A5094211700- Synthesis and Biological Evaluation
- Neuroscience of respiration and sleep
- Vestibular and auditory disorders
- Genomics, phytochemicals, and oxidative stress
- Hearing, Cochlea, Tinnitus, Genetics
- Bioactive Compounds and Antitumor Agents
Instituto de Investigación Biosanitaria de Granada
2024-2025
Universidad de Granada
2024-2025
Abstract Tinnitus is the perception of sound without an external source, often associated with changes in auditory pathway and different brain regions. Recent research revealed overload missense variants ANK2 gene individuals severe tinnitus. , encoding ankyrin-B, regulates axon branching inhibits microtubule invasion. Missense mutations may promote excessive axonal formation excitatory synapses. This study aims to generate a patient-derived iPSC model from individual tinnitus differentiate...
Triple-negative breast cancer (TNBC) is characterised by its aggressiveness and resistance to chemotherapy, demanding the development of effective strategies against unique characteristics. Derived from lapacho tree bark, β-lapachone (β-LP) selectively targets cells with elevated levels detoxifying enzyme NQO1. Hydroxytyrosol (HT) a phenolic compound derived olive trees important anticancer properties that include inhibition stem (CSCs) metastatic features in TNBC, as well relevant...