A5101887560- Oxidative Organic Chemistry Reactions
- Chemical synthesis and alkaloids
- Chemical Synthesis and Analysis
- Alkaloids: synthesis and pharmacology
- Chemical Synthesis and Reactions
- Catalytic C–H Functionalization Methods
- Synthetic Organic Chemistry Methods
- Synthesis of Organic Compounds
- EEG and Brain-Computer Interfaces
- Synthesis and Biological Evaluation
- Synthesis and Catalytic Reactions
- Microbial Natural Products and Biosynthesis
- Synthesis and Reactions of Organic Compounds
- Synthesis and biological activity
- Marine Sponges and Natural Products
- Carbohydrate Chemistry and Synthesis
- ECG Monitoring and Analysis
- Blind Source Separation Techniques
- Phytochemical Studies and Bioactivities
- Porphyrin and Phthalocyanine Chemistry
- Metal complexes synthesis and properties
- Synthesis of heterocyclic compounds
- Multicomponent Synthesis of Heterocycles
- Lysosomal Storage Disorders Research
- Inorganic and Organometallic Chemistry
National University of Defense Technology
2025
XinHua Hospital
1992-2025
Shanghai Jiao Tong University
2023-2025
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2024
Lanzhou University
2018-2024
Northwestern Polytechnical University
2023
University of Pittsburgh Medical Center
2023
First Hospital of Shijiazhuang
2022
Reproductive & Genetic Hospital CITIC-Xiangya
2021
Lanzhou City University
2018-2020
All hyper: Recent advances in the area of chiral hypervalent iodine reagents, notably by groups Kita, Ishihara, and Fujita, enable some oxidative transformations to be conducted an enantioselective manner with asymmetric inductions range 86–95 % ee (see scheme, Mes=mesityl). This contribution highlights representative reactions, reagent/catalyst design, mechanistic aspects reported transformations.
A full account of the oxidative dearomatization para- and ortho-phenolic sulfonamides is provided together with an overview chemistry products their elaboration to building blocks for spirocyclic alkaloids. concise total synthesis putative lepadiformine complements discussion.
An oxidative cyclization of dienic sulfonamides mediated by iodobenzene diacetate in TFA, followed a tandem intramolecular Diels−Alder reaction, achieves desymmetrization "locally symmetrical" dienone with good levels diastereoselectivity and leads to valuable synthetic intermediates for the himandrine alkaloids.
"Hyper" als Erfolgsrezept: Fortschritte insbesondere durch die Gruppen von Kita, Ishihara und Fujita ermöglichen es, einige oxidative Umwandlungen mit chiralen hypervalenten Iodreagentien (siehe Schema; Mes=Mesityl) 86–95 % ee auszuführen. Repräsentative enantioselektive Reaktionen, Beispiele für Reagens- Katalysator-Design sowie mechanistische Aspekte werden vorgestellt.
It has been known that there are microecology disorders during lung cancer development. Theoretically, intratumoral microbiota (ITM) can impact the (LC) survival and treatment efficacy. This study conducted a follow-up investigation of non-small cell (NSCLC) patients without infection to prove whether ITM indeed impacts first-line efficacy survival.We enrolled all diagnosed with NSCLC in our department from 2017 2019, whose tumor samples were available (through surgery or biopsy) sent for...
Mucopolysaccharidosis type II (MPS II) is an X-linked lysosomal storage disorder caused by pathogenic variants in the IDS gene encoding iduronate-2-sulfatase (IDS), which hydrolyzes sulfate groups dermatan and heparan sulfate. The current treatment for MPS includes enzyme replacement therapy hematopoietic stem cell transplantation (HSCT). Both therapies have shown limited penetration through blood-brain barrier. Anecdotal cases been reported with HSCT benefit to treat neurological problems...
Trifluoroacetic acid (TFA) is an effective promoter of the bimolecular Ritter-like oxidative amidation 4-substituted phenols induced by PhI(OAc)2 in MeCN. This suppresses need for fluoroalcohol cosolvents, increases yields, and facilitates isolation/purification procedures.
The sordarin family of compounds, characterized by a unique tetracyclic diterpene core including norbornene system, inhibits protein synthesis in fungi stabilizing the ribosome/EF2 complex. This mode action is contrast to typical antifungals, which target cell membrane. unusual bioactivity makes promising candidate for development new fungicidal agents, and provided motivation extensive research. Three total syntheses (by Kato, Mander Narasaka groups), modifications glycosyl unit, changes...
The di-tert-butylisobutylsilyl (BIBS) protecting group offers new possibilities for synthetic processes because of its steric bulk, robustness derivatives, and other special properties.
Avenues to bi- and tricyclic building blocks for the elaboration of sordaricin its analogues are described. The target molecules were obtained through inter- intramolecular Diels−Alder reactions a number previously unknown cyclopentadienes. Unusual properties 3-cyanoenones 1-cyanocyclopentadienes have been unveiled circumvented.
We describe a synthesis of ketones 3 (X = O-R or CN; Y H alkyl), which are useful building blocks for the preparation analogs potent antifungal agent sordarin, 1. Congeners 1 constructed from should permit detailed SAR investigations terpenoid core natural product.
A Cu(acac)2-catalyzed cyclization reaction of 2-cyanobenzaldehydes with 2-isocyanoacetates has been successfully developed providing an efficient strategy for the synthesis substituted 1-aminoisoquinolines. The proceeds smoothly under mild conditions high efficiency, and might provide alternative 1-aminoisoquinoline containing molecules.
The synthesis of cyanoformamides <italic>via</italic> a CsF-promoted decyanation/oxidation cascade <italic>N</italic>,<italic>N</italic>-disubstituted aminomalononitriles.
Diphenylphosphoryl azide, originally developed by Yamada in 1972, [¹] has shown significant synthetic versatility, [²] being used isocyanate synthesis, especially the Curtius rearrangement, stereospecific conversion of alcohol into [³] as a coupling reagent macrolactamization, [4] allylic amine [5] and aziridination reactions. [6]
Tri-substituted oxazoles, appearing in several anticancer natural products and various other bioactive compounds, have become increasingly visible recent years. Research into the synthesis of such oxazoles has led to development new synthetic methods as well refinements classic their synthesis. In addition, a number research groups pursued fully-functionalized-oxazole-containing products. We review investigations (2004-present) tri-substituted oxazole synthesis, construction complex...
An efficient alkylcyanation of in situ generated arynes by N,N-disubstituted aminomalononitriles is described, enabling the direct synthesis 2-substituted benzonitriles.
The electrocardiogram (ECG) is an important technique for heart disease diagnosis. This paper proposes a novel method ECG beat classification. Several issues exist in the classification, which, if suitably addressed, may lead to development of more robust and efficient recognizers. Some these include feature extraction, choice classification approach optimization. A new non-linear extraction signals based on empirical mode decomposition (EMD), approximate entropy (ApEn) wavelet packet...
Click to increase image sizeClick decrease size Acknowledgements We thank the University of British Columbia, NSERC, CIHR, CFI, BCKDF, and Merck Frosst Canada for support our research program. A portion work presented herein was carried out in Lyon, France, with from Bayer Crop Science, CNRS MRT.