A5057978178- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- Genital Health and Disease
- Global Maternal and Child Health
- Pharmaceutical Economics and Policy
- Pharmaceutical studies and practices
- Pharmaceutical Quality and Counterfeiting
- Poverty, Education, and Child Welfare
- COVID-19 and healthcare impacts
- Cervical Cancer and HPV Research
- HIV/AIDS Impact and Responses
- Female Genital Mutilation/Cutting Issues
Clinton Health Access Initiative
2022-2025
Zero to Three
2023
Abstract Introduction Affordable HIV prevention tools are needed in Eastern and Southern Africa (ESA). Several promising long‐acting pre‐exposure prophylaxis (LA‐PrEP) products available or development. However, ESA settings face severe healthcare resource constraints. We aimed to estimate the threshold price at which LA‐PrEP could be cost‐effective three settings. Methods adapted an agent‐based model, EMOD‐HIV, simulate (monthly oral, 2‐ 6‐monthly injectable) rollout South Africa, Zimbabwe...
Abstract Introduction Reductions in HIV acquisition have slowed, and the global community is significantly off track from goals. Oral pre‐exposure prophylaxis (PrEP) alone cannot address diverse needs of millions people at risk acquisition. Long‐acting injectable cabotegravir (CAB‐LA) received United States Food Drug Administration approval for prevention December 2021. When studied, CAB‐LA demonstrated high effectiveness, provides months protection versus daily use, preferred by some users...
Women in sub-Saharan Africa (SSA) experience the world's highest rates of both HIV infection and unintended pregnancy. The Dual Prevention Pill (DPP) is a novel multipurpose prevention technology (MPT) that co-formulates pre-exposure prophylaxis (PrEP) combined hormonal oral contraception into single daily pill. As dual indication product, DPP may be preferred by women facing these overlapping health risks. However, most SSA countries face severe healthcare resource constraints. Research...
Development of and increased access to generic oral medications treat high-burden diseases including human immunodeficiency virus (HIV), tuberculosis, viral hepatitis, malaria have had a major impact on reducing global morbidity mortality. However, adherence these life-saving treatments remains limited for some the most vulnerable underserved populations, whom stigma, control, discretion are critical decisions around care. Current efforts develop long-acting formulations prevent conditions...
The COVID-19 pandemic has overwhelmed health systems with knock on effects diagnosis, treatment, and care. To mitigate the impact, government of Zimbabwe enforced a strict lockdown beginning 30 March 2020 which ran intermittently until early 2021. In this period, Ministry Health Childcare strategically prioritized delivery services leading to partial full suspension considered non-essential, including HIV prevention. As result, Voluntary Medical Male Circumcision (VMMC) were disrupted an 80%...
Abstract Background: The COVID-19 pandemic has overwhelmed health systems with knock on effects diagnosis, treatment and care. To mitigate the impact, government of Zimbabwe enforced a strict lockdown beginning 30 March 2020 which ran intermittently until early 2021. In this period, Ministry Health Childcare strategically prioritized delivery services, leading to partial full suspension services considered non-essential, including HIV prevention. As result, Voluntary Medical Male...