A5008250635- Sodium Intake and Health
- Blood Pressure and Hypertension Studies
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Consumer Attitudes and Food Labeling
- Psoriasis: Treatment and Pathogenesis
- Experimental Behavioral Economics Studies
- Health Systems, Economic Evaluations, Quality of Life
- Ethics and Social Impacts of AI
- Economic and Environmental Valuation
- Cardiac Structural Anomalies and Repair
- Hormonal Regulation and Hypertension
- Pharmaceutical studies and practices
- Radiology practices and education
- Statistical Methods in Clinical Trials
- Aortic Disease and Treatment Approaches
- Dermatology and Skin Diseases
- Microscopic Colitis
- Cardiovascular Health and Disease Prevention
- Spondyloarthritis Studies and Treatments
- Renal function and acid-base balance
- Cardiac Valve Diseases and Treatments
- Asthma and respiratory diseases
- Meta-analysis and systematic reviews
- Reliability and Agreement in Measurement
Haverford College
2024
McMaster University
2020-2022
The George Institute for Global Health
2008-2022
UNSW Sydney
2017-2022
University of Ottawa
2018-2019
Merck & Co., Inc., Rahway, NJ, USA (United States)
2019
George Institute for Global Health
2011-2018
Peking University
2013-2018
Services Australia
2018
Mount Sinai Hospital
2018
Salt substitutes with reduced sodium levels and increased potassium have been shown to lower blood pressure, but their effects on cardiovascular safety outcomes are uncertain.
Because T-cell interactions are involved in the pathophysiology of psoriasis, therapy with a modulator may have beneficial effects on psoriasis severity and health-related quality life (HRQL).To assess efficacy safety efalizumab, modulator, patients plaque psoriasis.Phase 3 randomized, double-blind, parallel-group, placebo-controlled trial involving 556 adult stable, moderate to severe conducted at 30 study centers United States Canada between January July 2002.Patients were randomly...
<h3>Objective</h3> To assess the efficacy and safety of a 24-week course efalizumab. <h3>Design</h3> Phase 3, randomized, double-blind, parallel-group, placebo-controlled 12-week study followed by open-label study. <h3>Setting</h3> Outpatient dermatology clinics. <h3>Patients</h3> A total 556 patients with moderate to severe chronic plaque psoriasis who were seeing an outpatient dermatologist included in <h3>Intervention</h3> For weeks 1 12, randomized receive mg/kg efalizumab weekly or...
Abstract Background Chronic diseases are the leading cause of premature death and disability in world with overnutrition a primary diet-related ill health. Excess energy intake, saturated fat, sugar, salt derived from processed foods major disease burden. Our objective is to compare nutritional composition between countries, food companies, over time. Design Surveys will be done each participating country using standardized methodology. Information on nutrient for product sought either...
Background: Front-of-pack nutrition labelling may support healthier packaged food purchases. Australia has adopted a novel Health Star Rating (HSR) system, but the legitimacy of this choice is unknown. Objective: To define effects different formats front-of-pack on healthiness purchases and consumer perceptions. Design: Individuals were assigned at random to access one four labelling—HSR, multiple traffic light labels (MTL), daily intake guides (DIG), recommendations/warnings (WARN)—or...
Background Average sodium intake and stroke mortality in northern China are both among the highest world. An effective, low-cost strategy to reduce this population is urgently needed. Objective We sought determine effects of a community-based reduction program on salt consumption rural China. Design This study was cluster-randomized trial done over 18 months 120 townships (one village from each township) five provinces. Sixty control villages were compared 60 intervention that given access...
Background: SSaSS (Salt Substitute and Stroke Study), a 5-year cluster randomized controlled trial, demonstrated that replacing regular salt with reduced-sodium, added-potassium substitute reduced the risks of stroke, major adverse cardiovascular events, premature death among individuals previous stroke or uncontrolled high blood pressure living in rural China. This study assessed cost-effectiveness profile intervention. Methods: A within-trial economic evaluation was conducted from...
A potassium chloride-containing salt substitute lowers blood pressure levels, but its overall acceptability has been of concern due to potential adverse effects on food taste. In a large-scale, blinded randomised trial evaluating the comparative (65 % sodium chloride, 25 chloride and 10 magnesium sulphate) normal (100 chloride) pressure, we collected data saltiness, flavour food. We performed this at baseline, 1, 6 12 months post-randomisation using 100 mm visual analogue scales for...
<b><i>Background:</i></b> This analysis evaluated the incidence of and risk factors for bevacizumab-related proteinuria assessed any associated clinical sequelae, including renal function changes. <b><i>Methods:</i></b> Patient-level adverse event laboratory data from a pooled safety database were used to characterize alterations in urine protein excretion following interventional therapy ± bevacizumab 17 randomized trials across multiple tumor...
Sacroiliitis, an inflammatory arthropathy associated with ankylosing spondylitis (AS), is found in patients bowel disease (IBD) but may go undiagnosed. The aims of this study were to assess prevalence sacroiliitis IBD and determine association between clinical characteristics sacroiliitis. Inflammatory undergoing abdomino-pelvic computed tomography (CT) for any indication (2006–2015) identified. Using standardized CT scoring, was confirmed. Two blinded readers used a standardised model where...
There is substantial interest in the effects of nutrition labels on consumer food-purchasing behavior. However, conducting randomized controlled trials impact real world presents a significant challenge.The Food Label Trial (FLT) smartphone app was developed to enable fully automated trials, delivering intervention remotely, and collecting individual-level data food purchases for two nutrition-labeling (RCTs) New Zealand Australia.Two versions were developed: one 5-arm trial (Australian)...