A5058378093- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Esophageal and GI Pathology
- Cancer Diagnosis and Treatment
- Trauma Management and Diagnosis
- Medical Imaging and Pathology Studies
- Cancer Genomics and Diagnostics
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Infectious Diseases and Tuberculosis
- Head and Neck Cancer Studies
- Cancer survivorship and care
- Metastasis and carcinoma case studies
- Otolaryngology and Infectious Diseases
- Viral-associated cancers and disorders
- Cancer Cells and Metastasis
- Parasites and Host Interactions
- Lymphoma Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Spinal Fractures and Fixation Techniques
- Airway Management and Intubation Techniques
- Genetic factors in colorectal cancer
Humboldt-Universität zu Berlin
2024
Charité - Universitätsmedizin Berlin
2024
Freie Universität Berlin
2024
Max Delbrück Center
2024
German Centre for Cardiovascular Research
2024
University of Missouri
2020-2023
University of Missouri Hospital
2023
University of Freiburg
2016-2021
University Medical Center Freiburg
2011-2020
University of Missouri Health System
2020
Circulating tumor DNA (ctDNA) has demonstrated great potential as a noninvasive biomarker to assess minimal residual disease (MRD) and profile genotypes in patients with non‐small‐cell lung cancer (NSCLC). However, little is known about its dynamics during after resection, or for predicting clinical outcomes. Here, we applied targeted‐capture high‐throughput sequencing approach ctDNA at various milestones assessed predictive value early‐stage locally advanced NSCLC. We prospectively enrolled...
IntroductionAdjuvant platinum-based chemotherapy is standard treatment for surgically resected stage II to IIIA NSCLC, but the relapse rate high. The preferentially expressed antigen of melanoma (PRAME) tumor in two-thirds NSCLC and offers an attractive target antigen-specific immunization. A phase I dose escalation study assessed safety immunogenicity a PRAME immunotherapeutic consisting recombinant plus proprietary immunostimulant AS15 patients with (NCT01159964).MethodsPatients...
In Germany, 10,000 cases of spontaneous pneumothorax are treated inpatient every year. The German Society for Thoracic Surgery, in co-operation with the Pulmonology, Radiological Society, and Internal Medicine has developed an S3 guideline on post-interventional moderated by Association Scientific Medical Societies.Based source British (2010) pneumothorax, a literature search was carried out from 2008 onwards, 1960 onwards. Evidence levels according to Oxford Center Evidence-Based (2011)...
Since the introduction of video-assisted lobectomy for non-small-cell lung cancer (NSCLC) into clinical practice, it has been discussed controversially whether mediastinal lymphadenectomy can be performed as effectively an open procedure via thoracotomy. Therefore, we address this issue in a prospective randomized trial conducted our institution. In total, 66 patients with completely staged Stage I NSCLC were included and either group (n = 34) or conventional 32). The thoracoscopic (VATS)...
Targeted next generation sequencing (tNGS) has become part of molecular pathology diagnostics for determining RAS mutation status in colorectal cancer (CRC) patients as predictive tool decision on EGFR-targeted therapy. Here, we investigated profiles case-matched tissue specimens throughout the disease course CRC, to further specify RAS-status dynamics and identify de novo mutations associated with distant metastases. Case-matched formalin-fixed paraffin-embedded (FFPE) resection (n = 70;...
Background Lung cancer is the leading cause of death among malignancies worldwide. Understanding its biology therefore pivotal importance to improve patient's prognosis. In contrast non-neoplastic tissues, cells utilize glucose mainly for production basic cellular modules '(i.e. nucleotides, aminoacids, fatty acids). cancer, Malic enzyme (ME) and ATP-citrate lyase (ACLY) are key enzymes linking aerobic glycolysis acid synthesis may be biological prognostic significance in non-small cell lung...
Abstract Objective Despite the high incidence of lung cancer, little is known about distress in cancer survivors and patients who have survived diagnose for at least 1 year. We investigated prevalence associated factors. Methods performed a multicenter ( n = 6 hospitals) cross‐sectional study. Data were collected using medical records, questionnaires, telephone interview. Distress was measured with Patient Health Questionnaire (PHQ‐4). Odds ratios (OR) factors potentially calculated...
In Germany, 10,000 cases of spontaneous pneumothorax are treated inpatient every year. The German Society for Thoracic Surgery (DGT), in co-operation with the Pulmonology (DGP), Radiological (DRG) and Internal Medicine (DGIM) has developed an S3 guideline on postinterventional moderated by Association Scientific Medical Societies (AWMF).Based source British (BTS2010) pneumothorax, a literature search was carried out from 2008 onwards, post-interventional 1960 onwards. Evidence levels...
Distant metastasis arising from thyroid cancer is rare but has been associated with significantly reduced long-term survival, especially when refractory to radioactive iodine ablation. We provide one of the largest studies worldwide reporting outcome after salvage pulmonary metastasectomy for this entity, aiming identify prognostic factors and analyse surgical indication.We retrospectively analysed medical records 43 patients who had undergone iodine-refractory 1985 2016.The median follow-up...
