A5101879889- Flavonoids in Medical Research
- Intracranial Aneurysms: Treatment and Complications
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cell Adhesion Molecules Research
- Viral Infections and Outbreaks Research
- Acupuncture Treatment Research Studies
- Viral Infections and Vectors
- Neonatal Respiratory Health Research
- Meta-analysis and systematic reviews
- Traumatic Brain Injury Research
- Cerebrovascular and Carotid Artery Diseases
- Ferroptosis and cancer prognosis
- Anorectal Disease Treatments and Outcomes
- Mosquito-borne diseases and control
- Galectins and Cancer Biology
- Wnt/β-catenin signaling in development and cancer
- Cardiac Arrhythmias and Treatments
- Neonatal and Maternal Infections
- Advanced Glycation End Products research
- Macrophage Migration Inhibitory Factor
- Male Reproductive Health Studies
Southwest Medical University
2019-2025
Affiliated Hospital of Southwest Medical University
2019-2025
Shenyang Anorectal Hospital
2025
Capital Medical University
2019-2025
Beijing Chao-Yang Hospital
2019-2025
University of Michigan
2024
Anhui Medical University
2022-2024
First Affiliated Hospital of Anhui Medical University
2022-2024
Nanjing Drum Tower Hospital
2024
Southern Medical University
2019-2023
Generalist foundation models such as GPT-4 have displayed surprising capabilities in a wide variety of domains and tasks. Yet, there is prevalent assumption that they cannot match specialist fine-tuned models. For example, most explorations to date on medical competency benchmarks leveraged domain-specific training, exemplified by efforts BioGPT Med-PaLM. We build prior study GPT-4's challenge the absence special training. Rather than using simple prompting highlight model's out-of-the-box...
Intracardiac leiomyomatosis (ICL) is an uncommon condition characterized by the proliferation of intravascular tissue within veins, leading to development tumor emboli. This can pose a significant threat life when invades cardiac structures. The diagnostic process for this complex and presents considerable challenges. We report case 38-year-old female patient whose pulmonary artery computed tomography (CT) revealed low density structure in branches artery. Echocardiography mobile right heart...
Background In our previous research, we addressed the issues of poor stability and water solubility scutellarin by developing nanoparticles. Our findings indicated that these nanoparticles exhibited enhanced anti-colon cancer activity compared to alone. However, underlying mechanisms scutellarin’s effects require further investigation. Scutellarin is known suppress proliferation different tumor cells. this study, explored whether scutellarin, encapsulated in nanoparticles, could colon cells...
Rapid advancements in large language models (LLMs) have increased interest deploying them on mobile devices for on-device AI applications. Mobile users interact differently with LLMs compared to desktop users, creating unique expectations and data biases. Current benchmark datasets primarily target at server environments, there is a notable lack of extensive specifically designed contexts. Additionally, face strict limitations storage computing resources, constraining model size...
Previous studies have reported that the long non-coding RNA SNHG12 (lncRNA SNHG12) plays a critical role in regulating function of mesenchymal stem cells (MSCs); however, effect lncRNA on MSCs injured brain tissue has rarely been reported. We studied and mechanism SNHG12-modified (MSCs) treating injuries caused by ischemia/reperfusion (I/R). I/R treated rat microvascular endothelial (BMECs) were co-cultured with or pretreated MSCs. Next, BMEC proliferation was detected using CCK-8 EdU...
Background: Glioma is the most common malignant tumor of central nervous system, and often displays invasive growth. Recently, circular RNA (circRNA), which a novel non-coding type RNA, has been shown to play vital role in glioma tumorigenesis. However, functions mechanism lipocalin-2 (Lcn2)-derived (hsa_circ_0088732) progression remain unclear. Methods: We evaluated hsa_circ_0088732 expression by fluorescence situ hybridization (FISH), Sanger sequencing, PCR assays. Cell apoptosis was flow...
Scutellarein has been identified to serve an anti‑tumor function in human colon cancer, but the underlying mechanisms remain largely unclear. The present study further investigated effect and mechanism of scutellarein, extracted from wild chrysanthemum, progression cancer. MTT, clone formation, flow cytometry tumor‑bearing mice assays were used detect cell viability, apoptosis tumorigenesis, respectively. Western blot quantitative PCR performed for protein mRNA expression detection. results...
Inflammation is known to play an important role in early brain injury (EBI) after subarachnoid hemorrhage (SAH). T cell immunoglobulin and mucin domain-3 (Tim-3) has emerged as a critical regulator of adaptive innate immune responses, been identified vital certain inflammatory diseases; The present study explored the effect Tim-3 on responses detailed mechanism EBI following SAH. We investigated effects SAH models established by endovascular puncture method Sprague-Dawley rats. studies...
Ras‑GTPase‑activating protein SH3 domain‑binding 1 (G3BP1) has been reported to be of importance in the occurrence and development colon cancer. However, underlying mechanisms remain largely unknown. Therefore, aim present study was investigate role Wnt/β‑catenin signaling G3BP1‑mediated cancer progression. The expression G3BP1 tissues cells detected via reverse transcription‑quantitative PCR, western blotting immunohistochemistry. Gain‑of‑function assays were performed RKO cells, which have...
Colorectal cancer (CRC) is one of the most common malignant tumors in world. Cases colon have experienced dramatic growth for past few decades China, while rate rectal descends 3% every year West. The purpose this study to reveal potential impact miR-21-5p on occurrence process CRC and its connection with a close homolog L1 (CHL1). In study, expression level miR-151-3p was found be significantly higher adenocarcinoma tissue compared adjacent normal tissues, CHL1 lower tissues. inversely...
