A5101602265- Sexual function and dysfunction studies
- Sperm and Testicular Function
- Urinary Bladder and Prostate Research
- Reproductive Biology and Fertility
- Reproductive Health and Technologies
- Curcumin's Biomedical Applications
- Hormonal and reproductive studies
- Genital Health and Disease
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Heavy Metal Exposure and Toxicity
- Eating Disorders and Behaviors
- Pelvic floor disorders treatments
- Mesenchymal stem cell research
- Healthcare and Venom Research
- Ureteral procedures and complications
- Renal and related cancers
- Psychosomatic Disorders and Their Treatments
- Urological Disorders and Treatments
- Sarcoma Diagnosis and Treatment
- Testicular diseases and treatments
- Pediatric Urology and Nephrology Studies
- Tissue Engineering and Regenerative Medicine
- Acupuncture Treatment Research Studies
- Dietary Effects on Health
- Coconut Research and Applications
Nanjing Drum Tower Hospital
2016-2024
Nanjing Medical University
2017-2024
Creative Commons
2023
Fujian Academy of Building Research (China)
2023
Wuxi People's Hospital
2023
Wuhan Center for Disease Control and Prevention
2023
Xuzhou Medical College
2014-2018
Second Affiliated Hospital of Nanjing Medical University
2018
Despite increasing understanding of the cerebral functional changes and structural abnormalities in erectile dysfunction, alterations topological organization brain networks underlying psychogenic dysfunction remain unclear.Here, based on diffusion tensor image data 25 patients 26 healthy controls, we investigated its correlations with clinical variables using graph theoretical analysis.Patients displayed a preserved overall small-world exhibited less connectivity strength left inferior...
Background: Neuroimaging studies have demonstrated that the prefrontal cortex and amygdala play an important role in sexual arousal (SA). However, little is known about interactions between amygdala, which mediate cognitive regulation of emotion SA. Objective: We seek to determine whether nocturnal erection psychogenic erectile dysfunction (pED) patients are normal there changes topological organization prefrontal-amygdala pathway brain network pED. In addition, correlations property...
The activation of tunica albuginea myofibroblasts (MFs) serves an essential role in Peyronie's disease (PD). Increasing evidence has reported that adipose tissue‑derived stem cells (ADSCs) have been demonstrated to attenuate the symptoms PD animal models. However, mechanisms antifibrotic effects ADSCs remain be fully elucidated. In present study, inhibitory and possible mechanism on MFs derived from rat penile were investigated. obtained paratesticular fat Sprague Dawley rats. transformed...
The present study aimed to evaluate the clinical outcomes of magnetic-activated cell sorting (MACS) in sperm preparation for male subjects with a DNA fragmentation index (DFI) ≥30%. A total 86 patients who had undergone their first long-term long protocol were selected. involved vitro fertilization (IVF) and intracytoplasmic injection (ICSI) cycles, divided into MACS or control groups. group included samples analyzed that combined density gradient centrifugation (DGC) swim-up (SU) technique...
To compare effects of repairing injured tunica albuginea (PTA) rat penis by single or repeated local injections chlorhexidine ethanol (ChE) into the PTA and to establish a new animal model Peyronie's disease (PD).Forty-two rats were divided 7 groups. Rats either served as normal control group with 1-5 0.9% saline they received injection, 2, 3, 4, 5 ChE (0.1% gluconate plus 15% dissolved in saline); positive injected TGF-β1. At 60 days after last intracavernous pressure, degree penile...
Abstract Adipose tissue-derived stem cells (ADSCs) have been shown to improve erectile function in animal models of dysfunction. However, few studies carried out using a reliable vivo imaging method trace transplanted real time, which is necessary for systematic investigation cell therapy. The study aims explore the feasibility non-invasively monitoring intracavernous injection ADSCs rat and miniature pig corpus cavernosum magnetic resonance (MR) imaging. Thirty-six male Sprague Dawley rats...
Background: The precise pathophysiology of venous erectile dysfunction (VED) was still unclear. Dynamic infusion cavernosometry and cavernosography (DICC) the gold standard approach for diagnoses VED. However, a operative procedure DICC needed it unclear whether could show promise in accurate assessment treatment aim this study to establish an optimized operation process evaluate efficacy therapy Methods: One hundred forty-seven VED patients identified by color doppler duplex ultrasonography...
