A5078869342- Medication Adherence and Compliance
- Diabetes Treatment and Management
- Takotsubo Cardiomyopathy and Associated Phenomena
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Silymarin and Mushroom Poisoning
- Psychedelics and Drug Studies
- Ultrasound in Clinical Applications
- Pericarditis and Cardiac Tamponade
- Advanced Breast Cancer Therapies
- Radiology practices and education
- Renal and Vascular Pathologies
- Neurosurgical Procedures and Complications
- Cardiovascular Function and Risk Factors
- Phytochemistry and Bioactivity Studies
- Bipolar Disorder and Treatment
- Pharmaceutical studies and practices
- Infant Health and Development
- Diabetes Management and Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Structural Anomalies and Repair
- Radiation Dose and Imaging
- Cardiac Imaging and Diagnostics
- Venomous Animal Envenomation and Studies
Stanford University
2020-2024
Cedars-Sinai Medical Center
2023-2024
Center for Clinical Research (United States)
2023-2024
Ronald Reagan UCLA Medical Center
2021
Palo Alto University
2020
University of California, Los Angeles
2015-2019
Vanderbilt University Medical Center
2019
UCLA Medical Center
2017
Seattle Children's Hospital
2016
University of Washington
2016
Contiguous brain regions associated with a given behavior are increasingly being divided into subregions distinct aspects of that behavior. Using recently developed neuronal hyperpolarizing technologies, we functionally dissect the parafacial region in medulla, which contains key elements central pattern generator for breathing important CO 2 -chemoreception and gating active expiration. By transfecting different populations neighboring neurons allatostatin or HM 4 D G i/o -coupled...
Breathing in mammals is hypothesized to result from the interaction of two distinct oscillators: preBötzinger Complex (preBötC) driving inspiration and lateral parafacial region (pFL) active expiration. To understand interactions between these oscillators, we independently altered their excitability spontaneously breathing vagotomized urethane-anesthetized adult rats. Hyperpolarizing preBötC neurons decreased inspiratory activity initiated expiration, ultimately progressing apnea, i.e.,...
Recently, based on functional differences, we subdivided neurons juxtaposed to the facial nucleus into two distinct populations, parafacial ventral and lateral regions, i.e., pFV pFL. Little is known about composition of these are they homogenous or heterogeneous populations? Here, manipulated their excitability in spontaneously breathing vagotomized urethane anesthetized adult rats further characterize role breathing. In pFL, disinhibition excitation decreased frequency (f) with a...
BackgroundPoint-of-care ultrasonography (POCUS) machines may use deep learning, a subfield of artificial intelligence (AI), to improve image interpretation and acquisition in real time. The impact AI on POCUS learning is unknown.Research QuestionDo AI-enhanced devices equipped with aid cardiac among novices?Study Design MethodsWe conducted single-center investigation from 2021 through 2022. Internal medicine trainees (N = 43) limited experience were randomized receive device (Echonous; n 22)...
Abstract Aim To explore the effect of canagliflozin on kidney and cardiovascular events safety outcomes in individuals with type 2 diabetes chronic disease across geographic regions racial groups. Materials Methods A stratified Cox proportional hazards model was used to assess efficacy by region group. The primary composite outcome a end‐stage (ESKD), doubling serum creatinine (SCr) level, or death from causes. Secondary included: (i) heart failure (HF) hospitalization; (ii) death,...
Abstract Background Point-of-care ultrasound (POCUS) machines may utilize artificial intelligence (AI) to enhance image interpretation and acquisition. This study investigates whether AI-enabled devices improve competency among POCUS novices. Methods We conducted a randomized controlled trial at single academic institution from 2021-2022. Internal medicine trainees (N=43) with limited experience were receive device (Echonous, N=22) or without (Butterfly, N=21) AI-functionality for two weeks...
ABSTRACT Mushroom (amatoxin) poisoning from ingestion is a rare but life-threatening medical emergency characterized by gastrointestinal symptoms before progression to multisystem organ failure in severe cases. Many therapies of amatoxin intoxication have been described, including supportive care, therapies, detoxification strategies, and liver transplant. The evidence supporting these remains limited due the rarity challenge timely diagnosis. We report case Los Angeles causing injury...
Background: Canagliflozin reduces the incidence of kidney and cardiovascular events in people with type 2 diabetes chronic disease (CKD). We assessed effects canagliflozin according to age sex a randomized, placebo-controlled trial.Methods: The CREDENCE study randomized participants albuminuric CKD. on primary outcome (a composite failure, doubling serum creatinine level, or death from causes), secondary outcomes were evaluated by at baseline (<60, 60-69, ≥70 years) using Cox regression...
Background: Diabetes is the most common cause of kidney disease in people requiring renal replacement therapy (RRT). RRT projected to dramatically increase globally, with greatest Asia. CREDENCE showed canagliflozin reduces and cardiovascular (CV) events individuals type 2 diabetes (T2DM) chronic (CKD).Methods: We explored efficacy across geographic regions. A Cox proportional-hazards model was used analyze primary outcome (composite end-stage [dialysis, transplantation, or a sustained eGFR...