A5103814886- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Nerve injury and regeneration
- Spinal Cord Injury Research
- interferon and immune responses
- Mosquito-borne diseases and control
- Bone Metabolism and Diseases
- Insect symbiosis and bacterial influences
- Hydrogels: synthesis, properties, applications
- Immune Response and Inflammation
- Nerve Injury and Rehabilitation
- Mesenchymal stem cell research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Coronary Interventions and Diagnostics
- Immune Cell Function and Interaction
- Viral Infections and Outbreaks Research
- Blood properties and coagulation
- Malaria Research and Control
- Viral Infections and Vectors
- Osteoarthritis Treatment and Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Neurogenesis and neuroplasticity mechanisms
Dalian University of Technology
2025
China Medical University
2025
Sichuan University
2025
Institute of Biophysics
2025
Chinese Academy of Sciences
2025
Soochow University
2024
Qingdao National Laboratory for Marine Science and Technology
2023
Ocean University of China
2023
Kunming Medical University
2019
Nanjing Medical University
2016-2018
Therapeutic strategies for the spinal cord injury (SCI) are limited by current available drug delivery techniques. Here, an in situ gelling system (DDS), composed of a Poloxamer‐407, 188 mixture‐based thermoresponsive hydrogel matrix and, incorporated therapeutic compound (monosialoganglioside, GM1), is developed SCI therapy. A low‐thoracic hemisection rats used as model to evaluate efficiency. The GM1‐incorporating Poloxamer‐407 and polymer solution converted (GM1‐hydrogel) upon...
We have investigated whether fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes defects in the male reproductive system of rat using chronically exposed rats ensure continuous fetus. Five- six-week-old were control diet, or diet containing TCDD, attain an average dose 2.4, 8, and 46 ng TCDD/kg/day for 12 weeks, whereupon mated allowed litter; switched after parturition. Male offsprings develop until kills on PND70 (25 per group) PND120 (all remaining animals). Offspring from...
It has been reported that fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes defects in the male reproductive system of rat. We set out replicate and extend these effects using a robust experimental design. Groups 75 (control vehicle) or 55 (50, 200, 1000 ng TCDD/kg bodyweight) female Wistar(Han) rats were exposed TCDD on gestational day (GD)15, then allowed litter. The high-dose group dams showed no sustained weight loss compared control, but four animals had total litter...
Abstract Triptolide (TP), one of the main active ingredients in Tripterygium wilfordii Hook F, is clinically used to treat immune diseases but known cause liver injury. The aim this study was investigate biomarkers for TP-induced hepatotoxicity mice and determine potential mechanisms its LC/MS-based metabolomics metabolites that were changed accumulation long-chain acylcarnitines serum indicated TP exposure disrupted endogenous peroxisome proliferator-activated receptor α (PPARα) signaling....
We compared the effects of a single acute dose, or chronic fetal exposure, to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on male reproductive system Wistar(Han) rat. Tissue samples were taken from dams gestation day (GD)16 and GD21, offspring postnatal days (PND)70 120. Steady-state concentration TCDD was demonstrated in study: body burdens comparable both studies. Fetal concentrations after demonstrate more potent toxicity versus dosing. In maternal liver, cytochrome P450 (CYP)1A1 CYP1A2...
After traumatic spinal cord injury (SCI), an inhibitory environment that contains chondroitin sulfate proteoglycans (CSPGs) is formed prevents axonal regeneration and growth.As previously reported, local administration of Taxol® at a low concentration has shown promising abilities to promote downregulate molecules after acute SCI. However, the application invasive miniosmotic pump deliver Taxol Cremophor-related toxicity caused by limits Taxol.In this study, sustained release paclitaxel...
Arthrodial cartilage degradation and subchondral bone remodeling comprise the most predominant pathological changes in osteoarthritis (OA). Moreover, accumulating evidence indicates that abnormal expression of osteoprotegerin (OPG), receptor activator nuclear factor kappa-B ligand (RANKL) (RANK) plays a vital role collapse bone. In present study, effects icariin on levels these 3 factors interleukin (IL)-1β-stimulated SW1353 chondrosarcoma cells were investigated. The cultured presence or...
Spinal cord injury (SCI), usually resulting in severe sensory and motor deficits, is a major public health concern. Adipose‑derived stem cells (ADSCs), one type of adult cell, are free from ethical restriction, easily isolated enriched. Therefore, ADSCs may provide feasible cell source for cell‑based therapies treatment SCI. The present study successfully rat (rADSCs) Sprague‑Dawley male rats co‑cultured them with acellular spinal scaffolds (ASCs). Then, hemisection model was built were...
The aryl hydrocarbon receptor (AhR) is required for the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and so AhR CRL:WI CRL:WI(Han) rats was characterized.Western blot showed proteins ~110 ~97 kDa in individual from both strains.The cDNA a rat with ~110-kDa protein revealed sequence that identical to SD rat.However, cloning ~97-kDa point mutation, five variants encoding two C-terminally truncated protein, arising mutation intron/exon junction consequent differential splicing.These...
ABSTRACT Dengue virus (DENV) gains genetic mutations during continuous transmission and evolution, making the more adaptive virulent. The clade of DENV-1 genotype I has expanded become predominant in Asia Pacific areas, but underlying mechanisms are unclear. A combined analysis nonsynonymous domain III envelope protein their biological effects on pathogenesis was evaluated. Phylogenetic analyses found three (V324I, V351L, V380I) protein, which emerged 1970s–1990s stably inherited...