Rapid endothelialization is extremely essential for the success of small-diameter tissue-engineered vascular graft (TEVG) (<6 mm) transplantation. However, severe inflammation in situ often causes cellular energy decline endothelial cells. The supply involved therapy remains unclear, and whether promoting would be helpful regeneration grafts needs to established. In our work, we generated an AMPK activator (5-aminoimidazole-4-carboxamide ribonucleotide, AICAR) immobilized graft....
Abstract Background The problems associated with the poor water solubility of anticancer drugs are one most important challenges in achieving effective cancer therapy. present study was designed to evaluate effect scutellarein on human colon cells vitro by using a target α v β3 novel (Scu)-loaded niosome nanoparticle (β-CD-CL-Scu-cRGD). Results β-CD-CL-Scu-cRGD has diameter 140.2 nm and zeta potential − 11.3 mV constant physicochemical stability. MTT assay showed both Scu caused decrease...
Although catheter ablation (CA) is an effective treatment for non-valvular atrial fibrillation (AF), a good many of patients still have recurrence following post-operation. Prediction AF by evaluating left (LA) phase function with speckle tracking echocardiography (STE) may be helpful risk stratification and clinical management patients. Therefore, the current study aimed to assess prognostic value LA strains in after CA.A total 95 (70.5% paroxysmal AF, 56.8% males, mean age 63.2 ± 9.7...
Previous studies have shown that ionized calcium (iCa) is strongly correlated with critical illnesses, including sepsis. However, there are few on the association of iCa levels and sepsis in very low birth weight infants (VLBWI). Therefore, aim this study was to investigate role assessing severity predicting prognosis VLBWI.249 eligible VLBWI were included present divided into good poor groups according prognosis. We collected complete laboratory clinical data. The lowest measured during...
Purpose: LncRNA TP73-AS1 has been demonstrated to promote the developments of several types human cancer. However, its role in colorectal cancer (CRC) is unknown. Methods: All CRC patients (n=70, 40 males and 30 females, 38 66 years’ old, 52.1 ± 5.3 old) this study were enrolled Affiliated Hospital Southwest Medical University from July 2012 January 2014. Cells, vectors, transient transfections, RT-qPCR, western-blotting, as well measurements cell migration invasion abilities carried out...
To compare the effect of electroacupuncture preconditioning with different frequencies on anal pain after milligan-morgan hemorrhoidectomy.A total 120 patients mixed hemorrhoids were randomly divided into an group A (dilatational wave, 2 Hz/100 Hz in frequency), B (continuous frequency) and C 100 40 cases each group. Electroacupuncture at Xialiao (BL 34) Chengshan 57) was applied tolerant intensity for 30 min before operation all groups. The number additional anesthetic drugs 3 groups,...
Aberrant activation of the PI3K/AKT pathway is considered in many malignant tumors and plays a crucial role mediating malignancy progression, metastasis, chemoresistance. Consequently, development targeted drugs currently an attractive research field for tumor treatment. In this study, twenty-six flavonoid-based amide derivatives were synthesized evaluated their antiproliferation effects against seven cancer cell lines, including MDA-MB-231, MCF-7, HCC1937, A549, HepG2, GTL-16 HeLa. Among...
To examine the factor structure of Sport Concussion Assessment Tool-5 (SCAT5) symptom scale in adolescents on their initial presentation to a concussion clinic within typical recovery period after (ie, <30 days). We hypothesize that SCAT5 symptoms represent various clinically meaningful groups. A secondary purpose was effects sex scale.Retrospective cross-sectional analysis.Tertiary, institutional.Nine hundred eighty-one (45% women) aged between 13 and 18 years.Adolescents completed...
<h3>Objective</h3> To compare regional cortical thicknesses and subcortical gray matter volumes between children aged 9–10 years who play American football vs. non-contact sports. <h3>Design</h3> Secondary analysis of cross-sectional Adolescent Brain Cognitive Development (ABCD) Study data. <h3>Setting</h3> Multi-site study at 21 U.S. institutions. <h3>Participants</h3> 843 (94.0% males) 2,977 sport controls. <h3>Interventions (or Assessment Risk Factors)</h3> Structural magnetic resonance...
PurposeThis study aimed to compare the risk of vagal reflex during microsurgical subinguinal varicocelectomy (MSV) under general anesthesia (GA) with or without additional local anesthetic (LA) spermatic cord block (SCB).MethodA single-center randomized controlled trial was conducted between January 2022 and June 2023.300 patients left-sided grade Ⅲ varicocele were randomly divided into two groups: SCB group (n = 153) control 147)(computer-generated random numbers list). During MSV GA, given...
Recent advances in language models have demonstrated their capability to solve mathematical reasoning problems, achieving near-perfect accuracy on grade-school level math benchmarks like GSM8K. In this paper, we formally study how these problems. We design a series of controlled experiments address several fundamental questions: (1) Can truly develop skills, or do they simply memorize templates? (2) What is the model's hidden (mental) process? (3) Do questions using skills similar different...
Language models have demonstrated remarkable performance in solving reasoning tasks; however, even the strongest still occasionally make mistakes. Recently, there has been active research aimed at improving accuracy, particularly by using pretrained language to "self-correct" their mistakes via multi-round prompting. In this paper, we follow line of work but focus on understanding usefulness incorporating "error-correction" data directly into pretraining stage. This consists erroneous...
We present phi-4, a 14-billion parameter language model developed with training recipe that is centrally focused on data quality. Unlike most models, where pre-training based primarily organic sources such as web content or code, phi-4 strategically incorporates synthetic throughout the process. While previous models in Phi family largely distill capabilities of teacher (specifically GPT-4), substantially surpasses its STEM-focused QA capabilities, giving evidence our data-generation and...