are known to play key role HO of Nesfatin-1, an 82-amino acid adipokine closely reportedly associated with diabetes mellitus (DM), which, turn, related In the present study, we aimed investigate effects nesfatin-1 on osteogenic differentiation tendon-derived stem cells (TDSCs) and pathogenesis tendinopathy rats. vitro , TDSCs were incubated induction medium for 14 days different concentration. vivo...
Factors affecting the mechanical properties of high-damping rubber plate mainly include temperature, shear strain rate, amplitude, and compressive stress. However, existing studies focused on one factor have not conducted detailed research coupling relationships between various factors. The influence will change with in other To study correlation, a series horizontal cyclic loading tests were designed carried out. Due to simultaneous hyperelastic viscoelastic rubber, hysteresis curve is...
Herein we systematically investigated the biological performance of a β-dicalcium silicate (β-C<sub>2</sub>S)-based bone cement in comparison with clinically used calcium phosphate (CPC) and Bio-Oss®.
Several studies have investigated strategies to improve the clinical efficacy of radiotherapy (RT) against hepatocellular carcinoma (HCC), yet prognosis remains poor. Human adipose tissue-derived mesenchymal stem cells (AT-MSCs), easily accessible and abundant in quantity, represented as an attractive therapeutic tool for cell-based treatment cancer diseases. Through direct co-culture indirect separate culture experiments, we showed that AT-MSCs could enhance inhibitory effect RT on reducing...
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by deterioration of articular cartilage. Dual specificity phosphatase 5 (DUSP5), member the DUSP subfamily, known to regulate cellular inflammation. Here, we studied relationship between DUSP5 and OA knockdown overexpression DUSP5, respectively. Results from in vitro experiments demonstrated that increased interleukin-1β (IL-1β)-induced expression inflammatory genes, such as inducible nitric oxide synthase (iNOS),...
As a joint disease, osteoarthritis (OA) is caused by the breakdown of subchondral bone and cartilage damage. Inflammatory factors, such as interleukin- (IL-) 1 β , mediate progression OA. Madecassoside (MA), triterpenoid component derived from gotu kola herb ( Centella asiatica ), exhibits various pharmacological effects, including antioxidative anti-inflammatory properties. In present study, protective effects possible mechanism MA on treatment OA were investigated. was demonstrated to...