A5101779083- Cellular transport and secretion
- Pancreatic function and diabetes
- Advanced Glycation End Products research
- Lipid Membrane Structure and Behavior
- Nuclear Structure and Function
- Cancer Treatment and Pharmacology
- Spectroscopy Techniques in Biomedical and Chemical Research
- Retinal Development and Disorders
- Phytochemistry and Biological Activities
- Transplantation: Methods and Outcomes
- Cancer-related molecular mechanisms research
- Curcumin's Biomedical Applications
- Cancer Immunotherapy and Biomarkers
- Glycosylation and Glycoproteins Research
- RNA Research and Splicing
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Biological and pharmacological studies of plants
- Polysaccharides and Plant Cell Walls
- Autophagy in Disease and Therapy
- Nutrition, Genetics, and Disease
- Effects of Radiation Exposure
- Protein Kinase Regulation and GTPase Signaling
West Anhui University
2025
Hechi University
2024
Fujian Medical University
2016-2024
Union Hospital
2016-2024
Guangdong Medical College
2024
Fujian Provincial Cancer Hospital
2024
Agency for Science, Technology and Research
2009-2014
Singapore Bioimaging Consortium
2009-2014
National University of Singapore
2003
Max Planck Institute for Biophysical Chemistry
2000
Nup1p is a yeast nuclear pore complex protein (nucleoporin) required for import, mRNA export and maintenance of normal architecture. We have used genetic approach to identify other proteins that interact functionally with Nup1p. Here we describe the isolation seventeen mutants confer requirement in background which this normally not essential. Some require wild-type Nup1p, while others are viable combination specific nup1 alleles. Several show nonallelic noncomplementation, suggesting...
Hormones such as glucagon are secreted by Ca(2+)-induced exocytosis of large dense-core vesicles, but the mechanisms involved have only been partially elucidated. Studies pancreatic beta-cells secreting insulin revealed that synaptotagmin-7 alone is not sufficient to mediate Ca(2+)-dependent granule exocytosis, and studies chromaffin cells neuropeptides catecholamines showed synaptotagmin-1 -7 collaborate Ca(2+) sensors for both equally involved. As no other peptide secretion was analysed,...
Heterozygosity for missense mutations (N88S/S90L) in BSCL2 (Berardinelli–Seip congenital lipodystrophy type 2)/Seipin is associated with a broad spectrum of motoneuron diseases. To understand the underlying mechanisms how lead to motor neuropathy, we generated transgenic mice neuron-specific expression wild-type (tgWT) or N88S/S90L mutant (tgMT) human Seipin. Transgenes led WT Seipin brain and spinal cord. TgMT, but not tgWT, exhibited late-onset altered locomotor activities gait...
Purpose: Diabetic keratopathy (DK) is a vision-threatening disease that occurs in people with diabetes. Mounting evidence indicates microRNAs (miRNAs) are indispensable nerve regeneration within DK. Herein, the role of miRNAs associated DK, especially focusing on autophagy and apoptosis regulation, was investigated. Methods: To identify differentially expressed miRNAs, we performed miRNA sequencing trigeminal ganglion (TG) tissues derived from streptozotocin-induced type 1 diabetic mellitus...
Abstract Background Autophagy has recently been shown to be critical for protecting peripheral nerve regeneration. This study explored the impact of miR-542-3p on diabetic corneal regeneration and epithelial healing through regulation autophagy. Methods A type 1 diabetes model was established in male mice streptozotocin administration. Immunofluorescence staining β-Tubulin III sodium fluorescein were performed observe fiber density healing, respectively. Western blotting, immunofluorescence...
Objective: To explore the application and discovery of genotyping, gene sequencing, expression analysis in determination ABO blood group subtypes antigen abnormalities hematological malignancies patients. Methods: From June 2019 to May 2020, three clinical cases were found with forward reverse typing discrepancy or atypical serologic agglutination pattern laboratory transfusion department Hebei Yanda Ludaopei Hospital selected. Sequence-specific primer PCR (PCR-SSP) Sanger sequencing coding...
Abstract Background Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and second leading cause cancer-related deaths worldwide. The heightened mortality associated with HCC largely attributed to its propensity for metastasis, which cannot be achieved without remodeling or loss basement membrane (BM). Despite advancements in targeted therapies immunotherapies, resistance limited efficacy late-stage underscore urgent need better therapeutic options early diagnostic...
To analyze the correlation of