Primary ciliary dyskinesia (PCD) is a rare hereditary orphan condition that results in variable phenotypes, including infertility. About 50 gene variants are reported the scientific literature to cause PCD, and among them, dynein axonemal assembly factor 4 ( DNAAF4 ) has been recently reported. implicated preassembly of multiunit protein essential for normal function locomotory cilia as well flagella. In current study, single patient belonging Chinese family was recruited, having diagnosed...
Recent research has highlighted structural and functional abnormalities in the cerebral cortex of patients with premature ejaculation (PE). These anomalies could play a pivotal role physiological mechanisms underlying PE. This study leveraged magnetic resonance imaging (fMRI), noninvasive technique, to explore these neural mechanisms. We conducted resting-state fMRI scans on 36 PE 22 healthy controls (HC), collected data Premature Ejaculation Diagnostic Tool (PEDT) scores intravaginal...
Silent information regulator 2-related enzyme 1 (SIRT1) is an aging-related protein activated with aging. Herein, we evaluated the role of SIRT1 in erectile dysfunction. The expression was modulated aged Sprague-Dawley rats following intragastric administration resveratrol (Res; 5 mg kg-1), niacinamide (NAM; 500 kg-1) or Res (5 + tadalafil (Tad; phosphodiesterase-5 [PDE5] inhibitor; for 8 weeks. Then, determined function by ratio intracavernosal pressure (ICP)/mean systemic arterial (MAP)....
Varicocele (VC) is a common cause of male infertility, but the molecular mechanisms involved in its pathogenesis are unknown. We investigated impact varicocelectomy (VCT) on proteome profiles testicular tissues rats with VC, and analysed associated target genes signalling pathways. Sixty VC were divided into two groups: control (n = 30), VCT 30). Tissues collected 4 weeks after sham or surgery. Matrix-assisted laser desorption/ionisation time-of-flight/time-of-flight mass spectrometry...
In the past 20 years, incidence of prostate cancer has risen rapidly. It been ranked as third most common malignant tumor male genitourinary system. Testicular metastasis is uncommon in cancer. Most cases are incidentally found treatment with orchiectomy. Therefore, we believed it was necessary to report case our patient this disease.We present a 69-year-old Han Chinese man high total prostate-specific antigen level. A transrectal ultrasound-guided biopsy performed. pathology showed tissue...
Abstract Introduction Primary intravaginal anejaculation (PIAJ) is a relatively uncommon male sexual dysfunction characterized by an inability to achieve ejaculation during all intercourse. Effective treatment options for this condition are lacking. We aimed explore the clinical effect of therapy combined with vacuum negative pressure hydropneumatic/pneumatic bubble massage (VNPHP/PBM) on primary anejaculation, and its possible mechanism. Methods A total 95 PIAJ patients were randomly...
Ejaculation is regulated by the central nervous system. However, pathophysiology of primary intravaginal anejaculation (PIAJ) unclear. The present study aimed to examine changes in regional brain activity and functional connectivity underlying PIAJ. A total 20 PIAJ patients 16 healthy controls (HCs) were enrolled from September 2020 2022 Department Andrology, Nanjing Drum Tower Hospital (Nanjing, China). Magnetic resonance imaging data acquired all participants then preprocessed. measures...
Introduction Although several observational studies have explored the association between sleep traits and risk of erectile dysfunction (ED), it remains controversial. In present study, we included a wide range that are commonly observed in clinical practice. We investigated causal relationship these ED using univariate multivariate Mendelian randomization (MR) methods. Material methods Instrumental variables (IVs) for eight (insomnia, duration, chronotype, apnea syndrome), five confounders...
Abstract Background Testicular metastasis from malignant solid tumors is extremely rare. It usually found by chance during autopsy or pathological examination of testicular specimens. Therefore, we consider it necessary to report our patient’s case colon cancer. Case presentation We a 61-year-old Han Chinese male patient who presented clinic with progressive painless swelling the right testicle for 2 years. Positron emission tomography–computed tomography scans showed increased...
PurposeThis study aimed to compare the risk of vagal reflex during microsurgical subinguinal varicocelectomy (MSV) under general anesthesia (GA) with or without additional local anesthetic (LA) spermatic cord block (SCB).MethodA single-center randomized controlled trial was conducted between January 2022 and June 2023.300 patients left-sided grade Ⅲ varicocele were randomly divided into two groups: SCB group (n = 153) control 147)(computer-generated random numbers list). During MSV GA, given...