A5009512976- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Blood disorders and treatments
- Mesenchymal stem cell research
- Bacterial Identification and Susceptibility Testing
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunotherapy and Immune Responses
- Autoimmune Neurological Disorders and Treatments
- Cancer-related gene regulation
- Circular RNAs in diseases
- Antibiotics Pharmacokinetics and Efficacy
- Systemic Lupus Erythematosus Research
- Antimicrobial Resistance in Staphylococcus
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Viral Infectious Diseases and Gene Expression in Insects
- Lysosomal Storage Disorders Research
- RNA Research and Splicing
Binzhou University
2023-2025
Binzhou Medical University
2023-2025
Tianjin Medical University
2022-2025
Tianjin First Center Hospital
2022-2025
Nankai University
2023-2025
Human C-type lectin-like molecule 1 (CLL-1) represents a promising therapeutic target for Chimeric antigen receptor T (CAR-T) cells therapy in the treatment of acute myeloid leukemia (AML). In this study, we aimed to evaluate efficacy and safety profile donor-derived CLL-1 CAR-T AML patients who experienced relapsed post-transplantation. 14 relapse following allogeneic HSCT were enrolled our clinical trial. However, 2 withdrew from study due rapid disease progression. 12 participants...
Chimeric antigen receptor (CAR) T-cell therapy plays a critical role in the treatment of B-cell hematologic malignancies. The combination PD-1 inhibitors and CAR-T has shown encouraging results treating patients with relapsed/refractory (R/R) diffuse large lymphoma (DLBCL). However, there are still cases where is ineffective. This study aimed to investigate IL4I1 poor efficacy CD19 combined R/R DLBCL explore potential mechanisms. Transcriptomic metabolomic correlation analyses were performed...
Background: It is difficult for CD19 CAR-T cells to enter solid tumors, which one reason their poor efficacy in lymphoma treatment. The chemokine CXCL13 secreted by stro-mal of the lymph nodes induces homing B and T lymphocytes, express its receptor CXCR5. Preclinical trials have shown that expression CXCR5 on can increase migration tumor microenvironment enhance antitumor function. Methods: We engineered a second receptor, Then, we conducted phase I clinical trial evaluate safety treatment...
Abstract Human antigen R (HuR) is a universally expressed RNA‐binding protein that plays an essential role in governing the fate of mRNA transcripts. Accumulating evidence indicated HuR involved development and functions several cell types. However, its cerebral ischemia/reperfusion injury (CIRI) remains unclear. In this study, we found was significantly upregulated after CIRI. Moreover, silencing could inhibit inflammatory response microglia reduce damage to neurons caused by oxygen–glucose...
<title>Abstract</title> Chimeric antigen receptor (CAR) T-cell therapy plays a critical role in the treatment of B-cell hematologic malignancies. The combination PD-1 inhibitors and CAR-T has shown encouraging results treating patients with relapsed/refractory (R/R) diffuse large lymphoma (DLBCL). However, there are still cases where is ineffective. This study aimed to investigate IL4I1 poor efficacy CD19 combined R/R DLBCL explore potential mechanisms. Transcriptomic metabolomic correlation...
Linezolid is an alternative first-line agent for MRSA pneumonia. This study assessed whether dose adjustments of linezolid against methicillin-resistant Staphylococcus aureus (MRSA) infections were needed based on renal function in populations with different body weight.Monte Carlo simulations conducted to evaluate relation the probability target attainment (PTA) three population groups weight. Area under concentration time curve (AUC)/ minimum inhibitory (MIC) ratio and percentage above MIC...
Abstract Background: TSC22D domain family genes, including TSC22D1-4, have been extensively reported to be involved in tumors. However, their expression profiles and prognostic significance acute myeloid leukemia (AML) remain unknown. Methods: The present study investigated the of genes AML through use multiple online databases, CCLE, EMBL-EBI, HPA, Oncomine,GEPIA2, UALCAN, BloodSpot, GSCALite databases. cBioPortal databases were used explore genetic alteration copy number variation (CNV)...