Intrathoracic fistulae are among the potential sequelae of radiation therapy, empyema and abscess clearance surgical tumour resections. Interdisciplinary plastic-reconstructive flap surgery is a helpful tool for successful treatment intrathoracic fistulae.From February 2006 to April 2016, 13 patients (3 females 10 males) underwent bronchial (n = 5), tracheal 2), oesophageal post-pneumonectomy bronchopleural fistula tracheo-oesophageal 1), gastrobronchial 1) oesophagobronchial fistulae....
Circulating tumor cells (CTC) have been studied extensively in various types and are a well-established prognosticator colorectal cancer (CRC). This is the first study to isolate CTC directly from outflow secondary lung tumors. For this purpose 24 patients with CRC who underwent pulmonary metastasectomy curative intent blood was drawn intraoperatively vein (tumor outflow). In 22 samples CTC-enumeration performed using CellSieve-microfilters immunohistochemical- Giemsa-staining. Additionally...
<b>Hintergrund:</b> Durch geringere Traumata während VATS-Lobektomie erwartet man eine niedrigere Schmerzintensität im Vergleich zur Thorakotomie. Untersuchungen/Metaanalysen zeigen Überlegenheit der VATS-Lobektomie, die bisher nicht in prospektiv-randomisierten Studie gezeigt werden konnte. Ziel unserer Untersuchung war von 2 Gruppen mit Lobektomie wegen Lungenkarzinoms Stadium I, entweder videoassistiert oder via anterolateraler Thorakotomie operiert wurden. <b>Material und Methoden:</b>...
The optimal treatment modalities for patients with stage IIIA N2 non-small cell lung cancer (NSCLC) are still a matter of debate. To provide best outcome and to avoid unnecessary patient selection surgical therapy is crucial. In addition mediastinal downstaging the lymph node ratio (LNR) has been suggested as prognosticator in this group.We retrospectively reviewed clinical histopathologic data 78 NSCLC, who underwent induction two cycles platinum-based chemotherapy intended surgery at our...
Bone morphogenetic proteins (BMPs) are secreted signaling molecules, which play a major role in kidney development and disease. Here, we show the existence of mRNA for BMP-2 BMP receptors BMPR1A, BMPR1B, BMPRII, ACVR1A, ACVR2, ACVR2B differentiated mouse podocytes protein expression BMPR1A human glomerular podocytes. dose dependently increases free cytosolic Ca(2+) concentration proving functional receptor these cells. Recent data indicate that myoblastic cell line breast cancer line, Id-1,...
The species, Paragonimus kellicotti , causes human paragonimiasis in North America. As a foodborne disease, infection with P. occurs after eating raw or undercooked crayfish containing metacercariae. Many risk factors have been described the literature, including young adult age, male, alcohol consumption, outdoor activities involving rivers within Missouri, and ingesting partially cooked crayfish. Here, we report case of 41-year-old male 5-year history cough who presented acute shortness...
Hemoptysis is a worrying symptom for the majority of patients, frequently sign severe disease and can develop into life-threatening situation. Various therapeutic methods medical specialties be involved in management these patients. Guidelines or evidence-based recommendations on this issue are not available. Based our long-term experience considering all established diagnostic means, we propose an algorithm to manage condition.This retrospective analysis cohort from single thoracic surgical...
Surgery is seldom used for palliation in advanced lung cancer and the published data on this issue are very limited. We aimed to assess results of palliative resections identify criteria guide surgical therapy situation.This a retrospective single-institution analysis patients with intended resection. Survival was performed by Kaplan-Meier method, log-rank test Cox proportional hazards regression at statistical significance level P=0.05.Forty-eight received (31 lobectomies, 4 bilobectomies,...
A 24 year old male presented with a history of recurrent bronchopulmonal infections. Chest computed tomography was performed, revealing right central mass. In the following bronchoscopy and ultrasound guided needle aspiration tumour no specific diagnosis could be obtained. Due to location thoracotomy middle lobe resection performed. Histopathological analysis revealed an intrapulmonary, subpleural located Morbus Castleman hyaline-vascular type.Castleman's disease is very rare disorder...
A solitary pulmonary coin lesion can be attributed to a great variety of diseases. One the extremely rare etiologies is human dirofilariasis (HPD). HPD an infection parasite Dirofilaria (D.) and especially type immitis (DI). D. nematode that also known as dog heartworm since it parasites in dog’s heart.
Bipolar "floating" clavicle injuries are infrequent upper-extremity that occur secondary to a high-energy trauma, which can cause dislocation at the sternoclavicular (SC) and acromioclavicular joints. Given rarity of this injury, there is not consensus regarding clinical management. Although anterior dislocations be managed nonoperatively, posterior may pose threat chest-wall structures typically surgically. Here, we present our preferred technique for concomitant management locked SC joint...