A5001770301- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- Electrospun Nanofibers in Biomedical Applications
- Hair Growth and Disorders
- Advanced X-ray and CT Imaging
- Genomics and Chromatin Dynamics
- Molecular Biology Techniques and Applications
- Insect behavior and control techniques
- Artificial Intelligence in Healthcare and Education
- Neuroscience and Neural Engineering
- Cancer and Skin Lesions
- Radiomics and Machine Learning in Medical Imaging
- Forensic Entomology and Diptera Studies
- Insect and Pesticide Research
Institut National de Criminalistique et de Criminologie
2004-2008
Advanced in vitro models that recapitulate the structural organization and function of human heart are highly needed for accurate disease modeling, more predictable drug screening, safety pharmacology. Conventional 3D Engineered Heart Tissues (EHTs) lack heterotypic cell complexity culture under flow, whereas microfluidic Heart-on-Chip (HoC) general configuration contractile readouts. In this study, an innovative user-friendly HoC model is developed to overcome these limitations, by...
Engineered heart tissues (EHTs) have shown great potential in recapitulating tissue organization, functions, and cell-cell interactions of the human vitro . Currently, multiple EHT platforms are used by both industry academia for different applications, such as drug discovery, disease modelling, fundamental research. The tissues’ contractile force, one main hallmarks function maturation level cardiomyocytes, can be read out from optically tracking movement elastic pillars induced tissues....
The use of Engineered Heart Tissues (EHT) as in vitro model for disease modeling and drug screening has increased, they provide important insight into the genetic mechanisms, cardiac toxicity or responses. Consequently, this highlighted need a standardized, unbiased, robust automatic way to analyze hallmark physiological features EHTs. In study we described validated standalone application EHTs an automatic, robust, unbiased way, using low computational time. “ EHT Analysis ” contains two...
Abstract The high rate of drug withdrawal from the market due to cardiovascular toxicity or lack efficacy, economic burden, and extremely long time before a compound reaches market, have increased relevance human in vitro models like (patient‐derived) pluripotent stem cell (hPSC)‐derived engineered heart tissues (EHTs) for evaluation efficacy compounds at early phase development pipeline. Consequently, EHT contractile properties are highly relevant parameters analysis cardiotoxicity, disease...