A5073282606- Modular Robots and Swarm Intelligence
- Micro and Nano Robotics
- Advanced Materials and Mechanics
- 3D Printing in Biomedical Research
- Advanced Sensor and Energy Harvesting Materials
- Neuroscience and Neural Engineering
- Electrowetting and Microfluidic Technologies
- Surface Modification and Superhydrophobicity
- Microfluidic and Bio-sensing Technologies
- Tissue Engineering and Regenerative Medicine
- Advanced MEMS and NEMS Technologies
- Pickering emulsions and particle stabilization
- Microfluidic and Capillary Electrophoresis Applications
- Supramolecular Self-Assembly in Materials
- Nanomaterials and Printing Technologies
- Adhesion, Friction, and Surface Interactions
- Dielectric materials and actuators
- Innovative Microfluidic and Catalytic Techniques Innovation
- Analytical Chemistry and Sensors
- Interactive and Immersive Displays
- 3D IC and TSV technologies
- Pluripotent Stem Cells Research
- Distributed Control Multi-Agent Systems
- Gold and Silver Nanoparticles Synthesis and Applications
- Opinion Dynamics and Social Influence
Delft University of Technology
2018-2025
Université Libre de Bruxelles
2013-2019
Max Planck Institute for Intelligent Systems
2015-2018
Stuttgart Observatory
2017
Max Planck Society
2015
École Polytechnique Fédérale de Lausanne
2010-2014
KU Leuven
2008-2013
IMEC
2008-2010
University of Pisa
2005-2006
The design and fabrication techniques for microelectromechanical systems (MEMS) nanodevices are progressing rapidly. However, due to material process flow incompatibilities in the of sensors, actuators electronic circuitry, a final packaging step is often necessary integrate all components heterogeneous microsystem on common substrate. Robotic pick-and-place, although accurate reliable at larger scales, serial that downscales unfavorably stiction problems, fragility sheer number components....
other hazard risks of various substances under increasingly stringent regulatory requirements (Marx et al., 2016).Organ-on-Chip (OoC) is regarded as a potentially game-changing technology for these problems (Bahinski 2015) and able to meet the needs different stakeholders (Middelkamp 2016).In spite its promise (Zhang Radisic, 2017), pharma has nevertheless remained cautious invest in this new technology, presently awaiting evidence added cost-benefit value whether it could represent feasible...
We present a wafer-scale fabricated, PDMS-based platform for culturing miniaturized engineered heart tissues (EHTs) which allows highly accurate measurements of the contractile properties these tissues. The design is an anisometrically downscaled version Heart-Dyno system, consisting two elastic micropillars inside elliptic microwell with volume ranging from 3 down to 1μL supports EHT formation. Size downscaling facilitates fabrication and makes it compatible reproducible batch processing;...
Abstract Continuous monitoring of tissue microphysiology is a key enabling feature the organ-on-chip (OoC) approach for in vitro drug screening and disease modeling. Integrated sensing units are particularly convenient microenvironmental monitoring. However, sensitive real-time measurements challenging due to inherently small size OoC devices, characteristics commonly used materials, external hardware setups required support units. Here we propose silicon-polymer hybrid device that...
Dielectric spectroscopy is a label-free, non-contact, real-time, multi-layer sensing technology, and has been used for identification quantification of many biological materials. A combination such features in demand monitoring organ-on-chip systems; however available technologies have yet to address this need. In work, we explore the possibility leveraging inherent dielectric application systems, by investigating three key technological developments using open-ended coaxial probes. Firstly,...
Engineered heart tissues (EHTs) have shown great potential in recapitulating tissue organization, functions, and cell-cell interactions of the human vitro . Currently, multiple EHT platforms are used by both industry academia for different applications, such as drug discovery, disease modelling, fundamental research. The tissues’ contractile force, one main hallmarks function maturation level cardiomyocytes, can be read out from optically tracking movement elastic pillars induced tissues....
Abstract Self‐folding broadly refers to the assembly of 3D structures by bending, curving, and folding without need for manual or mechanized intervention. is scientifically interesting because self‐folded structures, from plant leaves gut villi cerebral gyri, abound in nature. From an engineering perspective, self‐folding sub‐millimeter‐sized addresses major hurdles nano‐ micro‐manufacturing. This review focuses on using surface tension capillary forces derived minimization liquid...
Interaction between dipolar forces, such as permanent magnets, generally leads to the formation of one-dimensional chains and rings. We investigated whether it was possible let dipoles self-assemble into three-dimensional structures by encapsulating them in a shell with specific shape. found that condition for self-assembly crystal is satisfied when energies parallel antiparallel states are equal. Our experiments show most regular formed using cylinders cuboids not spheroids. This simple...
Abstract Ionic polymer metal composites (IPMCs) are a class of materials with rising appeal in biological micro-electromechanical systems (bio-MEMS) due to their unique properties (low voltage output, bio-compatibility, affinity ionic medium). While tailoring and improving actuation capabilities IPMCs is key motivator almost all IPMC manufacturing reports, very little efforts have been dedicated sensing using thinner than 100 µ m. Most reports on utilization rely 180 m-thick Nafion platinum...
Capillarity-driven self-assembly of small chips onto planar target substrates is a promising alternative to robotic pick-and-place assembly.It critically relies on the selective deposition thin fluid films patterned binding sites, which anyway normally non-conformal.We found that addition wetting sidewall, surrounding entire site perimeter, enables conformal coverage arbitrarily shaped sites through dip-coating, significantly improves reproducibility coating process and strongly reduces its...
Capillarity is pivotal to many important technologies, including capillary self-alignment and self-assembly for heterogeneous microsystem integration packaging. Lateral forces ensuing from perturbed fluid menisci were the object of substantial theoretical numerical modeling in recent years. Anyway, those studies so far unsatisfactorily supported by direct experimental inspections. In this paper we present a comprehensive quasi-static study lateral arising constrained cylindrical meniscus...
Organ-on-a-chip (OoC) and microfluidic devices are conventionally produced using microfabrication procedures that require cleanrooms, silicon wafers, photomasks. The prototyping stage often requires multiple iterations of design steps. A simplified process could therefore offer major advantages. Here, we describe a rapid cleanroom-free method maskless photolithography. approach utilizes commercial digital micromirror device (DMD)-based setup 375 nm UV light for backside exposure an...
Within the currently rising trend of heterogeneous microsystem integration and packaging, capillary self-assembly emerges as an innovative technique to enhance, complement eventually replace pick-and-place assembly. Vast literature experimental data support such claim. Still, needs overcome some important limitations in order fully express its potential earn wide industrial recognition. In this paper, we review illustrate what are our opinion challenges ahead for making part-to-substrate...