A5018263304- Lipid metabolism and disorders
- Colorectal Cancer Treatments and Studies
- Neonatal Respiratory Health Research
- Personality Disorders and Psychopathology
- Schizophrenia research and treatment
- Peroxisome Proliferator-Activated Receptors
- Neurological and metabolic disorders
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Disease and Adiposity
- Infant Nutrition and Health
- Child Abuse and Trauma
- Tryptophan and brain disorders
- Lung Cancer Treatments and Mutations
- Treatment of Major Depression
- Alcoholism and Thiamine Deficiency
- Hormonal Regulation and Hypertension
- Attention Deficit Hyperactivity Disorder
- Statistical Methods in Clinical Trials
- Mental Health and Psychiatry
- Potassium and Related Disorders
- Cholesterol and Lipid Metabolism
- Congenital Heart Disease Studies
- Mental Health Treatment and Access
- Hepatocellular Carcinoma Treatment and Prognosis
First Hospital of Jiaxing
2024-2025
Eli Lilly (United States)
2020-2024
First People’s Hospital of Zunyi
2024
Zunyi Medical University
2024
Integrated Chinese Medicine (China)
2023
Guangdong General Hospital
2019
Chinese University of Hong Kong
2016-2017
UConn Health
2017
Shatin Hospital
2016
Introduction This study investigates age-related differences in Borderline Personality Disorder (BPD) traits and childhood maltreatment (CM) experiences among adolescents, young adults, older adults within a clinical sample. Methods A cross-sectional design was employed, involving 2029 outpatients aged 15-50 years from the Shanghai Mental Health Center. BPD were assessed using Diagnostic Questionnaire 4th Edition Plus (PDQ-4+), CM evaluated Child Trauma Short Form (CTQ-SF). Participants...
<h3>BACKGROUND AND PURPOSE:</h3> Previous studies by using proton MR spectroscopy found metabolite abnormalities in the cerebral cortex and white matter of patients with type 2 diabetes mellitus. The present study was undertaken to detect differences lenticular nuclei thalamus T2DM. <h3>MATERIALS METHODS:</h3> Twenty subjects T2DM 22 age-matched control underwent single-voxel left right thalami. NAA/Cr Cho/Cr ratios were calculated. Brain lactic acid, fasting blood glucose, glycosylated...
Abstract Aims Patients with severe mental disorders in low-resource settings have limited access to services, resulting overwhelming caregiving burden for families. In extreme cases, this has led the long-term restraining of patients their homes. China underwent a nationwide initiative unlock and provide continued treatment. This study aims quantify household economic families after unlocking treatment, identify factors associated increased due schizophrenia. Methods A total 264 subjects...
Abstract Background/Introduction In a Phase 2 trial, tirzepatide (TZP) dose-dependently reduced HbA1c, body weight and serum triglycerides in moderately obese type diabetes (T2D) patients. Purpose To understand changes fasting lipids with TZP, lipidomics profiling of multiple lipid classes was conducted. Methods Patients (n=314) were randomized to receive weekly subcutaneous dulaglutide, or placebo for 26 weeks. Shotgun lipidomic analysis performed positive electrospray using Sciex Triple...
Abstract Background Investigating the trend of changes in occurrence necrotizing enterocolitis (NEC) preterm infants during 9 years and analyzing risk factors NEC with purpose providing reference for clinical diagnosis treatment NEC. Methods Clinical data Bell’s stage ≥ II from January 2013 to December 2021 Neonatology Department Third Affiliated Hospital Zunyi Medical University was retrospectively analyzed. Trends were analyzed by chi-square test. Subsequently, general (sex, gestational...
Abstract Background In a phase 2 study in participants who have obesity or overweight but not type diabetes (T2D) (n=338), retatrutide (RETA), an agonist of GIP, GLP-1 and glucagon receptors, reduced body weight, glycated hemoglobin, triglycerides (TG), LDL-C VLDL-C. Purpose To better understand the effects RETA on serum lipid profile we analyzed changes apolipoprotein levels distribution size lipoprotein particles. Methods Adult with (BMI ≥30 kg/m2), ≥ 27 kg/m2 &lt; 30 kg/m2)...
Abstract Background/Introduction In the recent phase 2 study (NCT04867785) in patients with type diabetes (T2D), retatrutide, an agonist of glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and glucagon receptors, reduced triglycerides (TG) non-high-density lipoprotein cholesterol (non-HDL-C) up to 35.0% 20.7%, respectively. The angiopoietin-like 3/8 complex (ANGPTL3/8) is most potent circulating inhibitor lipase (LPL), its serum levels have been shown be...
Introduction Borderline Personality Disorder (BPD) traits play a crucial role in the prognosis of psychiatric disorders, as well assessing risks associated with negativity and impulsivity. However, there is lack data regarding distribution characteristics BPD symptoms within clinical populations. Methods A total 3015 participants (1321 males, 1694 females) were consecutively sampled from outpatients at psycho-counseling clinics Shanghai Mental Health Center. assessed using self-reported...
Liver X receptors (LXRs) has become an attractive target for the treatment of many diseases such as hyperlipidemia and diabetes. In this study, SiteID program was used to identify active sites two subtypes LXRs, namely LXRα LXRβ. Molecular docking screen LXRs antagonist from molecular library Huanglian jiedu decoction (HJD), a traditional Chinese medicines which effect on hyperlipidemia, explore binding mode between ligands receptors. The results studies suggest that Baicalin, 5, 2',...
INTRODUCTION: The proposed terminology of “Triple I” was developed to clarify the heterogeneity manifestations associated with chorioamnionitis. This study aims evaluate if those a concordant (both histological and clinical) diagnosis chorioamnionitis are different from that do not meet confirmed criteria. METHODS: Retrospective three-year analysis term patients classified as: 1) clinical (CCA)–via ICD-9 codes, 2) (HCA), 3) concordant. Variables evaluated: age, gravidity, white blood cell...
Background: Vascular endothelial growth factor inhibitors may enhance the efficacy of immunotherapy (PD-1/PD-L1 inhibitors). Patients with EGFR -mutant non-squamous non-small cell lung cancer (EGFRmt nsqNSCLC) who progressed on tyrosine kinase (TKIs) benefited from atezolizumab plus bevacizumab and chemotherapy in IMpower150 (exploratory analysis). Methods: In this randomized, double-blind, phase 3 study (ORIENT-31) conducted at 52 medical centres China, patients EGFRmt nsqNSCLC had TKIs...